曲酸

Description

Kojic Acid · CAS 501-30-4 · C6H6O4. UNII 6K23F1TT52. Melting Point: 153.5; Melting Point: 153.5 °C; Melting Point: 161 °C.

Identification

CAS Registry Number	501-30-4
PubChem CID	3840
Molecular formula	C6H6O4
IUPAC name	5-hydroxy-2-(hydroxymethyl)pyran-4-one
UNII (FDA)	6K23F1TT52

Computed Descriptors

Molecular Weight	142.11
XLogP3	-0.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	142.02660867
Monoisotopic Mass	142.02660867
Topological Polar Surface Area	66.8
Heavy Atom Count	10
Formal Charge	0

Physical & Chemical Properties

Melting Point	153.5
Melting Point	153.5 °C
Melting Point	161 °C
LogP	-0.64
LogP	log Kow = -0.64
Dissociation Constants	pKa = 7.66 (approx., at 25 °C)

Physical description & handling notes

• Solid
• Prismatic needles from acetone, ethanol+ether or methanol+ethyl acetate
• Crystals
• Prisms, needles from acetone
• Soluble in ethanol, ethyl ether, acetone, DMSO; slightly soluble in benzene
• Soluble in water, acetone; slightly solluble in ether; insoluble in benzene

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Cosmetic ingredients (Kojic Acid) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Antioxidant
GHS notification summary	86.2% (69 / 80)

GHS Hazard Classification

GHS notification summary	86.2% (69 / 80)
Reported hazard statements	H351 (13.8%)

Documented Uses

• Converted to maltol and ethyl maltol, flavor-enhancing additives. Food additive to inhibit tyrosinase.
• Chemical intermediate, metal chelates, ... antifungal and antimicrobial agent
• Kojic acid is widely used as a food additive for preventing enzymatic browning, and in cosmetic preparations as a skin-lightening or bleaching agent.
• Laboratory reagent used as standard chemical for tyrosinase inhibitor assays.
• Antibiotic substance produced in an aerobic process by a variety of microorganisms from a wide-range of carbon sources.
• Fermentation of starches and sugars by certain molds.

Synonyms

kojic acid; 501-30-4; 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; 5-Hydroxy-2-(hydroxymethyl)-4-pyrone; 5-hydroxy-2-(hydroxymethyl)pyran-4-one; 5-Hydroxy-2-hydroxymethyl-4-pyrone; 4H-PYRAN-4-ONE, 5-HYDROXY-2-(HYDROXYMETHYL)-; acido kojico; 2-Hydroxymethyl-5-hydroxy-gamma-pyrone; 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one; DTXSID2040236; CHEBI:43572; 6K23F1TT52; NSC-1942; DTXCID0020236; Beaute

Frequently Asked Questions

What are the CAS number and molecular formula of Kojic Acid?

CAS 501-30-4; molecular formula C6H6O4; molecular weight — g/mol.

What other names is Kojic Acid known by?

kojic acid, 501-30-4, 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, 5-Hydroxy-2-(hydroxymethyl)-4-pyrone, 5-hydroxy-2-(hydroxymethyl)pyran-4-one, 5-Hydroxy-2-hydroxymethyl-4-pyrone.

What is the regulatory status of Kojic Acid?

Documented regulatory listings: CIR / INCI: Cosmetic ingredients (Kojic Acid) -> CIR (Cosmetic Ingredient Review); CIR / INCI: Antioxidant.

Is Kojic Acid classified as hazardous?

86.2% of GHS notifications report no hazard classification (69 of 80).

What are the key physical properties of Kojic Acid?

Melting Point: 153.5; Melting Point: 153.5 °C; Melting Point: 161 °C; LogP: -0.64.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.