环磷酰胺（CAS 50-18-0）：分子式 C7H15Cl2N2O2P、分子量 261.08。
| CAS号 | 50-18-0 |
|---|---|
| 分子式 | C7H15Cl2N2O2P |
| 分子量 | 261.08 |
| 熔点 | 106 to 113 °F (NTP, 1992) |
| 沸点 | 336 °C |
| LogP | 0.6 |
| 应用领域 | Uses: Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug、[Merck Index] An alkylating agent、[HSDB]、Therap Cat: Antineoplastic、Immunosupressive、Antineoplastic for treatment of leukemia、etc、tested for use in chemical shearing of sheep and as an insect chemosterilant.、MEDICATION、MEDICATION (VET)、Use (kg) in Switzerland (2009): >25、Use (kg、approx.) in Germany (2009): >250、exact) in Germany (2009): 252、Consumption (g per capita) in Switzerland (2009): 0.0032、Consumption (g per capita、approx.) in Germany (2009): 0.0031、exact) in Germany (2009): 0.0031、Excretion rate: 0.2、Calculated removal (%): 22、Cyclophosphamide is indicated for the treatment of malignant lymphomas、multiple myeloma、leukemias、mycosis fungoides (advanced disease)、neuroblastoma (disseminated disease)、adenocarcinoma of the ovary、retinoblastoma、and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.、Methods of Manufacturing: Cyclophosphamide can be prepared by treating N、N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane.、Prepn: H. Arnold et al.、Naturwiss 45、64 (1957)、eidem、Nature 181、931 (1958)、H. Arnold、F. Bourseaux、Angew Chem. 70、539 (1958).、Formulations、Preparations: CYCLOPHOSPHAMIDE IS SUPPLIED AS 25 & 50 MG TABLETS & AS A POWDER (100 TO 2000 MG) IN STERILE VIALS.、Grade: USP、measured as containing 95.0 - 105.0% active ingredient calculated as the monohydrate、5.7 - 6.8% max. water content、0.002% max. heavy metals、and producing an aqueous solution (1 in 100) at pH 3.9 - 7.1.、Available as 25 and 50 mg tablets ... and in vials for injection in amounts of 100、200 or 500 mg measured as containing 90.0 - 110.0% of the stated amount of anhydrous cyclophosphamide.、Consumption Patterns: Total US sales are 600 kg、year (1975)、U.S. Production: Not produced in the US.、U.S. Imports: No data were available on the quantities imported. |
登记用途：Uses: Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug、[Merck Index] An alkylating agent、[HSDB]、Therap Cat: Antineoplastic、Immunosupressive、Antineoplastic for treatment of leukemia、etc、tested for use in chemical shearing of sheep and as an insect chemosterilant.、MEDICATION、MEDICATION (VET)、Use (kg) in Switzerland (2009): >25、Use (kg、approx.) in Germany (2009): >250、exact) in Germany (2009): 252、Consumption (g per capita) in Switzerland (2009): 0.0032、Consumption (g per capita、approx.) in Germany (2009): 0.0031、exact) in Germany (2009): 0.0031、Excretion rate: 0.2、Calculated removal (%): 22、Cyclophosphamide is indicated for the treatment of malignant lymphomas、multiple myeloma、leukemias、mycosis fungoides (advanced disease)、neuroblastoma (disseminated disease)、adenocarcinoma of the ovary、retinoblastoma、and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.、Methods of Manufacturing: Cyclophosphamide can be prepared by treating N、N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane.、Prepn: H. Arnold et al.、Naturwiss 45、64 (1957)、eidem、Nature 181、931 (1958)、H. Arnold、F. Bourseaux、Angew Chem. 70、539 (1958).、Formulations、Preparations: CYCLOPHOSPHAMIDE IS SUPPLIED AS 25 & 50 MG TABLETS & AS A POWDER (100 TO 2000 MG) IN STERILE VIALS.、Grade: USP、measured as containing 95.0 - 105.0% active ingredient calculated as the monohydrate、5.7 - 6.8% max. water content、0.002% max. heavy metals、and producing an aqueous solution (1 in 100) at pH 3.9 - 7.1.、Available as 25 and 50 mg tablets ... and in vials for injection in amounts of 100、200 or 500 mg measured as containing 90.0 - 110.0% of the stated amount of anhydrous cyclophosphamide.、Consumption Patterns: Total US sales are 600 kg、year (1975)、U.S. Production: Not produced in the US.、U.S. Imports: No data were available on the quantities imported.。
环磷酰胺 是一种化工化合物，登记 CAS 号为 50-18-0，分子式 C7H15Cl2N2O2P（分子量 261.08）。
登记 CAS 号：50-18-0
其分子式 C7H15Cl2N2O2P 由 7 个碳、15 个氢、2 个氯、2 个氮、2 个氧、1 个磷 组成。
别名/同义词：环磷酰胺 · cyclophosphamide
环磷酰胺 的 CAS 登记号为 50-18-0。
分子式 C7H15Cl2N2O2P，分子量 261.08。
别名/同义词：环磷酰胺、cyclophosphamide。
登记用途：Uses: Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug、[Merck Index] An alkylating agent、[HSDB]、Therap Cat: Antineoplastic、Immunosupressive、Antineoplastic for treatment of leukemia、etc、tested for use in chemical shearing of sheep and as an insect chemosterilant.、MEDICATION、MEDICATION (VET)、Use (kg) in Switzerland (2009): >25、Use (kg、approx.) in Germany (2009): >250、exact) in Germany (2009): 252、Consumption (g per capita) in Switzerland (2009): 0.0032、Consumption (g per capita、approx.) in Germany (2009): 0.0031、exact) in Germany (2009): 0.0031、Excretion rate: 0.2、Calculated removal (%): 22、Cyclophosphamide is indicated for the treatment of malignant lymphomas、multiple myeloma、leukemias、mycosis fungoides (advanced disease)、neuroblastoma (disseminated disease)、adenocarcinoma of the ovary、retinoblastoma、and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.、Methods of Manufacturing: Cyclophosphamide can be prepared by treating N、N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane.、Prepn: H. Arnold et al.、Naturwiss 45、64 (1957)、eidem、Nature 181、931 (1958)、H. Arnold、F. Bourseaux、Angew Chem. 70、539 (1958).、Formulations、Preparations: CYCLOPHOSPHAMIDE IS SUPPLIED AS 25 & 50 MG TABLETS & AS A POWDER (100 TO 2000 MG) IN STERILE VIALS.、Grade: USP、measured as containing 95.0 - 105.0% active ingredient calculated as the monohydrate、5.7 - 6.8% max. water content、0.002% max. heavy metals、and producing an aqueous solution (1 in 100) at pH 3.9 - 7.1.、Available as 25 and 50 mg tablets ... and in vials for injection in amounts of 100、200 or 500 mg measured as containing 90.0 - 110.0% of the stated amount of anhydrous cyclophosphamide.、Consumption Patterns: Total US sales are 600 kg、year (1975)、U.S. Production: Not produced in the US.、U.S. Imports: No data were available on the quantities imported.。
环磷酰胺（CAS 50-18-0）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 50-18-0 |
|---|---|
| PubChem CID | 2907 |
| 分子式 | C7H15Cl2N2O2P |
| IUPAC 名称 | N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine |
| UNII（FDA） | 6UXW23996M |
| Molecular Weight | 261.08 |
|---|---|
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 260.0248201 |
| Monoisotopic Mass | 260.0248201 |
| Topological Polar Surface Area | 41.6 |
| Heavy Atom Count | 14 |
| Boiling Point | 336 °C |
|---|---|
| Melting Point | 106 to 113 °F (NTP, 1992) |
| Melting Point | 48-49 |
| Melting Point | 49.5-53 °C |
| Melting Point | 41 - 45 °C |
| Melting Point | 49.5 - 53 °C |
| Flash Point | 113 °C c.c. |
| Solubility | 10 to 50 mg/mL at 73 °F (NTP, 1992) |
| Solubility | Soluble. 1-5 g/100 mL at 23 °C |
| Solubility | In water, 40,000 ppm @ 20 °C |
cyclophosphamide; 50-18-0; Cytoxan; Cyclophosphamid; Cyclophosphane; Clafen; Endoxan; Cyclophosphan; Cytophosphan; Procytox; Sendoxan; Cyclophosphamidum; Claphene; Cyclostin; Endoxana; Endoxanal
| 已通报的危害声明 | H301 (63.2%), H302 (35.3%), H318 (36.8%), H340 (95.6%), H350 (98.5%), H360 (94.1%), H372 (36.8%), H362 |
|---|
环磷酰胺 · CAS 50-18-0 · C7H15Cl2N2O2P. UNII 6UXW23996M. Boiling Point: 336 °C; Melting Point: 106 to 113 °F (NTP, 1992); Melting Point: 48-49.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: cyclophosphamide