华法林（CAS 951658-59-6）：分子式 C19H16O4、分子量 308.3。
| CAS号 | 951658-59-6 |
|---|---|
| 分子式 | C19H16O4 |
| 分子量 | 308.3 |
| 熔点 | 322 °F (EPA, 1998) |
| 沸点 | 356 °C @760 [mm Hg] |
| LogP | 2.7 |
| 应用领域 | Uses: Warfarin and its sodium salt are registered for use in controlling rats and mice、has been used successfully against common vampire bats、a blood anticoagulant、its sodium salt is used medically to treat people with blood hypercoagulation problems、[HSDB] Warfarin competes with vitamin K and inhibits hepatic synthesis of clotting factors to increase the prothrombin time. Typical therapeutic doses are 2 to 10 mg、day. [ACGIH]、Farming (Pesticides) [Category: Industry]、For warfarin (USEPA、OPP Pesticide Code: 086002) ACTIVE products with label matches.、SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Warfarin and its sodium salt are registered for use in controlling commensal rodents (rats and mice) in and around homes、animal and agricultural premises、and commercial and industrial sites.、Warfarin is a blood anticoagulant、its sodium salt is used medically to treat people with blood hypercoagulation problems.、... Warfarin has been used successfully against common vampire bats.、For more Uses (Complete) data for WARFARIN (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >25、Use (kg) in USA (2002): 2320、Consumption (g per capita、approx.) in Germany (2009): 0.000305、Consumption (g per capita) in the USA (2002): 0.00822、Calculated removal (%): 50.7、Warfarin is an anticoagulant drug and rodenticide derived from coumarin. As a drug it is used for the treatment of retinal vascular occlusion、pulmonary embolism、cardiomyopathy、atrial fibrillation and flutter、cerebral embolism、transient cerebral ischaemia、arterial embolism and thrombosis. (A308)、Use Classification: RODENTICIDES、Methods of Manufacturing: By addition of 4-hydroxycoumarin to benzalacetone under the catalytic influence of a mildly basic substance such as ammonia or piperidine. The reaction is a typical Michael condensation. Conversion to the sodium salt is effected by reacting purified warfarin with an equimolar portion of dilute NaOH solution at room temperature.、Prepared by the Michael condensation of benzylidene acetone with 4-hydroxycourmarin.、Preparation: M. A. Stahmann et al.、United States of America patent 2427578 (1947 to Wisconsin Alumni Research Foundation)、Formulations、Preparations: Formulation types、incl、bait、&、concentrate. Mixed formulations、(warfarin +) pindone、calciferol、sulfaquinoxaline.、Rat baits are usually made up by mixing 1 part of commercial prepn containing 0.5 or 0.1% warfarin with 20 parts of oatmeal or other suitable diluent.、Warfarin Plus rodenticide - Discontinued by HACCO、Inc.、Warfarin Q rodenticide (warfarin) - Discontinued by Bell Labs、Warfotox rodenticide (warfarin) - Discontinued 2008 by Aimco Pesticides Ltd.、Table: Warfarin Sodium Preparations [Table#3584]、For more Formulations、Preparations (Complete) data for WARFARIN (38 total)、U.S. Production: (1985) Data not given、General Manufacturing Information: 2H-1-Benzopyran-2-one、4-hydroxy-3-(3-oxo-1-phenylbutyl)-: ACTIVE、The WHO Recommended Classification of Pesticides by Hazard identifies warfarin (technical grade) as Class IB: highly hazardous、Main Use: rodenticide.、Warfarin、a potent anticoagulant、was first isolated from spoiled clover hay and identified as the agent responsible for the hemorrhagic symptoms associated with the death of livestock in the 1930s.、Warfarin is a racemic mixture whether it is used as rodenticide or as a drug.、Marketed as the racemate、the S(-)-form is the more potent isomer. |
登记用途：Uses: Warfarin and its sodium salt are registered for use in controlling rats and mice、has been used successfully against common vampire bats、a blood anticoagulant、its sodium salt is used medically to treat people with blood hypercoagulation problems、[HSDB] Warfarin competes with vitamin K and inhibits hepatic synthesis of clotting factors to increase the prothrombin time. Typical therapeutic doses are 2 to 10 mg、day. [ACGIH]、Farming (Pesticides) [Category: Industry]、For warfarin (USEPA、OPP Pesticide Code: 086002) ACTIVE products with label matches.、SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Warfarin and its sodium salt are registered for use in controlling commensal rodents (rats and mice) in and around homes、animal and agricultural premises、and commercial and industrial sites.、Warfarin is a blood anticoagulant、its sodium salt is used medically to treat people with blood hypercoagulation problems.、... Warfarin has been used successfully against common vampire bats.、For more Uses (Complete) data for WARFARIN (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >25、Use (kg) in USA (2002): 2320、Consumption (g per capita、approx.) in Germany (2009): 0.000305、Consumption (g per capita) in the USA (2002): 0.00822、Calculated removal (%): 50.7、Warfarin is an anticoagulant drug and rodenticide derived from coumarin. As a drug it is used for the treatment of retinal vascular occlusion、pulmonary embolism、cardiomyopathy、atrial fibrillation and flutter、cerebral embolism、transient cerebral ischaemia、arterial embolism and thrombosis. (A308)、Use Classification: RODENTICIDES、Methods of Manufacturing: By addition of 4-hydroxycoumarin to benzalacetone under the catalytic influence of a mildly basic substance such as ammonia or piperidine. The reaction is a typical Michael condensation. Conversion to the sodium salt is effected by reacting purified warfarin with an equimolar portion of dilute NaOH solution at room temperature.、Prepared by the Michael condensation of benzylidene acetone with 4-hydroxycourmarin.、Preparation: M. A. Stahmann et al.、United States of America patent 2427578 (1947 to Wisconsin Alumni Research Foundation)、Formulations、Preparations: Formulation types、incl、bait、&、concentrate. Mixed formulations、(warfarin +) pindone、calciferol、sulfaquinoxaline.、Rat baits are usually made up by mixing 1 part of commercial prepn containing 0.5 or 0.1% warfarin with 20 parts of oatmeal or other suitable diluent.、Warfarin Plus rodenticide - Discontinued by HACCO、Inc.、Warfarin Q rodenticide (warfarin) - Discontinued by Bell Labs、Warfotox rodenticide (warfarin) - Discontinued 2008 by Aimco Pesticides Ltd.、Table: Warfarin Sodium Preparations [Table#3584]、For more Formulations、Preparations (Complete) data for WARFARIN (38 total)、U.S. Production: (1985) Data not given、General Manufacturing Information: 2H-1-Benzopyran-2-one、4-hydroxy-3-(3-oxo-1-phenylbutyl)-: ACTIVE、The WHO Recommended Classification of Pesticides by Hazard identifies warfarin (technical grade) as Class IB: highly hazardous、Main Use: rodenticide.、Warfarin、a potent anticoagulant、was first isolated from spoiled clover hay and identified as the agent responsible for the hemorrhagic symptoms associated with the death of livestock in the 1930s.、Warfarin is a racemic mixture whether it is used as rodenticide or as a drug.、Marketed as the racemate、the S(-)-form is the more potent isomer.。
华法林 是一种化工化合物，登记 CAS 号为 951658-59-6，分子式 C19H16O4（分子量 308.3）。
登记 CAS 号：951658-59-6
其分子式 C19H16O4 由 19 个碳、16 个氢、4 个氧 组成。
别名/同义词：华法林 · Warfarin
华法林 的 CAS 登记号为 951658-59-6。
分子式 C19H16O4，分子量 308.3。
别名/同义词：华法林、Warfarin。
登记用途：Uses: Warfarin and its sodium salt are registered for use in controlling rats and mice、has been used successfully against common vampire bats、a blood anticoagulant、its sodium salt is used medically to treat people with blood hypercoagulation problems、[HSDB] Warfarin competes with vitamin K and inhibits hepatic synthesis of clotting factors to increase the prothrombin time. Typical therapeutic doses are 2 to 10 mg、day. [ACGIH]、Farming (Pesticides) [Category: Industry]、For warfarin (USEPA、OPP Pesticide Code: 086002) ACTIVE products with label matches.、SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Warfarin and its sodium salt are registered for use in controlling commensal rodents (rats and mice) in and around homes、animal and agricultural premises、and commercial and industrial sites.、Warfarin is a blood anticoagulant、its sodium salt is used medically to treat people with blood hypercoagulation problems.、... Warfarin has been used successfully against common vampire bats.、For more Uses (Complete) data for WARFARIN (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >25、Use (kg) in USA (2002): 2320、Consumption (g per capita、approx.) in Germany (2009): 0.000305、Consumption (g per capita) in the USA (2002): 0.00822、Calculated removal (%): 50.7、Warfarin is an anticoagulant drug and rodenticide derived from coumarin. As a drug it is used for the treatment of retinal vascular occlusion、pulmonary embolism、cardiomyopathy、atrial fibrillation and flutter、cerebral embolism、transient cerebral ischaemia、arterial embolism and thrombosis. (A308)、Use Classification: RODENTICIDES、Methods of Manufacturing: By addition of 4-hydroxycoumarin to benzalacetone under the catalytic influence of a mildly basic substance such as ammonia or piperidine. The reaction is a typical Michael condensation. Conversion to the sodium salt is effected by reacting purified warfarin with an equimolar portion of dilute NaOH solution at room temperature.、Prepared by the Michael condensation of benzylidene acetone with 4-hydroxycourmarin.、Preparation: M. A. Stahmann et al.、United States of America patent 2427578 (1947 to Wisconsin Alumni Research Foundation)、Formulations、Preparations: Formulation types、incl、bait、&、concentrate. Mixed formulations、(warfarin +) pindone、calciferol、sulfaquinoxaline.、Rat baits are usually made up by mixing 1 part of commercial prepn containing 0.5 or 0.1% warfarin with 20 parts of oatmeal or other suitable diluent.、Warfarin Plus rodenticide - Discontinued by HACCO、Inc.、Warfarin Q rodenticide (warfarin) - Discontinued by Bell Labs、Warfotox rodenticide (warfarin) - Discontinued 2008 by Aimco Pesticides Ltd.、Table: Warfarin Sodium Preparations [Table#3584]、For more Formulations、Preparations (Complete) data for WARFARIN (38 total)、U.S. Production: (1985) Data not given、General Manufacturing Information: 2H-1-Benzopyran-2-one、4-hydroxy-3-(3-oxo-1-phenylbutyl)-: ACTIVE、The WHO Recommended Classification of Pesticides by Hazard identifies warfarin (technical grade) as Class IB: highly hazardous、Main Use: rodenticide.、Warfarin、a potent anticoagulant、was first isolated from spoiled clover hay and identified as the agent responsible for the hemorrhagic symptoms associated with the death of livestock in the 1930s.、Warfarin is a racemic mixture whether it is used as rodenticide or as a drug.、Marketed as the racemate、the S(-)-form is the more potent isomer.。
华法林（CAS 951658-59-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 951658-59-6 |
|---|---|
| PubChem CID | 54678486 |
| Molecular formula | C19H16O4 |
| IUPAC name | 4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one |
| UNII (FDA) | 5Q7ZVV76EI |
| Molecular Weight | 308.3 |
|---|---|
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 308.10485899 |
| Monoisotopic Mass | 308.10485899 |
| Topological Polar Surface Area | 63.6 |
| Heavy Atom Count | 23 |
| Boiling Point | 356 °C @760 [mm Hg] |
|---|---|
| Melting Point | 322 °F (EPA, 1998) |
| Melting Point | 161 |
| Melting Point | 161 °C |
| Melting Point | 322 °F |
| Solubility | 0.002 % (NIOSH, 2024) |
| Solubility | 17 |
| Solubility | In water, 17 mg/L at 20 °C |
| Solubility | 0.017 mg/mL at 20 °C |
| Solubility | 0.002% |
warfarin; 81-81-2; Coumafene; Zoocoumarin; Coumafen; Brumolin; Coumefene; Dethmor; Kumader; Warfarine; Kumadu; Vampirinip II; Coumarins; Kypfarin; Rodafarin; Solfarin
| Reported hazard statements | H300, H310, H330, H372, H411, H312 (18.9%), H319 (17.4%), H360 (98%) |
|---|
H300: Fatal if swallowed [Danger Acute toxicity, oral]
H310: Fatal in contact with skin [Danger Acute toxicity, dermal]
Warfarin · CAS 951658-59-6 · C19H16O4. UNII 5Q7ZVV76EI. Boiling Point: 356 °C @760 [mm Hg]; Melting Point: 322 °F (EPA, 1998); Melting Point: 161.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Warfarin