α-硫辛酸（CAS 1077-28-7）：分子式 C8H14O2S2、分子量 206.3。
| CAS号 | 1077-28-7 |
|---|---|
| 分子式 | C8H14O2S2 |
| 分子量 | 206.3 |
| 熔点 | 60.5 |
| 沸点 | 162.5 |
| LogP | 2.1 |
| 应用领域 | Uses: Nutrition、biochemical research、Thioctic acid、dl-form、THERAPEUTIC CATEGORY: Treatment of liver disease、antidote to poisonous mushrooms (Amanita species).、Use (kg、approx.) in Germany (2009): >7500、Consumption (g per capita、approx.) in Germany (2009): 0.0916、Calculated removal (%): 96.4、For nutritional supplementation、also for treating dietary shortage or imbalance.、Household Products: Information on 1 consumer products that contain Thioctic Acid in the following categories is provided:、• Personal Care、Methods of Manufacturing: Industrial synthesis of thioctic acid is performed in three stages. Monomethyl or monoethyl adipate is converted into the corresponding acid chloride by reaction with thionyl chloride. Treatment with ethylene in the presence of anhydrous aluminum chloride yields 8-chloro-6-ketooctanoate. In the second stage、this ester is reduced to 8-chloro-6-hydroxyoctanoate by using thionyl chloride in pyridine. In the third stage、the chlorine atoms are replaced by sulfur atoms by treatment with sodium disulfide. Hydrolysis of the resulting dithionooctyl ester formed with alcoholic potassium hydroxide gives thioctic acid.、Formulations、Preparations: Oral: Capsules 30 mg Coenzyme Q10、12-5 mg alpha-Lipoic Acid、Coquinone 30 (USANA Health Sciences Inc).、Coquinone 30、Juvenon: acetyl-L-carnitine and alpha lipoic acid、General Manufacturing Information: Helps the body maintain healthy skeletal and cardiac muscle |
登记用途：Uses: Nutrition、biochemical research、Thioctic acid、dl-form、THERAPEUTIC CATEGORY: Treatment of liver disease、antidote to poisonous mushrooms (Amanita species).、Use (kg、approx.) in Germany (2009): >7500、Consumption (g per capita、approx.) in Germany (2009): 0.0916、Calculated removal (%): 96.4、For nutritional supplementation、also for treating dietary shortage or imbalance.、Household Products: Information on 1 consumer products that contain Thioctic Acid in the following categories is provided:、• Personal Care、Methods of Manufacturing: Industrial synthesis of thioctic acid is performed in three stages. Monomethyl or monoethyl adipate is converted into the corresponding acid chloride by reaction with thionyl chloride. Treatment with ethylene in the presence of anhydrous aluminum chloride yields 8-chloro-6-ketooctanoate. In the second stage、this ester is reduced to 8-chloro-6-hydroxyoctanoate by using thionyl chloride in pyridine. In the third stage、the chlorine atoms are replaced by sulfur atoms by treatment with sodium disulfide. Hydrolysis of the resulting dithionooctyl ester formed with alcoholic potassium hydroxide gives thioctic acid.、Formulations、Preparations: Oral: Capsules 30 mg Coenzyme Q10、12-5 mg alpha-Lipoic Acid、Coquinone 30 (USANA Health Sciences Inc).、Coquinone 30、Juvenon: acetyl-L-carnitine and alpha lipoic acid、General Manufacturing Information: Helps the body maintain healthy skeletal and cardiac muscle。
α-硫辛酸 是一种化工化合物，登记 CAS 号为 1077-28-7，分子式 C8H14O2S2（分子量 206.3）。
登记 CAS 号：1077-28-7
其分子式 C8H14O2S2 由 8 个碳、14 个氢、2 个氧、2 个硫 组成。
别名/同义词：α-硫辛酸 · α-Lipoic Acid
α-硫辛酸 的 CAS 登记号为 1077-28-7。
分子式 C8H14O2S2，分子量 206.3。
别名/同义词：α-硫辛酸、α-Lipoic Acid。
登记用途：Uses: Nutrition、biochemical research、Thioctic acid、dl-form、THERAPEUTIC CATEGORY: Treatment of liver disease、antidote to poisonous mushrooms (Amanita species).、Use (kg、approx.) in Germany (2009): >7500、Consumption (g per capita、approx.) in Germany (2009): 0.0916、Calculated removal (%): 96.4、For nutritional supplementation、also for treating dietary shortage or imbalance.、Household Products: Information on 1 consumer products that contain Thioctic Acid in the following categories is provided:、• Personal Care、Methods of Manufacturing: Industrial synthesis of thioctic acid is performed in three stages. Monomethyl or monoethyl adipate is converted into the corresponding acid chloride by reaction with thionyl chloride. Treatment with ethylene in the presence of anhydrous aluminum chloride yields 8-chloro-6-ketooctanoate. In the second stage、this ester is reduced to 8-chloro-6-hydroxyoctanoate by using thionyl chloride in pyridine. In the third stage、the chlorine atoms are replaced by sulfur atoms by treatment with sodium disulfide. Hydrolysis of the resulting dithionooctyl ester formed with alcoholic potassium hydroxide gives thioctic acid.、Formulations、Preparations: Oral: Capsules 30 mg Coenzyme Q10、12-5 mg alpha-Lipoic Acid、Coquinone 30 (USANA Health Sciences Inc).、Coquinone 30、Juvenon: acetyl-L-carnitine and alpha lipoic acid、General Manufacturing Information: Helps the body maintain healthy skeletal and cardiac muscle。
α-硫辛酸（CAS 1077-28-7）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 1077-28-7 |
|---|---|
| PubChem CID | 864 |
| 分子式 | C8H14O2S2 |
| IUPAC 名称 | 5-(dithiolan-3-yl)pentanoic acid |
| UNII（FDA） | 73Y7P0K73Y |
| Molecular Weight | 206.3 |
|---|---|
| XLogP3 | 1.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 206.04352203 |
| Monoisotopic Mass | 206.04352203 |
| Topological Polar Surface Area | 87.9 |
| Heavy Atom Count | 12 |
| Boiling Point | 162.5 |
|---|---|
| Melting Point | 60.5 |
| Melting Point | 47.5-48 °C |
| LogP | 2.1 |
| Dissociation Constants | pKa = 5.10 |
thioctic acid; alpha-Lipoic acid; 6,8-Thioctic acid; Biletan; alpha Lipoic Acid; DL-6,8-Thioctic acid; 5-(dithiolan-3-yl)pentanoic acid; Thioctsan; thioctate; Thiocacid; Thioctan; Tioctic Acid; Acidum thiocticum; A-lipoicum acidum; Lipoic acid, dl-; Lipoic acid, alpha
| GHS 通报统计 | 6.5% (28 / 430) |
|---|
| GHS 通报统计 | 6.5% (28 / 430) |
|---|---|
| 已通报的危害声明 | H302 (93.5%), H315 (48.6%), H317 (46.5%), H319 (47%), H411 (46.5%), H335 (31.7%), H412 (19.5%) |
α-硫辛酸 · CAS 1077-28-7 · C8H14O2S2. UNII 73Y7P0K73Y. Boiling Point: 162.5; Melting Point: 60.5; Melting Point: 47.5-48 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: α-Lipoic Acid