安非他酮（CAS 34841-39-9）：分子式 C13H18ClNO、分子量 239.74。
| CAS号 | 34841-39-9 |
|---|---|
| 分子式 | C13H18ClNO |
| 分子量 | 239.74 |
| 熔点 | 233-234 °C |
| 沸点 | BP: 52 °C at 0.005 mm Hg |
| LogP | 3.6 |
| 应用领域 | Uses: Antidepressive Agents、Second-Generation、Dopamine Uptake Inhibitors、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 147000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.521、Excretion rate: 0.005、Calculated removal (%): 59.3、For the treatment of depression and as aid to smoking cessation.、Use Classification: Pharmaceuticals、Methods of Manufacturing: m-Chlorobenzonitrile is reacted with ethyl Grignard reagent in ether to produce m-chlorobenzyl ethyl ketone、which is brominated in dichloromethane. The product is reacted with tertiary butyl amine in acetonitrile to yield bupropion base. Treatment of an ethereal solution of the base with dry HCl yields the salt.、Preparation: N. B. Mehta、D. A. Yeowell、German patent 2059618 (1971 to Wellcome Found.)、N. B. Mehta、United States of America patent 3819706 (1974 to Burroughs Wellcome).、Formulations、Preparations: Oral: extended release tablets、174 mg、348 mg、552 mg、Aplenzin (Sanofi-Aventis).、Bupropion hydrobromide、Table: Bupropion Hydrochloride Preparations [Table#6565] |
登记用途：Uses: Antidepressive Agents、Second-Generation、Dopamine Uptake Inhibitors、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 147000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.521、Excretion rate: 0.005、Calculated removal (%): 59.3、For the treatment of depression and as aid to smoking cessation.、Use Classification: Pharmaceuticals、Methods of Manufacturing: m-Chlorobenzonitrile is reacted with ethyl Grignard reagent in ether to produce m-chlorobenzyl ethyl ketone、which is brominated in dichloromethane. The product is reacted with tertiary butyl amine in acetonitrile to yield bupropion base. Treatment of an ethereal solution of the base with dry HCl yields the salt.、Preparation: N. B. Mehta、D. A. Yeowell、German patent 2059618 (1971 to Wellcome Found.)、N. B. Mehta、United States of America patent 3819706 (1974 to Burroughs Wellcome).、Formulations、Preparations: Oral: extended release tablets、174 mg、348 mg、552 mg、Aplenzin (Sanofi-Aventis).、Bupropion hydrobromide、Table: Bupropion Hydrochloride Preparations [Table#6565]。
安非他酮 是一种化工化合物，登记 CAS 号为 34841-39-9，分子式 C13H18ClNO（分子量 239.74）。
登记 CAS 号：34841-39-9
其分子式 C13H18ClNO 由 13 个碳、18 个氢、1 个氯、1 个氮、1 个氧 组成。
别名/同义词：安非他酮 · Bupropion
安非他酮 的 CAS 登记号为 34841-39-9。
分子式 C13H18ClNO，分子量 239.74。
别名/同义词：安非他酮、Bupropion。
登记用途：Uses: Antidepressive Agents、Second-Generation、Dopamine Uptake Inhibitors、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 147000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.521、Excretion rate: 0.005、Calculated removal (%): 59.3、For the treatment of depression and as aid to smoking cessation.、Use Classification: Pharmaceuticals、Methods of Manufacturing: m-Chlorobenzonitrile is reacted with ethyl Grignard reagent in ether to produce m-chlorobenzyl ethyl ketone、which is brominated in dichloromethane. The product is reacted with tertiary butyl amine in acetonitrile to yield bupropion base. Treatment of an ethereal solution of the base with dry HCl yields the salt.、Preparation: N. B. Mehta、D. A. Yeowell、German patent 2059618 (1971 to Wellcome Found.)、N. B. Mehta、United States of America patent 3819706 (1974 to Burroughs Wellcome).、Formulations、Preparations: Oral: extended release tablets、174 mg、348 mg、552 mg、Aplenzin (Sanofi-Aventis).、Bupropion hydrobromide、Table: Bupropion Hydrochloride Preparations [Table#6565]。
安非他酮（CAS 34841-39-9）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 34841-39-9 |
|---|---|
| PubChem CID | 444 |
| 分子式 | C13H18ClNO |
| IUPAC 名称 | 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one |
| UNII（FDA） | 01ZG3TPX31 |
| Molecular Weight | 239.74 |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | 239.1076919 |
| Monoisotopic Mass | 239.1076919 |
| Topological Polar Surface Area | 29.1 |
| Heavy Atom Count | 16 |
| Boiling Point | BP: 52 °C at 0.005 mm Hg |
|---|---|
| Melting Point | 233-234 °C |
| Solubility | 312 |
| LogP | 3.6 |
| LogP | 3.0 |
| Dissociation Constants | 8.35 |
| Dissociation Constants | 8.2 |
bupropion; Amfebutamone; 34911-55-2; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; Amfebutamon; amfebutamonum; Amfebutamona; (+-)-Bupropion; Elontril; Bupropion slow release; bupropione; Bupropion extended release; alpha-(tert-butylamino)-m-chloropropiophenone; 01ZG3TPX31; NSC-758686; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
| 已通报的危害声明 | H302 |
|---|
安非他酮 · CAS 34841-39-9 · C13H18ClNO. UNII 01ZG3TPX31. Boiling Point: BP: 52 °C at 0.005 mm Hg; Melting Point: 233-234 °C; Solubility: 312.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Bupropion