羟丙甲纤维素

Description

Imiquimod · CAS 99011-02-6 · C14H16N4. UNII P1QW714R7M. Melting Point: 292-294 °C; Melting Point: 292 - 294 °C; Solubility: 2.47e-01 g/L.

Identification

CAS Registry Number	99011-02-6
PubChem CID	57469
Molecular formula	C14H16N4
IUPAC name	1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
UNII (FDA)	P1QW714R7M

Computed Descriptors

Molecular Weight	240.30
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	240.137496527
Monoisotopic Mass	240.137496527
Topological Polar Surface Area	56.7
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	292-294 °C
Melting Point	292 - 294 °C
Solubility	2.47e-01 g/L
LogP	2.7
LogP	2.89

Physical description & handling notes

• Solid
• Crystals from DMF
• Poorly soluble
• When heated to decomposition material emits toxic fumes.
• For topical use, imiquimod is commercially /available/ as a 5% cream. Each gram of the cream contains 50 mg of imiquimod in an off-white, oil-in-water vanishing cream base. Imiquimod topical cream contains methylparaben and propylparaben as preservatives.
• Topical: Cream 5%, Aldara (Graceway).

Regulatory Status

GHS notification summary	2.1% (1 / 47)

GHS Hazard Classification

GHS notification summary	2.1% (1 / 47)
Reported hazard statements	H300 (83%), H315 (93.6%), H319 (91.5%), H335 (87.2%), H413 (50%)

Documented Uses

• Adjuvants, Immunologic; Antineoplastic Agents
• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Consumption (g per capita) in the USA (2002): 0.00241
• Preparation: J. F. Gerster, European Patent Office 145340; idem, United States of America 4689338 (1985, 1987 both to Riker)
• Cellulose, hydrogen 1,2-benzenedicarboxylate, 2-hydroxypropyl methyl ether: ACTIVE

Synonyms

IMIQUIMOD; 99011-02-6; Aldara; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; Zyclara; 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline; R-837; R 837; 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline; S-26308; DTXSID7041047; TMX-101; S 26308; Imiquimodum; S26308

Frequently Asked Questions

What are the CAS number and molecular formula of Imiquimod?

CAS 99011-02-6; molecular formula C14H16N4; molecular weight — g/mol.

What other names is Imiquimod known by?

IMIQUIMOD, 99011-02-6, Aldara, 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, Zyclara, 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine.

Is Imiquimod classified as hazardous?

2.1% of GHS notifications report no hazard classification (1 of 47).

What are the key physical properties of Imiquimod?

Melting Point: 292-294 °C; Melting Point: 292 - 294 °C; Solubility: 2.47e-01 g/L; LogP: 2.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.