保泰松（CAS 50-33-9）：分子式 C19H20N2O2、分子量 308.4。
| CAS号 | 50-33-9 |
|---|---|
| 分子式 | C19H20N2O2 |
| 分子量 | 308.4 |
| 熔点 | 219 to 225 °F (NTP, 1992) |
| LogP | 3.16 |
| 应用领域 | Uses: Analgesic in dogs、cats、horses、cattle、pigs、THERAPEUTIC CATEGORY: Anti-inflammatory、THERAPEUTIC CATEGORY (VETERINARY): Analgesic、anti-inflammatory、MEDICATION、MEDICATION (VET)、Use (kg、approx.) in Germany (2009): >500、Consumption (g per capita、approx.) in Germany (2009): 0.00611、Calculated removal (%): 83.4、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Derived from the condensation of 2-(n-butyl)malonate with 1、2-diphenylhydrazine、Heating diethyl-n-butylmalonate and 1、2-diphenylhydrazine in the presence of sodium ethoxide at 150 °C followed by acidification affords phenylbutazone in good yield. Alternatively、n-butylmalonyl chloride in pyridine and ether at 0 °C is treated with 1、2-diphenylhydrazine to give the desired product.、Reaction of butylmalonyl chloride with hydrazobenzene in ether solution、followed by extraction with sodium carbonate、Formulations、Preparations: Phenylbutazone tablets containing 100 mg and 1000 mg of active ingredient are available for oral administration to dogs and horses、respectively、for treatment of inflammation associated with the musculoskeletal system. Phenylbutazone solution for intravenous injection contains 200 mg、mL of active ingredient and is indicated for the relief of inflammation associated with the musculoskeletal system of the horse.、GRADE: National Formulary、Oral Capsules、100 mg、Phenylbutazone Capsules、Barr、CMC、Interstate、Major、Rugby、Tablets film-coated、Phenylbutazone Tablets、United Research.、U.S. Production: (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1978) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1976) 1.20X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1978) 1.40X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: 3、5-Pyrazolidinedione、4-butyl-1、2-diphenyl-: ACTIVE、A synthetic pyrazolone derivative、Also available as sodium salt |
登记用途：Uses: Analgesic in dogs、cats、horses、cattle、pigs、THERAPEUTIC CATEGORY: Anti-inflammatory、THERAPEUTIC CATEGORY (VETERINARY): Analgesic、anti-inflammatory、MEDICATION、MEDICATION (VET)、Use (kg、approx.) in Germany (2009): >500、Consumption (g per capita、approx.) in Germany (2009): 0.00611、Calculated removal (%): 83.4、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Derived from the condensation of 2-(n-butyl)malonate with 1、2-diphenylhydrazine、Heating diethyl-n-butylmalonate and 1、2-diphenylhydrazine in the presence of sodium ethoxide at 150 °C followed by acidification affords phenylbutazone in good yield. Alternatively、n-butylmalonyl chloride in pyridine and ether at 0 °C is treated with 1、2-diphenylhydrazine to give the desired product.、Reaction of butylmalonyl chloride with hydrazobenzene in ether solution、followed by extraction with sodium carbonate、Formulations、Preparations: Phenylbutazone tablets containing 100 mg and 1000 mg of active ingredient are available for oral administration to dogs and horses、respectively、for treatment of inflammation associated with the musculoskeletal system. Phenylbutazone solution for intravenous injection contains 200 mg、mL of active ingredient and is indicated for the relief of inflammation associated with the musculoskeletal system of the horse.、GRADE: National Formulary、Oral Capsules、100 mg、Phenylbutazone Capsules、Barr、CMC、Interstate、Major、Rugby、Tablets film-coated、Phenylbutazone Tablets、United Research.、U.S. Production: (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1978) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1976) 1.20X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1978) 1.40X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: 3、5-Pyrazolidinedione、4-butyl-1、2-diphenyl-: ACTIVE、A synthetic pyrazolone derivative、Also available as sodium salt。
保泰松 是一种化工化合物，登记 CAS 号为 50-33-9，分子式 C19H20N2O2（分子量 308.4）。
登记 CAS 号：50-33-9
其分子式 C19H20N2O2 由 19 个碳、20 个氢、2 个氮、2 个氧 组成。
别名/同义词：保泰松 · Phenylbutazone
保泰松 的 CAS 登记号为 50-33-9。
分子式 C19H20N2O2，分子量 308.4。
别名/同义词：保泰松、Phenylbutazone。
登记用途：Uses: Analgesic in dogs、cats、horses、cattle、pigs、THERAPEUTIC CATEGORY: Anti-inflammatory、THERAPEUTIC CATEGORY (VETERINARY): Analgesic、anti-inflammatory、MEDICATION、MEDICATION (VET)、Use (kg、approx.) in Germany (2009): >500、Consumption (g per capita、approx.) in Germany (2009): 0.00611、Calculated removal (%): 83.4、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Derived from the condensation of 2-(n-butyl)malonate with 1、2-diphenylhydrazine、Heating diethyl-n-butylmalonate and 1、2-diphenylhydrazine in the presence of sodium ethoxide at 150 °C followed by acidification affords phenylbutazone in good yield. Alternatively、n-butylmalonyl chloride in pyridine and ether at 0 °C is treated with 1、2-diphenylhydrazine to give the desired product.、Reaction of butylmalonyl chloride with hydrazobenzene in ether solution、followed by extraction with sodium carbonate、Formulations、Preparations: Phenylbutazone tablets containing 100 mg and 1000 mg of active ingredient are available for oral administration to dogs and horses、respectively、for treatment of inflammation associated with the musculoskeletal system. Phenylbutazone solution for intravenous injection contains 200 mg、mL of active ingredient and is indicated for the relief of inflammation associated with the musculoskeletal system of the horse.、GRADE: National Formulary、Oral Capsules、100 mg、Phenylbutazone Capsules、Barr、CMC、Interstate、Major、Rugby、Tablets film-coated、Phenylbutazone Tablets、United Research.、U.S. Production: (1976) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1978) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1976) 1.20X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1978) 1.40X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: 3、5-Pyrazolidinedione、4-butyl-1、2-diphenyl-: ACTIVE、A synthetic pyrazolone derivative、Also available as sodium salt。
保泰松（CAS 50-33-9）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 50-33-9 |
|---|---|
| PubChem CID | 4781 |
| 分子式 | C19H20N2O2 |
| IUPAC 名称 | 4-butyl-1,2-diphenylpyrazolidine-3,5-dione |
| UNII（FDA） | GN5P7K3T8S |
| Molecular Weight | 308.4 |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 308.152477885 |
| Monoisotopic Mass | 308.152477885 |
| Topological Polar Surface Area | 40.6 |
| Heavy Atom Count | 23 |
| Melting Point | 219 to 225 °F (NTP, 1992) |
|---|---|
| Melting Point | 105 |
| Melting Point | 105 °C |
| Solubility | 47.5 |
| Solubility | In water, 34 mg/L at 25 °C |
| Solubility | 1.44e-01 g/L |
| LogP | 3.16 |
| LogP | log Kow = 3.16 |
| LogP | 3.7 |
| LogP | 3.3 |
phenylbutazone; 50-33-9; 4-Butyl-1,2-diphenylpyrazolidine-3,5-dione; Butapirazol; Butadion; Butazolidin; Flexazone; Azolid; Butacote; Butazolidine; Ecobutazone; Fenibutazona; Fenilbutazona; Fenylbutazon; Intrabutazone; Artrizin
| 已通报的危害声明 | H301 (94.3%), H312 (67.1%), H315 (72.1%), H317 (40%), H319 (97.1%), H332 (68.6%), H334 (39.3%), H335 (72.9%) |
|---|
保泰松 · CAS 50-33-9 · C19H20N2O2. UNII GN5P7K3T8S. Melting Point: 219 to 225 °F (NTP, 1992); Melting Point: 105; Melting Point: 105 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Phenylbutazone