apigenin

Description

apigenin is identified by CAS 520-36-5, molecular formula C15H10O5 and molecular weight 270.05 g/mol. UNII 7V515PI7F6; ChEBI 18388; InChIKey KZNIFHPLKGYRTM-UHFFFAOYSA-N. Melting Point: 345-350 °C; Melting Point: MP: 347.5 °C; Melting Point: 347.5 °C.

Identification

CAS Registry Number	520-36-5
PubChem CID	5280443
Molecular formula	C15H10O5
Molecular weight	270.05 g/mol
IUPAC name	5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
InChIKey	KZNIFHPLKGYRTM-UHFFFAOYSA-N
UNII (FDA)	7V515PI7F6
ChEBI ID	CHEBI:18388

Computed Descriptors

Molecular Weight	270.24
XLogP3	1.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	270.05282342
Monoisotopic Mass	270.05282342
Topological Polar Surface Area	87
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	345-350 °C
Melting Point	MP: 347.5 °C
Melting Point	347.5 °C
LogP	log Kow = 3.02
LogP	3.02

Physical description & handling notes

• Solid
• Yellow needles from aqueous pyridine
• Soluble in ethanol, pyridine, concentrated sulfuric acid; very soluble in dilute alkalies
• Moderately soluble in hot alcohol. Soluble in dilute KOH with intense yellow color
• When heated to decomposition it emits acrid smoke and irritating fumes.
• 154.59 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	24.5% (27 / 110)

GHS Hazard Classification

GHS notification summary	24.5% (27 / 110)
Reported hazard statements	H315 (28.6%), H412 (71.4%), H319 (75.5%), H335 (74.5%)

Documented Uses

• Used as a research chemical, anti-viral agents, anti-tumor, bowel disease and skin conditions. Active ingredient in chamomile, used for indigestion ...
• Has been used to dye chromium mordanted wool yellow. The color is fast to soap.
• Direct dye ... limited application as a component of the hair dye extract chamomile
• Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention.
• The aglucon of apiin and of apigenin-7-glucoside. From apiin by boiling with acids, from apigenin-7-glucoside by enzymatic hydrolysis with emulsion or by boiling with 15% H2SO4
• Four hours after administration of a flavonoid glycoside extract (corresponding to 0.942 mg aglycones) by gavage, the aglycone of apigenin was observed in the lumen and the wall of the stomach, in the lumen of the small intestine and in the lumen and wall of the cecum in Wistar rats. The evidence of glycosides in the stomach wall suggested that the absorption of flavonoids did not require the presence of their aglycones. Under the study conditions, no renal excretion of apigenin was detected ...

Synonyms

apigenin; 520-36-5; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Versulin; Apigenol; 4',5,7-Trihydroxyflavone; Apigenine; Spigenin; C.I. Natural Yellow 1; 5,7,4'-Trihydroxyflavone; 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; Pelargidenon 1449; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

Frequently Asked Questions

What are the CAS number and molecular formula of apigenin?

CAS 520-36-5; molecular formula C15H10O5; molecular weight 270.05 g/mol.

What other names is apigenin known by?

apigenin, 520-36-5, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Versulin, Apigenol, 4',5,7-Trihydroxyflavone.

Is apigenin classified as hazardous?

24.5% of GHS notifications report no hazard classification (27 of 110).

What are the key physical properties of apigenin?

Melting Point: 345-350 °C; Melting Point: MP: 347.5 °C; Melting Point: 347.5 °C; LogP: log Kow = 3.02.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.