视黄醇（CAS 68-26-8）：分子式 C20H30O、分子量 286.5。
| CAS号 | 68-26-8 |
|---|---|
| 分子式 | C20H30O |
| 分子量 | 286.5 |
| 熔点 | 144 to 147 °F (NTP, 1992) |
| 沸点 | 279 to 280 °F at 1e-06 mmHg (NTP, 1992) |
| LogP | 5.68 |
| 应用领域 | Uses: CIR ingredient: Retinol、Essential micronutrient found in animals、[Merck Index] Used as a nutritional supplement for foods、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Vitamin (antixerophthalmic)、MEDICATION、MEDICATION (VET)、For the treatment of vitamin A deficiency. Vitamin A helps regulate the immune system、which helps prevent or fight off infections by making white blood cells that destroy harmful bacteria and viruses.、Use Classification: Cosmetics -> Skin conditioning、Household Products: Information on 27 consumer products that contain Retinol (Vitamin A) in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ... Vitamin A is isolated by liquid-liquid extraction、molecular distillation、and HPLC. Commercial isolation of retinol from natural raw materials starts with fish oils and is conducted in six steps: (1) accumulation of crude vitamin A by the Solexol countercurrent extraction process、(2) short-path distillation of the retinyl esters (200 °C、400 Pa)、(3) ester saponification (KOH、60 -70 °C、30 minutes、N2)、(4) extraction of retinol with ether、(5) short-path distillation of retinol (120 °C、and (6) final purification by crystallization from ethyl formate (-35 °C. With the development of efficient processes for the synthesis of vitamin A on a commercial scale、isolation from natural raw materials has lost importance.、REACTION OF BETA-IONONE AND A PROPARGYL HALIDE、Formulations、Preparations: AQUEOUS SOLN (DISPERSIONS) OF OIL-SOLUBLE VIT ARE PREPARED BY THE USE OF AN EMULSIFYING AGENT SUCH AS POLYSORBATE 80.、There are many types of preparations that contain retinol. These include solutions of pure synthetic retinol and concentrates that contain both retinol and vitamin D in various proportions. Vitamin A capsules contain 3 to 15 mg of retinol (10、000 to 50、000 USP vitamin A units) per capsule: tablets are also available. A water-miscible preparation (15 mg、ml、50、000 USP units、ml) can be given intramuscularly. Tretinoin (all-trans-retinoic acid、RETIN-A) is available for topical use as a solution (0.05%)、a cream (0.05 and 0.1%)、and a gel (0.025 and 0.01%). Isotretinoin (13-cis-retinoic acid、ACCUTANE) is available for oral use as 10、20、and 40 mg capsules.、U.S. Production: (1972) 4.71X10+8 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1985) In the United States、commercial production of synthetic retinol is about 1000 tons、9.08X10+8 g、per year、U.S. Imports: (1972) 8.12X10+8 GRAMS、(1975) 1.30X10+8 GRAMS、(1984) 9.62X10+8 g、Vitamin A and Provitamin A、Synthetic、U.S. Exports: (1972) 1.83X10+8 GRAMS、General Manufacturing Information: Retinol: ACTIVE、Vitamin A: ACTIVE、Retinol is sold almost exclusively in the form of the more stable esters (mainly as retinyl acetate、also as retinyl palmitate and propionate). About 80% of the production is used in animal feed、the remainder in the food and pharmaceutical sectors.、... THE NOMENCLATURE、FOR VIT A UNITAGE、IS IN TERMS OF RETINOL EQUIV、WHICH REPRESENTS 1 UG OF ALL-TRANS-RETINOL、6 UG OF DIETARY BETA-CAROTENE、OR 12 UG OF OTHER PROVITAMIN A CAROTENOIDS. THUS、1 RETINOL EQUIV EQUALS 3.3 IU UNITS OF VIT A ACTIVITY AS SUPPLIED BY RETINOL OR 10 UNITS ... AS SUPPLIED BY BETA-CAROTENE. |
登记用途：Uses: CIR ingredient: Retinol、Essential micronutrient found in animals、[Merck Index] Used as a nutritional supplement for foods、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Vitamin (antixerophthalmic)、MEDICATION、MEDICATION (VET)、For the treatment of vitamin A deficiency. Vitamin A helps regulate the immune system、which helps prevent or fight off infections by making white blood cells that destroy harmful bacteria and viruses.、Use Classification: Cosmetics -> Skin conditioning、Household Products: Information on 27 consumer products that contain Retinol (Vitamin A) in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ... Vitamin A is isolated by liquid-liquid extraction、molecular distillation、and HPLC. Commercial isolation of retinol from natural raw materials starts with fish oils and is conducted in six steps: (1) accumulation of crude vitamin A by the Solexol countercurrent extraction process、(2) short-path distillation of the retinyl esters (200 °C、400 Pa)、(3) ester saponification (KOH、60 -70 °C、30 minutes、N2)、(4) extraction of retinol with ether、(5) short-path distillation of retinol (120 °C、and (6) final purification by crystallization from ethyl formate (-35 °C. With the development of efficient processes for the synthesis of vitamin A on a commercial scale、isolation from natural raw materials has lost importance.、REACTION OF BETA-IONONE AND A PROPARGYL HALIDE、Formulations、Preparations: AQUEOUS SOLN (DISPERSIONS) OF OIL-SOLUBLE VIT ARE PREPARED BY THE USE OF AN EMULSIFYING AGENT SUCH AS POLYSORBATE 80.、There are many types of preparations that contain retinol. These include solutions of pure synthetic retinol and concentrates that contain both retinol and vitamin D in various proportions. Vitamin A capsules contain 3 to 15 mg of retinol (10、000 to 50、000 USP vitamin A units) per capsule: tablets are also available. A water-miscible preparation (15 mg、ml、50、000 USP units、ml) can be given intramuscularly. Tretinoin (all-trans-retinoic acid、RETIN-A) is available for topical use as a solution (0.05%)、a cream (0.05 and 0.1%)、and a gel (0.025 and 0.01%). Isotretinoin (13-cis-retinoic acid、ACCUTANE) is available for oral use as 10、20、and 40 mg capsules.、U.S. Production: (1972) 4.71X10+8 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1985) In the United States、commercial production of synthetic retinol is about 1000 tons、9.08X10+8 g、per year、U.S. Imports: (1972) 8.12X10+8 GRAMS、(1975) 1.30X10+8 GRAMS、(1984) 9.62X10+8 g、Vitamin A and Provitamin A、Synthetic、U.S. Exports: (1972) 1.83X10+8 GRAMS、General Manufacturing Information: Retinol: ACTIVE、Vitamin A: ACTIVE、Retinol is sold almost exclusively in the form of the more stable esters (mainly as retinyl acetate、also as retinyl palmitate and propionate). About 80% of the production is used in animal feed、the remainder in the food and pharmaceutical sectors.、... THE NOMENCLATURE、FOR VIT A UNITAGE、IS IN TERMS OF RETINOL EQUIV、WHICH REPRESENTS 1 UG OF ALL-TRANS-RETINOL、6 UG OF DIETARY BETA-CAROTENE、OR 12 UG OF OTHER PROVITAMIN A CAROTENOIDS. THUS、1 RETINOL EQUIV EQUALS 3.3 IU UNITS OF VIT A ACTIVITY AS SUPPLIED BY RETINOL OR 10 UNITS ... AS SUPPLIED BY BETA-CAROTENE.。
视黄醇 是一种化工化合物，登记 CAS 号为 68-26-8，分子式 C20H30O（分子量 286.5）。
登记 CAS 号：68-26-8
其分子式 C20H30O 由 20 个碳、30 个氢、1 个氧 组成。
别名/同义词：视黄醇 · Vitamin A · Vitamin A oil · Retinol
视黄醇 的 CAS 登记号为 68-26-8。
分子式 C20H30O，分子量 286.5。
别名/同义词：视黄醇、Vitamin A、Vitamin A oil、Retinol。
登记用途：Uses: CIR ingredient: Retinol、Essential micronutrient found in animals、[Merck Index] Used as a nutritional supplement for foods、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Vitamin (antixerophthalmic)、MEDICATION、MEDICATION (VET)、For the treatment of vitamin A deficiency. Vitamin A helps regulate the immune system、which helps prevent or fight off infections by making white blood cells that destroy harmful bacteria and viruses.、Use Classification: Cosmetics -> Skin conditioning、Household Products: Information on 27 consumer products that contain Retinol (Vitamin A) in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ... Vitamin A is isolated by liquid-liquid extraction、molecular distillation、and HPLC. Commercial isolation of retinol from natural raw materials starts with fish oils and is conducted in six steps: (1) accumulation of crude vitamin A by the Solexol countercurrent extraction process、(2) short-path distillation of the retinyl esters (200 °C、400 Pa)、(3) ester saponification (KOH、60 -70 °C、30 minutes、N2)、(4) extraction of retinol with ether、(5) short-path distillation of retinol (120 °C、and (6) final purification by crystallization from ethyl formate (-35 °C. With the development of efficient processes for the synthesis of vitamin A on a commercial scale、isolation from natural raw materials has lost importance.、REACTION OF BETA-IONONE AND A PROPARGYL HALIDE、Formulations、Preparations: AQUEOUS SOLN (DISPERSIONS) OF OIL-SOLUBLE VIT ARE PREPARED BY THE USE OF AN EMULSIFYING AGENT SUCH AS POLYSORBATE 80.、There are many types of preparations that contain retinol. These include solutions of pure synthetic retinol and concentrates that contain both retinol and vitamin D in various proportions. Vitamin A capsules contain 3 to 15 mg of retinol (10、000 to 50、000 USP vitamin A units) per capsule: tablets are also available. A water-miscible preparation (15 mg、ml、50、000 USP units、ml) can be given intramuscularly. Tretinoin (all-trans-retinoic acid、RETIN-A) is available for topical use as a solution (0.05%)、a cream (0.05 and 0.1%)、and a gel (0.025 and 0.01%). Isotretinoin (13-cis-retinoic acid、ACCUTANE) is available for oral use as 10、20、and 40 mg capsules.、U.S. Production: (1972) 4.71X10+8 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1985) In the United States、commercial production of synthetic retinol is about 1000 tons、9.08X10+8 g、per year、U.S. Imports: (1972) 8.12X10+8 GRAMS、(1975) 1.30X10+8 GRAMS、(1984) 9.62X10+8 g、Vitamin A and Provitamin A、Synthetic、U.S. Exports: (1972) 1.83X10+8 GRAMS、General Manufacturing Information: Retinol: ACTIVE、Vitamin A: ACTIVE、Retinol is sold almost exclusively in the form of the more stable esters (mainly as retinyl acetate、also as retinyl palmitate and propionate). About 80% of the production is used in animal feed、the remainder in the food and pharmaceutical sectors.、... THE NOMENCLATURE、FOR VIT A UNITAGE、IS IN TERMS OF RETINOL EQUIV、WHICH REPRESENTS 1 UG OF ALL-TRANS-RETINOL、6 UG OF DIETARY BETA-CAROTENE、OR 12 UG OF OTHER PROVITAMIN A CAROTENOIDS. THUS、1 RETINOL EQUIV EQUALS 3.3 IU UNITS OF VIT A ACTIVITY AS SUPPLIED BY RETINOL OR 10 UNITS ... AS SUPPLIED BY BETA-CAROTENE.。
视黄醇（CAS 68-26-8）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 68-26-8 |
|---|---|
| PubChem CID | 445354 |
| 分子式 | C20H30O |
| IUPAC 名称 | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol |
| UNII（FDA） | G2SH0XKK91 |
| Molecular Weight | 286.5 |
|---|---|
| XLogP3 | 5.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 5 |
| Exact Mass | 286.229665576 |
| Monoisotopic Mass | 286.229665576 |
| Topological Polar Surface Area | 20.2 |
| Heavy Atom Count | 21 |
| Boiling Point | 279 to 280 °F at 1e-06 mmHg (NTP, 1992) |
|---|---|
| Boiling Point | 137-138 °C at 1X10-6 mm Hg |
| Melting Point | 144 to 147 °F (NTP, 1992) |
| Melting Point | 63.5 |
| Melting Point | 62-64 °C |
| Melting Point | 61 - 63 °C |
| Solubility | 0.671 |
| Vapor Pressure | 0.00000008 [mmHg] |
| LogP | 5.68 |
| LogP | log Kow = 5.68 |
retinol; all-trans-Retinol; 68-26-8; Agoncal; trans-retinol; Veroftal; Bentavit A; Homagenets Aoral; Sehkraft A; Testavol S; all-trans-Vitamin A; All-trans retinol; Super A; Axerophtholum; Wachstumsvitamin; Vitaminum A
| 法规与食品接触 | FDA Substance added to food: NUTRIENT SUPPLEMENT Vitamin A VITAMIN A CIR / INCI: Cosmetic ingredients (Retinol) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Skin conditioning |
|---|---|
| GHS 通报统计 | 0.3% (1 / 311) |
| GHS 通报统计 | 0.3% (1 / 311) |
|---|---|
| 已通报的危害声明 | H302 (15.8%), H317 (74.9%), H319 (75.6%), H360 (88.1%), H413 (74.9%) |
维生素A油 · CAS 68-26-8 · C20H30O. UNII G2SH0XKK91. Boiling Point: 279 to 280 °F at 1e-06 mmHg (NTP, 1992); Boiling Point: 137-138 °C at 1X10-6 mm Hg; Melting Point: 144 to 147 °F (NTP, 1992).
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Vitamin A