长春新碱（CAS 57-22-7）：分子式 C46H56N4O10、分子量 825.0。
| CAS号 | 57-22-7 |
|---|---|
| 分子式 | C46H56N4O10 |
| 分子量 | 825.0 |
| 熔点 | 424 to 428 °F (NTP, 1992) |
| LogP | 2.82 |
| 应用领域 | Uses: ... in the treatment of acute leukemia in children、Vincristine sulfate USP、MEDICATION (VET)、MEDICATION、Therapeutic Category: Antineoplastic、Treatment of acute lymphocytic leukemia (ALL)、Hodgkin lymphoma、non-Hodgkin lymphomas、Wilms' tumor、neuroblastoma、rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).、Methods of Manufacturing: Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine、and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid.、Isolation from Vinca rosea Linn (Catharanthus roseus G Don)、Apocynaceae.、USING SUITABLE MODIFICATIONS IN CHROMATOGRAPHIC PART OF PROCESS、VINCRISTINE SULFATE ISOLATING ALKALOID FROM EXTRACT BY USUAL PPT & SOLVENT TECHNIQUES & PURIFYING BY CHROMATOGRAPHY ON ALUMINUM OXIDE. CONVERSION TO SULFATE BY、ADDN OF SULFURIC ACID、... .、VINCRISTINE SULFATE、Impurities: 3'-hydroxyvincristine、4'-deoxyvincristine、N-desmethylvinblastine、deacetylvincristine、deacetylvinblastine、vinblastine、leurosine、formylleurosine、Formulations、Preparations: VINCRISTINE SULFATE、SUP (ONCOVIN)、IS AVAILABLE AS DRY POWDER IN AMPULS CONTAINING EITHER 1 OR 5 MG OF DRUG.、Parenteral Injection、for iv use only、1 mg、mL Vincristine Sulfate Injection (preservative-free)、Hospira、Teva、Vials and syringes、1、2、and 5 mg、Vincristine sulfate、General Manufacturing Information: For the treatment of acute leukemia、malignant lymphoma、Hodgkins disease、acute erythremia、acute panmyelosis |
登记用途：Uses: ... in the treatment of acute leukemia in children、Vincristine sulfate USP、MEDICATION (VET)、MEDICATION、Therapeutic Category: Antineoplastic、Treatment of acute lymphocytic leukemia (ALL)、Hodgkin lymphoma、non-Hodgkin lymphomas、Wilms' tumor、neuroblastoma、rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).、Methods of Manufacturing: Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine、and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid.、Isolation from Vinca rosea Linn (Catharanthus roseus G Don)、Apocynaceae.、USING SUITABLE MODIFICATIONS IN CHROMATOGRAPHIC PART OF PROCESS、VINCRISTINE SULFATE ISOLATING ALKALOID FROM EXTRACT BY USUAL PPT & SOLVENT TECHNIQUES & PURIFYING BY CHROMATOGRAPHY ON ALUMINUM OXIDE. CONVERSION TO SULFATE BY、ADDN OF SULFURIC ACID、... .、VINCRISTINE SULFATE、Impurities: 3'-hydroxyvincristine、4'-deoxyvincristine、N-desmethylvinblastine、deacetylvincristine、deacetylvinblastine、vinblastine、leurosine、formylleurosine、Formulations、Preparations: VINCRISTINE SULFATE、SUP (ONCOVIN)、IS AVAILABLE AS DRY POWDER IN AMPULS CONTAINING EITHER 1 OR 5 MG OF DRUG.、Parenteral Injection、for iv use only、1 mg、mL Vincristine Sulfate Injection (preservative-free)、Hospira、Teva、Vials and syringes、1、2、and 5 mg、Vincristine sulfate、General Manufacturing Information: For the treatment of acute leukemia、malignant lymphoma、Hodgkins disease、acute erythremia、acute panmyelosis。
长春新碱 是一种化工化合物，登记 CAS 号为 57-22-7，分子式 C46H56N4O10（分子量 825.0）。
登记 CAS 号：57-22-7
其分子式 C46H56N4O10 由 46 个碳、56 个氢、4 个氮、10 个氧 组成。
别名/同义词：长春新碱 · vincristine
长春新碱 的 CAS 登记号为 57-22-7。
分子式 C46H56N4O10，分子量 825.0。
别名/同义词：长春新碱、vincristine。
登记用途：Uses: ... in the treatment of acute leukemia in children、Vincristine sulfate USP、MEDICATION (VET)、MEDICATION、Therapeutic Category: Antineoplastic、Treatment of acute lymphocytic leukemia (ALL)、Hodgkin lymphoma、non-Hodgkin lymphomas、Wilms' tumor、neuroblastoma、rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).、Methods of Manufacturing: Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine、and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid.、Isolation from Vinca rosea Linn (Catharanthus roseus G Don)、Apocynaceae.、USING SUITABLE MODIFICATIONS IN CHROMATOGRAPHIC PART OF PROCESS、VINCRISTINE SULFATE ISOLATING ALKALOID FROM EXTRACT BY USUAL PPT & SOLVENT TECHNIQUES & PURIFYING BY CHROMATOGRAPHY ON ALUMINUM OXIDE. CONVERSION TO SULFATE BY、ADDN OF SULFURIC ACID、... .、VINCRISTINE SULFATE、Impurities: 3'-hydroxyvincristine、4'-deoxyvincristine、N-desmethylvinblastine、deacetylvincristine、deacetylvinblastine、vinblastine、leurosine、formylleurosine、Formulations、Preparations: VINCRISTINE SULFATE、SUP (ONCOVIN)、IS AVAILABLE AS DRY POWDER IN AMPULS CONTAINING EITHER 1 OR 5 MG OF DRUG.、Parenteral Injection、for iv use only、1 mg、mL Vincristine Sulfate Injection (preservative-free)、Hospira、Teva、Vials and syringes、1、2、and 5 mg、Vincristine sulfate、General Manufacturing Information: For the treatment of acute leukemia、malignant lymphoma、Hodgkins disease、acute erythremia、acute panmyelosis。
长春新碱（CAS 57-22-7）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 57-22-7 |
|---|---|
| PubChem CID | 5978 |
| Molecular formula | C46H56N4O10 |
| UNII (FDA) | 5J49Q6B70F |
| Molecular Weight | 825.0 |
|---|---|
| XLogP3 | 2.8 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 10 |
| Exact Mass | 824.39964400 |
| Monoisotopic Mass | 824.39964400 |
| Topological Polar Surface Area | 171 |
| Heavy Atom Count | 60 |
| Melting Point | 424 to 428 °F (NTP, 1992) |
|---|---|
| Melting Point | 220 |
| Melting Point | 218-220 °C |
| Melting Point | 220 °C |
| Solubility | 3.00e-02 g/L |
| LogP | 2.82 |
| LogP | log Kow = 2.82 |
| LogP | 2.8 |
vincristine; 22-Oxovincaleukoblastine; Leurocristine; Vinkristin; 57-22-7; Vincrystine; Vincristina; leucristine; vincristin; Tecnocris; Onco TCS; Oncovine; Oncotcs; Vincristinum; DTXSID1032278; NSC-67574
vincristine · CAS 57-22-7 · C46H56N4O10. UNII 5J49Q6B70F. Melting Point: 424 to 428 °F (NTP, 1992); Melting Point: 220; Melting Point: 218-220 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: vincristine