沃拉西尼

沃拉西尼（CAS 1644545-52-7）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的记载用途

Vorasidenib is indicated for the treatment of adult and pediatric patients 12 years and older with Grade 2 astrocytoma or oligodendroglioma with a susceptible isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2) mutation following surgery including biopsy, sub-total resection, or gross total resection.Vorasidenib is an orally available, small molecule inhibitor of mutatedisocitrate dehydrogenase-1 and -2 (IDH1 and IDH2) that is used in thetreatment of brain tumors (astrocytoma and oligodendroglioma) with IDHmutations. Vorasidenib is associated with a high rate of serumaminotransferase elevations during therapy and has been linked to rareinstances of clinically apparent liver injury, including an autoimmune-likehepatitis and acute liver failure.

同义词与商品名

Vorasidenib; 1644545-52-7; AG-881; Voranigo; AG881; 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine; 789Q85GA8P; 1,3,5-Triazine-2,4-diamine, 6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R)-2,2,2-trifluoro-1-methylethyl]-; 1,3,5-Triazine-2,4-diamine, 6-(6-chloro-2-pyridinyl)-N2,N4-bis((1R)-2,2,2-trifluoro-1-methylethyl)-; vorasidenibum; 6-(6-chloropyridin-2-yl)-2-N,4-N-bis((2R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine; AG 881; RefChem:902054; Vorasidenib [INN]; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine; Vorasidenib [USAN]

公开数据库对它的描述

Vorasidenib · CAS 1644545-52-7 · C14H13ClF6N6. UNII 789Q85GA8P.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。