Vitamin C（CAS 50-81-7）：分子式 C6H8O6、分子量 176.03 g/mol。
| CAS号 | 50-81-7 |
|---|---|
| 分子式 | C6H8O6 |
| 分子量 | 176.03 g/mol |
| 熔点 | 191 |
| LogP | -1.85 |
| 应用领域 | Uses: CIR ingredient: L-Ascorbic Acid、CIR ingredient: Ascorbic Acid、An antioxidant essential in the human diet、Used as an antioxidant for foods and therapeutic vitamin、[Merck Index] Used as an antioxidant and pH adjustor in cosmetics (over 75% in hair dyes and colors)、for abscission of citrus fruit in harvesting、as a reducing agent in analytical chemistry、skin protectant、and UV sunscreen、[HSDB] Used in chemical synthesis、[IUCLID] Used as flavoring agent、antimicrobial agent、antioxidant、dough strengthener、nutritional supplement、pH control agent、sequestrant、and stabilizer or thickener for foods、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Dietary supplement、As antimicrobial and antioxidant in foodstuffs、Nutrition、color fixing、flavoring and preservative in meats and other foods、oxidant in bread dough、abscission of citrus fruit in harvesting、reducing agent in analytical chemistry、The iron、calcium、and sodium salts are available for biochemical research.、For more Uses (Complete) data for L-Ascorbic Acid (12 total)、please visit the HSDB record page.、Use Classification: EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives、Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern、Fragrance Ingredients、Food Additives -> ANTIOXIDANT -> JECFA Functional Classes、Cosmetics -> Buffering、Antioxidant、Industry Uses: Intermediate、Not Known or Reasonably Ascertainable、Consumer Uses: Not Known or Reasonably Ascertainable、Anti-stain agent、Other、Household Products: Information on 30 consumer products that contain Ascorbic Acid (Vitamin C) in the following categories is provided:、• Personal Care、• Pet Care、Information on 252 consumer products that contain Ascorbic acid in the following categories is provided:、Methods of Manufacturing: The classical Reichstein - Grussner synthesis starts with reduction of D-glucose to D-sorbitol by hydrogenation over a nickel catalyst. The microbiological oxidation of D-sorbitol to L-sorbose is carried out with Acetobacter xylinum. On treatment of L-sorbose with acetone at low temperature in the presence of sulfuric acid、2、3:4、6-di-O-isopropylidene-alpha-L-sorbofuranose is formed. The di-O-isopropylidenyl protection of the hydroxyl-groups at C-2、C-3 and C-4、C-6 allows high-yield oxidation to di-O-isopropylidene-2-ketogulonic acid、without over-oxidation or other side reactions. The oxidation is carried out with potassium permanganate in alkaline solution. Treatment of、di-O-isopropylidene-2-ketogulonic acid、with hot water affords 2-keto-L-gulonic acid、which is converted to L-ascorbic acid by heating in water at 100 °C (20% yield) or by esterification and treatment with sodium methoxide in methanol followed by acidification with hydrogen chloride、yielding ca. 70% of、L-ascorbic acid、. The overall yield of ascorbic acid from D-glucose is 15-18%.、Impurities: Oxalic acid < 0.2%、Heavy metals (as Pb): < 10 mg、kg、Formulations、Preparations: Ascorbic Acid (various manufacturers) Injection: 500 mg、mL、In 50 mL vials. Ascor L 500 (McGuff) Injection: 500 mg、0.025% EDTA. Preservative-free. In 50 mL.、Ascorbic Acid (as Ascorbic Acid or Sodium Ascorbate): Bulk: Powder. Oral: Capsules、extended-release 250 mg 500 mg. Lozenges 60 mg、Solution 25 mg、drop、100 mg、500 mg、5 mL. Tablets: 100 mg、250 mg、1 g. Tablets、chewable、1 g. Tablets、extended-release: 500 mg、1 g. 1.5 g. (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name.)、Ascorbic acid and sodium ascorbate are also commercially available in combination with other vitamins、minerals、amino acids、analgesic-antipyretics、anticholinergics、antihistamines、anti-inflammatory agents、cerebral stimulants、cough suppressants、enzymes、expectorants、hormones、infant formulas、keratolytic agents、laxatives、protein supplements、sedatives、and sympathomimetics. For iv infusion、ascorbic acid or sodium ascorbate is also commercially available in combination with other vitamins in caloric and electrolyte solutions.、Grades: USP、FCC[Lewis RJ Sr、Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007)、Consumption Patterns: CHEMICAL PROFILE: Ascorbic Acid. US End-use Pattern for Ascorbic Acid in 1986.、Table: US End-use pattern for ascorbic acid in 1986. [Table#2222]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1989.、Table: US End-use pattern for ascorbic acid in 1989 [Table#2223]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1992.、Table: US End-use pattern for ascorbic acid in 1992 [Table#2224]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1995.、Table: US End-use pattern for ascorbic acid in 1995 [Table#2225]、For more Consumption Patterns (Complete) data for L-Ascorbic Acid (12 total)、U.S. Production: 2023: 400、000 - <550、000 lb、2022: 700、000 - <850、2021: 700、2020: 2、500、000 - <4、000、(1972) 7.08 X 10+9 g、In 1979、ca 10、000 metric tons、yr of L-ascorbic acid was produced.、(1992) Europe > 20、000 tons per year、World approx 46、CHEMICAL PROFILE: Ascorbic acid. US Production Capacity: 1986: 32 million pounds、year.、For more U.S. Production (Complete) data for L-Ascorbic Acid (11 total)、U.S. Imports: (1972) 2.5 X 10+9 g、(1975) 2.13X10+9 g (including salts)、CHEMICAL PROFILE: Ascorbic acid. US Imports: 1989: about 13 million pounds.、CHEMICAL PROFILE: Ascorbic acid. US Imports: 1992: roughly 8-12 million pounds.、For more U.S. Imports (Complete) data for L-Ascorbic Acid (6 total)、U.S. Exports: (1972) 2.27 X 10+8 g、(1975) 7.76 X 10+7 g、CHEMICAL PROFILE: |
登记用途：Uses: CIR ingredient: L-Ascorbic Acid、CIR ingredient: Ascorbic Acid、An antioxidant essential in the human diet、Used as an antioxidant for foods and therapeutic vitamin、[Merck Index] Used as an antioxidant and pH adjustor in cosmetics (over 75% in hair dyes and colors)、for abscission of citrus fruit in harvesting、as a reducing agent in analytical chemistry、skin protectant、and UV sunscreen、[HSDB] Used in chemical synthesis、[IUCLID] Used as flavoring agent、antimicrobial agent、antioxidant、dough strengthener、nutritional supplement、pH control agent、sequestrant、and stabilizer or thickener for foods、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Dietary supplement、As antimicrobial and antioxidant in foodstuffs、Nutrition、color fixing、flavoring and preservative in meats and other foods、oxidant in bread dough、abscission of citrus fruit in harvesting、reducing agent in analytical chemistry、The iron、calcium、and sodium salts are available for biochemical research.、For more Uses (Complete) data for L-Ascorbic Acid (12 total)、please visit the HSDB record page.、Use Classification: EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives、Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern、Fragrance Ingredients、Food Additives -> ANTIOXIDANT -> JECFA Functional Classes、Cosmetics -> Buffering、Antioxidant、Industry Uses: Intermediate、Not Known or Reasonably Ascertainable、Consumer Uses: Not Known or Reasonably Ascertainable、Anti-stain agent、Other、Household Products: Information on 30 consumer products that contain Ascorbic Acid (Vitamin C) in the following categories is provided:、• Personal Care、• Pet Care、Information on 252 consumer products that contain Ascorbic acid in the following categories is provided:、Methods of Manufacturing: The classical Reichstein - Grussner synthesis starts with reduction of D-glucose to D-sorbitol by hydrogenation over a nickel catalyst. The microbiological oxidation of D-sorbitol to L-sorbose is carried out with Acetobacter xylinum. On treatment of L-sorbose with acetone at low temperature in the presence of sulfuric acid、2、3:4、6-di-O-isopropylidene-alpha-L-sorbofuranose is formed. The di-O-isopropylidenyl protection of the hydroxyl-groups at C-2、C-3 and C-4、C-6 allows high-yield oxidation to di-O-isopropylidene-2-ketogulonic acid、without over-oxidation or other side reactions. The oxidation is carried out with potassium permanganate in alkaline solution. Treatment of、di-O-isopropylidene-2-ketogulonic acid、with hot water affords 2-keto-L-gulonic acid、which is converted to L-ascorbic acid by heating in water at 100 °C (20% yield) or by esterification and treatment with sodium methoxide in methanol followed by acidification with hydrogen chloride、yielding ca. 70% of、L-ascorbic acid、. The overall yield of ascorbic acid from D-glucose is 15-18%.、Impurities: Oxalic acid < 0.2%、Heavy metals (as Pb): < 10 mg、kg、Formulations、Preparations: Ascorbic Acid (various manufacturers) Injection: 500 mg、mL、In 50 mL vials. Ascor L 500 (McGuff) Injection: 500 mg、0.025% EDTA. Preservative-free. In 50 mL.、Ascorbic Acid (as Ascorbic Acid or Sodium Ascorbate): Bulk: Powder. Oral: Capsules、extended-release 250 mg 500 mg. Lozenges 60 mg、Solution 25 mg、drop、100 mg、500 mg、5 mL. Tablets: 100 mg、250 mg、1 g. Tablets、chewable、1 g. Tablets、extended-release: 500 mg、1 g. 1.5 g. (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name.)、Ascorbic acid and sodium ascorbate are also commercially available in combination with other vitamins、minerals、amino acids、analgesic-antipyretics、anticholinergics、antihistamines、anti-inflammatory agents、cerebral stimulants、cough suppressants、enzymes、expectorants、hormones、infant formulas、keratolytic agents、laxatives、protein supplements、sedatives、and sympathomimetics. For iv infusion、ascorbic acid or sodium ascorbate is also commercially available in combination with other vitamins in caloric and electrolyte solutions.、Grades: USP、FCC[Lewis RJ Sr、Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007)、Consumption Patterns: CHEMICAL PROFILE: Ascorbic Acid. US End-use Pattern for Ascorbic Acid in 1986.、Table: US End-use pattern for ascorbic acid in 1986. [Table#2222]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1989.、Table: US End-use pattern for ascorbic acid in 1989 [Table#2223]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1992.、Table: US End-use pattern for ascorbic acid in 1992 [Table#2224]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1995.、Table: US End-use pattern for ascorbic acid in 1995 [Table#2225]、For more Consumption Patterns (Complete) data for L-Ascorbic Acid (12 total)、U.S. Production: 2023: 400、000 - <550、000 lb、2022: 700、000 - <850、2021: 700、2020: 2、500、000 - <4、000、(1972) 7.08 X 10+9 g、In 1979、ca 10、000 metric tons、yr of L-ascorbic acid was produced.、(1992) Europe > 20、000 tons per year、World approx 46、CHEMICAL PROFILE: Ascorbic acid. US Production Capacity: 1986: 32 million pounds、year.、For more U.S. Production (Complete) data for L-Ascorbic Acid (11 total)、U.S. Imports: (1972) 2.5 X 10+9 g、(1975) 2.13X10+9 g (including salts)、CHEMICAL PROFILE: Ascorbic acid. US Imports: 1989: about 13 million pounds.、CHEMICAL PROFILE: Ascorbic acid. US Imports: 1992: roughly 8-12 million pounds.、For more U.S. Imports (Complete) data for L-Ascorbic Acid (6 total)、U.S. Exports: (1972) 2.27 X 10+8 g、(1975) 7.76 X 10+7 g、CHEMICAL PROFILE:。
Vitamin C 是一种化工化合物，登记 CAS 号为 50-81-7，分子式 C6H8O6（分子量 176.03 g/mol）。
登记 CAS 号：50-81-7
其分子式 C6H8O6 由 6 个碳、8 个氢、6 个氧 组成。
别名/同义词：Vitamin C · L(+)-Ascorbic acid · Ascorbic acid
Vitamin C 的 CAS 登记号为 50-81-7。
分子式 C6H8O6，分子量 176.03 g/mol。
别名/同义词：Vitamin C、L(+)-Ascorbic acid、Ascorbic acid。
登记用途：Uses: CIR ingredient: L-Ascorbic Acid、CIR ingredient: Ascorbic Acid、An antioxidant essential in the human diet、Used as an antioxidant for foods and therapeutic vitamin、[Merck Index] Used as an antioxidant and pH adjustor in cosmetics (over 75% in hair dyes and colors)、for abscission of citrus fruit in harvesting、as a reducing agent in analytical chemistry、skin protectant、and UV sunscreen、[HSDB] Used in chemical synthesis、[IUCLID] Used as flavoring agent、antimicrobial agent、antioxidant、dough strengthener、nutritional supplement、pH control agent、sequestrant、and stabilizer or thickener for foods、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Dietary supplement、As antimicrobial and antioxidant in foodstuffs、Nutrition、color fixing、flavoring and preservative in meats and other foods、oxidant in bread dough、abscission of citrus fruit in harvesting、reducing agent in analytical chemistry、The iron、calcium、and sodium salts are available for biochemical research.、For more Uses (Complete) data for L-Ascorbic Acid (12 total)、please visit the HSDB record page.、Use Classification: EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives、Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern、Fragrance Ingredients、Food Additives -> ANTIOXIDANT -> JECFA Functional Classes、Cosmetics -> Buffering、Antioxidant、Industry Uses: Intermediate、Not Known or Reasonably Ascertainable、Consumer Uses: Not Known or Reasonably Ascertainable、Anti-stain agent、Other、Household Products: Information on 30 consumer products that contain Ascorbic Acid (Vitamin C) in the following categories is provided:、• Personal Care、• Pet Care、Information on 252 consumer products that contain Ascorbic acid in the following categories is provided:、Methods of Manufacturing: The classical Reichstein - Grussner synthesis starts with reduction of D-glucose to D-sorbitol by hydrogenation over a nickel catalyst. The microbiological oxidation of D-sorbitol to L-sorbose is carried out with Acetobacter xylinum. On treatment of L-sorbose with acetone at low temperature in the presence of sulfuric acid、2、3:4、6-di-O-isopropylidene-alpha-L-sorbofuranose is formed. The di-O-isopropylidenyl protection of the hydroxyl-groups at C-2、C-3 and C-4、C-6 allows high-yield oxidation to di-O-isopropylidene-2-ketogulonic acid、without over-oxidation or other side reactions. The oxidation is carried out with potassium permanganate in alkaline solution. Treatment of、di-O-isopropylidene-2-ketogulonic acid、with hot water affords 2-keto-L-gulonic acid、which is converted to L-ascorbic acid by heating in water at 100 °C (20% yield) or by esterification and treatment with sodium methoxide in methanol followed by acidification with hydrogen chloride、yielding ca. 70% of、L-ascorbic acid、. The overall yield of ascorbic acid from D-glucose is 15-18%.、Impurities: Oxalic acid < 0.2%、Heavy metals (as Pb): < 10 mg、kg、Formulations、Preparations: Ascorbic Acid (various manufacturers) Injection: 500 mg、mL、In 50 mL vials. Ascor L 500 (McGuff) Injection: 500 mg、0.025% EDTA. Preservative-free. In 50 mL.、Ascorbic Acid (as Ascorbic Acid or Sodium Ascorbate): Bulk: Powder. Oral: Capsules、extended-release 250 mg 500 mg. Lozenges 60 mg、Solution 25 mg、drop、100 mg、500 mg、5 mL. Tablets: 100 mg、250 mg、1 g. Tablets、chewable、1 g. Tablets、extended-release: 500 mg、1 g. 1.5 g. (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name.)、Ascorbic acid and sodium ascorbate are also commercially available in combination with other vitamins、minerals、amino acids、analgesic-antipyretics、anticholinergics、antihistamines、anti-inflammatory agents、cerebral stimulants、cough suppressants、enzymes、expectorants、hormones、infant formulas、keratolytic agents、laxatives、protein supplements、sedatives、and sympathomimetics. For iv infusion、ascorbic acid or sodium ascorbate is also commercially available in combination with other vitamins in caloric and electrolyte solutions.、Grades: USP、FCC[Lewis RJ Sr、Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007)、Consumption Patterns: CHEMICAL PROFILE: Ascorbic Acid. US End-use Pattern for Ascorbic Acid in 1986.、Table: US End-use pattern for ascorbic acid in 1986. [Table#2222]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1989.、Table: US End-use pattern for ascorbic acid in 1989 [Table#2223]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1992.、Table: US End-use pattern for ascorbic acid in 1992 [Table#2224]、CHEMICAL PROFILE: Ascorbic acid. US End-use Pattern for Ascorbic Acid in 1995.、Table: US End-use pattern for ascorbic acid in 1995 [Table#2225]、For more Consumption Patterns (Complete) data for L-Ascorbic Acid (12 total)、U.S. Production: 2023: 400、000 - <550、000 lb、2022: 700、000 - <850、2021: 700、2020: 2、500、000 - <4、000、(1972) 7.08 X 10+9 g、In 1979、ca 10、000 metric tons、yr of L-ascorbic acid was produced.、(1992) Europe > 20、000 tons per year、World approx 46、CHEMICAL PROFILE: Ascorbic acid. US Production Capacity: 1986: 32 million pounds、year.、For more U.S. Production (Complete) data for L-Ascorbic Acid (11 total)、U.S. Imports: (1972) 2.5 X 10+9 g、(1975) 2.13X10+9 g (including salts)、CHEMICAL PROFILE: Ascorbic acid. US Imports: 1989: about 13 million pounds.、CHEMICAL PROFILE: Ascorbic acid. US Imports: 1992: roughly 8-12 million pounds.、For more U.S. Imports (Complete) data for L-Ascorbic Acid (6 total)、U.S. Exports: (1972) 2.27 X 10+8 g、(1975) 7.76 X 10+7 g、CHEMICAL PROFILE:。
Vitamin C（CAS 50-81-7）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 50-81-7 |
|---|---|
| PubChem CID | 54670067 |
| 分子式 | C6H8O6 |
| 分子量 | 176.03 g/mol |
| IUPAC 名称 | (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one |
| InChIKey | CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
| UNII（FDA） | PQ6CK8PD0R |
| ChEBI 编号 | CHEBI:29073 |
| ATC 编码（WHO） | A11G |
| FEMA 编号 | 2109 |
| Molecular Weight | 176.12 |
|---|---|
| XLogP3 | -1.6 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 176.03208797 |
| Monoisotopic Mass | 176.03208797 |
| Topological Polar Surface Area | 107 |
| Heavy Atom Count | 12 |
| Melting Point | 191 |
|---|---|
| Melting Point | 191 °C |
| Solubility | 400000 |
| Solubility | 400 mg/mL at 40 °C |
| Density | 1.65 g/cu cm at 25 °C |
| Density | Density (at 25 °C): 1.65 g/cm³ |
| LogP | -1.85 |
| LogP | log Kow = -1.85 |
| LogP | -2.15 |
| LogP | -1.84 |
l-ascorbic acid; ascorbic acid; vitamin C; 50-81-7; L(+)-Ascorbic acid; Ascoltin; Ascorbicap; Cevitamic acid; Allercorb; Ascorbajen; Ascorin; Ascorteal; Ascorvit; Cantaxin; Cebicure; Cegiolan
| 法规与食品接触 | FDA Substance added to food: ANTIMICROBIAL AGENT, ANTIOXIDANT, COLOR OR COLORING ADJUNCT, DOUGH STRENGTHENER, ANTIOXIDANT: Food Additives ANTIMICROBIAL AGENT, ANTIOXIDANT, COLOR OR COLORING ADJUNCT, DOUGH STRENGTHENER, FLAVOR ENHANCER, FLAVORING AG 维生素 C（水果和蔬菜衍生） 旨在用作按照 wi 使用的其他市售形式的抗坏血酸的替代品 Scientific procedures |
|---|---|
| GHS 通报统计 | 97.3% (572 / 588) |
| GHS 通报统计 | 97.3% (572 / 588) |
|---|
L(+)-抗坏血酸 的 CAS 号为 50-81-7，分子式 C6H8O6，分子量 176.03 g/mol。 UNII PQ6CK8PD0R; ChEBI 29073; InChIKey CIWBSHSKHKDKBQ-JLAZNSOCSA-N. Melting Point: 191; Melting Point: 191 °C; Solubility: 400000.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Vitamin C