根皮素

Description

Phloretin is identified by CAS 60-82-2, molecular formula C15H14O5 and molecular weight 274.08 g/mol. UNII S5J5OE47MK; ChEBI 17276; InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N. Melting Point: 263.5 °C; Solubility: 0.123 mg/mL at 16 °C.

Identification

CAS Registry Number	60-82-2
PubChem CID	4788
Molecular formula	C15H14O5
Molecular weight	274.08 g/mol
IUPAC name	3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
InChIKey	VGEREEWJJVICBM-UHFFFAOYSA-N
UNII (FDA)	S5J5OE47MK
ChEBI ID	CHEBI:17276
FEMA number	4390
JECFA number	2022

Computed Descriptors

Molecular Weight	274.27
XLogP3	2.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	274.08412354
Monoisotopic Mass	274.08412354
Topological Polar Surface Area	98
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	263.5 °C
Solubility	0.123 mg/mL at 16 °C

Physical description & handling notes

• Solid
• Pearl white powder; Sweet aroma
• Slightly soluble in water
• Sparingly soluble (in ethanol)
• 159.02 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 166.83 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

Regulatory & Food Contact	EU Flavoring substances FDA Substance added to food: FLAVORING AGENT OR ADJUVANT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent (TRIHYDROXY-PHENYL)-PROPAN-1-ONE 3-(4-HYDROXY-PHENYL)-1-(2,4,6-TRIHYDROXY-PHENYL)-PROPAN-1-ONE
GHS notification summary	72.4% (118 / 163)

GHS Hazard Classification

GHS notification summary	72.4% (118 / 163)
Reported hazard statements	H315 (27.6%), H319 (27.6%), H335 (27%)

Documented Uses

• Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
• Flavoring Agents -> JECFA Flavorings Index
• Phloretin has known human metabolites that include Phloretin, 2p-hydroxy-glucuronide and Phloretin, 4p-hydroxy-glucuronide.

Synonyms

phloretin; 60-82-2; Dihydronaringenin; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Phloretol; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; DTXSID6022393; S5J5OE47MK; NSC-407292; DTXCID702393; FEMA NO. 4390; CHEBI:17276; 2',4,4',6'-Tetrahydroxydihydrochalcone; 2',4,4',6'-Tetrahydroxy-Dihydrochalcone; RefChem:861869; 200-488-7

Frequently Asked Questions

What are the CAS number and molecular formula of Phloretin?

CAS 60-82-2; molecular formula C15H14O5; molecular weight 274.08 g/mol.

What other names is Phloretin known by?

phloretin, 60-82-2, Dihydronaringenin, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one, Phloretol, 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-.

What is the regulatory status of Phloretin?

Documented regulatory listings: EU Flavoring substances; FDA Substance added to food: FLAVORING AGENT OR ADJUVANT; Flavoring Agents.

Is Phloretin classified as hazardous?

72.4% of GHS notifications report no hazard classification (118 of 163).

What are the key physical properties of Phloretin?

Melting Point: 263.5 °C; Solubility: 0.123 mg/mL at 16 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.