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Vitamin B3

CAS 59-67-6C6H5NO2MW 123.03 g/mol

Vitamin B3(CAS 59-67-6):分子式 C6H5NO2、分子量 123.03 g/mol。

产品概览

CAS号59-67-6
分子式C6H5NO2
分子量123.03 g/mol
熔点457 °F (NTP, 1992)
沸点292.4
LogP0.4
应用领域Uses: CIR ingredient: Niacin、Occurs naturally especially in liver、fish、yeast、and cereal grains、Used as a drug (antilipemic and vitamin)、[Merck Index] Used in the chemical、agricultural、animal feed、and food industries、in cosmetics、pharmaceuticals、as a food additive、intermediate、and laboratory chemical、[IUCLID] Used as a medication、nutrient、in animal feeds、enriched flours、as a chemical intermediate、and in electroplating bathes、[HSDB] Used as a nutritional supplement、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Electroplating [Category: Plate]、Farming (Feed Additives) [Category: Industry]、Hypolipidemic Agents、Vasodilator Agents、Vitamin B Complex、For nicotinic acid (USEPA、OPP Pesticide Code: 056701) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Medicine (cholesterol-lowering agent)、nutrition、feeds、dietary supplement、...、Has、been used in the enrichment of bread、flour、and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid ... .、For more Uses (Complete) data for Nicotinic acid (8 total)、please visit the HSDB record page.、Synthetic Polymer MALDI Matrix Compounds、Use (kg、approx.) in Germany (2009): >2500、Use (kg) in USA (2002): 97300、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Consumption (g per capita) in the USA (2002): 0.345、Calculated removal (%): 92.1、For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy. It can be found in various foods、such as liver、chicken、beef、cereal、peanuts and legumes. Niacin is also used as a pharmaceutical to reverse atherosclerosis. (A729)、Use Classification: Cosmetics -> Smoothing、Antistatic、Industry Uses: Flavoring and nutrient、Intermediate、Consumer Uses: Flavoring and nutrient、Household Products: Information on 1 consumer products that contain Niacin in the following categories is provided:、• Personal Care、Methods of Manufacturing: In an aqueous solution 5-ethyl-2-methylpyridine is oxidized to nicotinic acid in a single-tube reactor by using an excess of nitric acid. The continuous process takes place at 230-270 °C and 6-8 MPa. Pyridine-2、5-dicarboxylic acid is formed as an intermediate、but is not stable under the reaction conditions、undergoing decarboxylation to nicotinic acid nitrate. Neutralization of the nitrate with 5-ethyl-2-methylpyridine yields nicotinic acid. Water and carbon dioxide formed in the reaction are separated from the product. The nitrogen oxide formed is oxidized with air to nitrogen dioxide and then absorbed in water to yield nitric acid、which is recycled into the process.、Preparation by oxidation of alkyl beta-substituted pyridines、Preparation by oxidation of nicotine、Commercial sources: Synthetic nicotinic acid is made by oxidation of nicotine、quinoline、or 2-methyl-5-ethylpyridine (from ammonia and formaldehyde or acetaldehyde).、Formulations、Preparations: Table: Niacin Preparations [Table#4463]、Table: Niacin Combination Preparations [Table#4464]、Table: Niacin Preparations [Table#4465]、Grades: National Formulary、Food Chemical Codex、blended with soy flour (animal feeds)、Niacin is commercially available as conventional (immediate-release) and extended-release preparations and in fixed combination with lovastatin. Niacin also is available as a dietary supplement、these preparations are not FDA-labeled for management of dyslipidemias and should not be used as substitutes for prescription-only niacin preparations.、U.S. Production: 2023: 235、012 lb、2022: 334、132 lb、2021: 710、858 lb、2020: 396、391 lb、(1972) 2.49X10+9 GRAMS、NIACIN & NICOTINAMIDE、(1975) 2.5X10+9 GRAMS、Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Nicotinic acid:、Table: National Aggregate Production Volume (pounds) [Table#4468]、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Food、beverage、and tobacco product manufacturing、Other (requires additional information)、3-Pyridinecarboxylic acid: ACTIVE、Niacin is a naturally occurring substance. Nicotinic acid is the form present in food of plant origin、whereas nicotinamide occurs in animal products.、The terms niacin、Vitamin B3、and Vitamin PP have been used to refer to both nicotinamide and nicotinic acid.、NIACIN、MOST STABLE OF VIT、IS NOT DESTROYED BY HEATING IN ACID OR ALKALINE SOLN. IT WITHSTANDS MILD OXIDATION、& RETAINS ITS BIOLOGICAL ACTIVITY DURING PROCESSING OF FOOD & PREPN & STORAGE OF PHARMACEUTICALS.、RECOMMENDED ALLOWANCE OF THE DIETARY ALLOWANCES COMMITTEE OF THE NATIONAL RESEARCH COUNCIL、EXPRESSED IN NICOTINIC ACID EQUIVALENTS、IS 6.6 MG、1000 KCAL.

应用领域

登记用途:Uses: CIR ingredient: Niacin、Occurs naturally especially in liver、fish、yeast、and cereal grains、Used as a drug (antilipemic and vitamin)、[Merck Index] Used in the chemical、agricultural、animal feed、and food industries、in cosmetics、pharmaceuticals、as a food additive、intermediate、and laboratory chemical、[IUCLID] Used as a medication、nutrient、in animal feeds、enriched flours、as a chemical intermediate、and in electroplating bathes、[HSDB] Used as a nutritional supplement、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Electroplating [Category: Plate]、Farming (Feed Additives) [Category: Industry]、Hypolipidemic Agents、Vasodilator Agents、Vitamin B Complex、For nicotinic acid (USEPA、OPP Pesticide Code: 056701) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Medicine (cholesterol-lowering agent)、nutrition、feeds、dietary supplement、...、Has、been used in the enrichment of bread、flour、and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid ... .、For more Uses (Complete) data for Nicotinic acid (8 total)、please visit the HSDB record page.、Synthetic Polymer MALDI Matrix Compounds、Use (kg、approx.) in Germany (2009): >2500、Use (kg) in USA (2002): 97300、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Consumption (g per capita) in the USA (2002): 0.345、Calculated removal (%): 92.1、For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy. It can be found in various foods、such as liver、chicken、beef、cereal、peanuts and legumes. Niacin is also used as a pharmaceutical to reverse atherosclerosis. (A729)、Use Classification: Cosmetics -> Smoothing、Antistatic、Industry Uses: Flavoring and nutrient、Intermediate、Consumer Uses: Flavoring and nutrient、Household Products: Information on 1 consumer products that contain Niacin in the following categories is provided:、• Personal Care、Methods of Manufacturing: In an aqueous solution 5-ethyl-2-methylpyridine is oxidized to nicotinic acid in a single-tube reactor by using an excess of nitric acid. The continuous process takes place at 230-270 °C and 6-8 MPa. Pyridine-2、5-dicarboxylic acid is formed as an intermediate、but is not stable under the reaction conditions、undergoing decarboxylation to nicotinic acid nitrate. Neutralization of the nitrate with 5-ethyl-2-methylpyridine yields nicotinic acid. Water and carbon dioxide formed in the reaction are separated from the product. The nitrogen oxide formed is oxidized with air to nitrogen dioxide and then absorbed in water to yield nitric acid、which is recycled into the process.、Preparation by oxidation of alkyl beta-substituted pyridines、Preparation by oxidation of nicotine、Commercial sources: Synthetic nicotinic acid is made by oxidation of nicotine、quinoline、or 2-methyl-5-ethylpyridine (from ammonia and formaldehyde or acetaldehyde).、Formulations、Preparations: Table: Niacin Preparations [Table#4463]、Table: Niacin Combination Preparations [Table#4464]、Table: Niacin Preparations [Table#4465]、Grades: National Formulary、Food Chemical Codex、blended with soy flour (animal feeds)、Niacin is commercially available as conventional (immediate-release) and extended-release preparations and in fixed combination with lovastatin. Niacin also is available as a dietary supplement、these preparations are not FDA-labeled for management of dyslipidemias and should not be used as substitutes for prescription-only niacin preparations.、U.S. Production: 2023: 235、012 lb、2022: 334、132 lb、2021: 710、858 lb、2020: 396、391 lb、(1972) 2.49X10+9 GRAMS、NIACIN & NICOTINAMIDE、(1975) 2.5X10+9 GRAMS、Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Nicotinic acid:、Table: National Aggregate Production Volume (pounds) [Table#4468]、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Food、beverage、and tobacco product manufacturing、Other (requires additional information)、3-Pyridinecarboxylic acid: ACTIVE、Niacin is a naturally occurring substance. Nicotinic acid is the form present in food of plant origin、whereas nicotinamide occurs in animal products.、The terms niacin、Vitamin B3、and Vitamin PP have been used to refer to both nicotinamide and nicotinic acid.、NIACIN、MOST STABLE OF VIT、IS NOT DESTROYED BY HEATING IN ACID OR ALKALINE SOLN. IT WITHSTANDS MILD OXIDATION、& RETAINS ITS BIOLOGICAL ACTIVITY DURING PROCESSING OF FOOD & PREPN & STORAGE OF PHARMACEUTICALS.、RECOMMENDED ALLOWANCE OF THE DIETARY ALLOWANCES COMMITTEE OF THE NATIONAL RESEARCH COUNCIL、EXPRESSED IN NICOTINIC ACID EQUIVALENTS、IS 6.6 MG、1000 KCAL.。

技术档案

这个产品是什么

Vitamin B3 是一种化工化合物,登记 CAS 号为 59-67-6,分子式 C6H5NO2(分子量 123.03 g/mol)。

识别信息

登记 CAS 号:59-67-6

其分子式 C6H5NO2 由 6 个碳、5 个氢、1 个氮、2 个氧 组成。

别名/同义词:Vitamin B3 · Nicotinic acid

常见问题

Vitamin B3 的 CAS 号是多少?

Vitamin B3 的 CAS 登记号为 59-67-6。

Vitamin B3 的分子式与分子量是多少?

分子式 C6H5NO2,分子量 123.03 g/mol。

Vitamin B3 还有哪些别名?

别名/同义词:Vitamin B3、Nicotinic acid。

Vitamin B3 的登记用途是什么?

登记用途:Uses: CIR ingredient: Niacin、Occurs naturally especially in liver、fish、yeast、and cereal grains、Used as a drug (antilipemic and vitamin)、[Merck Index] Used in the chemical、agricultural、animal feed、and food industries、in cosmetics、pharmaceuticals、as a food additive、intermediate、and laboratory chemical、[IUCLID] Used as a medication、nutrient、in animal feeds、enriched flours、as a chemical intermediate、and in electroplating bathes、[HSDB] Used as a nutritional supplement、[FDA] Permitted for use as an inert ingredient in non-food pesticide products、[EPA]、Electroplating [Category: Plate]、Farming (Feed Additives) [Category: Industry]、Hypolipidemic Agents、Vasodilator Agents、Vitamin B Complex、For nicotinic acid (USEPA、OPP Pesticide Code: 056701) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Medicine (cholesterol-lowering agent)、nutrition、feeds、dietary supplement、...、Has、been used in the enrichment of bread、flour、and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid ... .、For more Uses (Complete) data for Nicotinic acid (8 total)、please visit the HSDB record page.、Synthetic Polymer MALDI Matrix Compounds、Use (kg、approx.) in Germany (2009): >2500、Use (kg) in USA (2002): 97300、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Consumption (g per capita) in the USA (2002): 0.345、Calculated removal (%): 92.1、For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy. It can be found in various foods、such as liver、chicken、beef、cereal、peanuts and legumes. Niacin is also used as a pharmaceutical to reverse atherosclerosis. (A729)、Use Classification: Cosmetics -> Smoothing、Antistatic、Industry Uses: Flavoring and nutrient、Intermediate、Consumer Uses: Flavoring and nutrient、Household Products: Information on 1 consumer products that contain Niacin in the following categories is provided:、• Personal Care、Methods of Manufacturing: In an aqueous solution 5-ethyl-2-methylpyridine is oxidized to nicotinic acid in a single-tube reactor by using an excess of nitric acid. The continuous process takes place at 230-270 °C and 6-8 MPa. Pyridine-2、5-dicarboxylic acid is formed as an intermediate、but is not stable under the reaction conditions、undergoing decarboxylation to nicotinic acid nitrate. Neutralization of the nitrate with 5-ethyl-2-methylpyridine yields nicotinic acid. Water and carbon dioxide formed in the reaction are separated from the product. The nitrogen oxide formed is oxidized with air to nitrogen dioxide and then absorbed in water to yield nitric acid、which is recycled into the process.、Preparation by oxidation of alkyl beta-substituted pyridines、Preparation by oxidation of nicotine、Commercial sources: Synthetic nicotinic acid is made by oxidation of nicotine、quinoline、or 2-methyl-5-ethylpyridine (from ammonia and formaldehyde or acetaldehyde).、Formulations、Preparations: Table: Niacin Preparations [Table#4463]、Table: Niacin Combination Preparations [Table#4464]、Table: Niacin Preparations [Table#4465]、Grades: National Formulary、Food Chemical Codex、blended with soy flour (animal feeds)、Niacin is commercially available as conventional (immediate-release) and extended-release preparations and in fixed combination with lovastatin. Niacin also is available as a dietary supplement、these preparations are not FDA-labeled for management of dyslipidemias and should not be used as substitutes for prescription-only niacin preparations.、U.S. Production: 2023: 235、012 lb、2022: 334、132 lb、2021: 710、858 lb、2020: 396、391 lb、(1972) 2.49X10+9 GRAMS、NIACIN & NICOTINAMIDE、(1975) 2.5X10+9 GRAMS、Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Nicotinic acid:、Table: National Aggregate Production Volume (pounds) [Table#4468]、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Food、beverage、and tobacco product manufacturing、Other (requires additional information)、3-Pyridinecarboxylic acid: ACTIVE、Niacin is a naturally occurring substance. Nicotinic acid is the form present in food of plant origin、whereas nicotinamide occurs in animal products.、The terms niacin、Vitamin B3、and Vitamin PP have been used to refer to both nicotinamide and nicotinic acid.、NIACIN、MOST STABLE OF VIT、IS NOT DESTROYED BY HEATING IN ACID OR ALKALINE SOLN. IT WITHSTANDS MILD OXIDATION、& RETAINS ITS BIOLOGICAL ACTIVITY DURING PROCESSING OF FOOD & PREPN & STORAGE OF PHARMACEUTICALS.、RECOMMENDED ALLOWANCE OF THE DIETARY ALLOWANCES COMMITTEE OF THE NATIONAL RESEARCH COUNCIL、EXPRESSED IN NICOTINIC ACID EQUIVALENTS、IS 6.6 MG、1000 KCAL.。

PubChem 公开数据

Vitamin B3(CAS 59-67-6)的独立参考数据,整理自公开化学数据库。

各数据库的登记标识

CAS 号59-67-6
PubChem CID938
分子式C6H5NO2
分子量123.03 g/mol
IUPAC 名称pyridine-3-carboxylic acid
InChIKeyPVNIIMVLHYAWGP-UHFFFAOYSA-N
UNII(FDA)2679MF687A
ChEBI 编号CHEBI:15940
ATC 编码(WHO)C04AC01

计算分子描述符

Molecular Weight123.11
XLogP30.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass123.032028402
Monoisotopic Mass123.032028402
Topological Polar Surface Area50.2
Heavy Atom Count9

在册的理化数值

Boiling Point292.4
Melting Point457 °F (NTP, 1992)
Melting Point236-239
Melting Point237 °C
Melting Point236.6 °C
Flash Point193 °C (379 °F) - closed cup
Flash Point193 °C c.c.
Solubility10 to 50 mg/mL at 63 °F (NTP, 1992)
Solubility18000
SolubilityIn water, 1.8X10+4 mg/L at 20 °C

同义词与商品名

nicotinic acid; niacin; 59-67-6; Pyridine-3-carboxylic acid; 3-pyridinecarboxylic acid; 3-Carboxypyridine; Akotin; wampocap; Apelagrin; Pellagrin; Daskil; Efacin; Niaspan; Pelonin; Linic; Nicyl

已收录的法规名录

法规与食品接触FDA Substance added to food: NUTRIENT SUPPLEMENT
CIR / INCI: Cosmetic ingredients (Niacin) -> CIR (Cosmetic Ingredient Review)
CIR / INCI: Antistatic; Smoothing

GHS 危害分类

已通报的危害声明H319 (99.8%), H402

公开数据库对它的描述

烟酸 的 CAS 号为 59-67-6,分子式 C6H5NO2,分子量 123.03 g/mol。 UNII 2679MF687A; ChEBI 15940; InChIKey PVNIIMVLHYAWGP-UHFFFAOYSA-N. Boiling Point: 292.4; Melting Point: 457 °F (NTP, 1992); Melting Point: 236-239.

数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。

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