膦酰基羧酸

Description

Phosphonocarboxylic Acid · CAS 4428-95-9 · CH3O5P. UNII 364P9RVW4X. Melting Point: 88.06; Melting Point: 88.06 °C; Solubility: 1.68e+01 g/L.

Identification

CAS Registry Number	4428-95-9
PubChem CID	3415
Molecular formula	CH3O5P
IUPAC name	phosphonoformic acid
UNII (FDA)	364P9RVW4X

Computed Descriptors

Molecular Weight	126.01
XLogP3	-2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	125.97181019
Monoisotopic Mass	125.97181019
Topological Polar Surface Area	94.8
Heavy Atom Count	7
Formal Charge	0

Physical & Chemical Properties

Melting Point	88.06
Melting Point	88.06 °C
Solubility	1.68e+01 g/L
LogP	-2.1
LogP	-2.0

Physical description & handling notes

• Solid
• Complete
• 128.92 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Hexahydrate, mp >250 °C/Foscarnet sodium/
• Each milliliter of foscarnet sodium injection contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH of the solution to 7.4. Foscarnet sodium injection contains no preservatives. /Available in/ 500 or 250 mL bottles.
• Foscavir

GHS Hazard Classification

Reported hazard statements	H341 (100%), H373 (100%)

Documented Uses

• Phosphonoformate is prepared by saponification of the triethyl ester of phosphonoformate with NaOH. Trisodium phosphonoformate hexahydrate is recrystallized from H2O.
• For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
• Foscarnet a simple pyrophosphate molecule which has antiviral activity against many viruses and is used intravenously in therapy of serious cytomegalovirus infections, largely in immunocompromised patients. Foscarnet has been associated with mild-to-moderate serum aminotransferase elevations during intravenous therapy, but not with episodes of clinically apparent liver injury.
• Antiviral Agents; Reverse Transcriptase Inhibitors
• Foscarnet sodium injection is indicated for the treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients. /Included in US product label/
• Foscarnet sodium injection is indicated for the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS). Combination therapy with foscarnet sodium and ganciclovir is indicated for patients who have relapsed after monotherapy with either drug. /Included in US product label/

Synonyms

foscarnet; Phosphonoformic acid; Phosphonoformate; 4428-95-9; Carboxyphosphonic acid; Foscarmet; phosphonocarboxylic acid; phosphonomethanoic acid; 364P9RVW4X; J05AD01; Phosphinecarboxylic acid, dihydroxy-, oxide; DTXSID0048478; CHEBI:127780; RefChem:55232; DTXCID0028452; 112-287-0

Frequently Asked Questions

What are the CAS number and molecular formula of Phosphonocarboxylic Acid?

CAS 4428-95-9; molecular formula CH3O5P; molecular weight — g/mol.

What other names is Phosphonocarboxylic Acid known by?

foscarnet, Phosphonoformic acid, Phosphonoformate, 4428-95-9, Carboxyphosphonic acid, Foscarmet.

Is Phosphonocarboxylic Acid classified as hazardous?

Hazard statements reported: H341, H373.

What are the key physical properties of Phosphonocarboxylic Acid?

Melting Point: 88.06; Melting Point: 88.06 °C; Solubility: 1.68e+01 g/L; LogP: -2.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.