维拉帕米

CAS 52-53-9C27H38N2O4MW 454.6

维拉帕米（CAS 52-53-9）：分子式 C27H38N2O4、分子量 454.6。

产品概览

CAS号	52-53-9
分子式	C27H38N2O4
分子量	454.6
熔点	< 25 °C
沸点	BP: 245 °C at 0.01 mm Hg
LogP	3.79
应用领域	Uses: Anti-Arrhythmia Agents、Calcium Channel Blockers、Vasodilator Agents、MEDICATION、Use (kg) in Switzerland (2009): >1000、Use (kg、approx.) in Germany (2009): >25000、Use (kg) in USA (2002): 207000、Consumption (g per capita) in Switzerland (2009): 0.13、Consumption (g per capita、approx.) in Germany (2009): 0.31、Consumption (g per capita) in the USA (2002): 0.73、Excretion rate: 0.2、Calculated removal (%): 21.5、Drug used for the treatment of hypertension、angina、and cluster headache prophylaxis.、Use Classification: Pharmaceuticals、Pharmaceuticals -> Cardiovascular system -> Calcium channel blockers -> Selective calcium channel blockers with direct cardiac effects -> Phenylalkylamine derivatives -> Calcium antagonists、Methods of Manufacturing: Preparation: Belgium patent 615861、Dengel、United States of America patent 3261859 (1962、1966 both to Knoll).、Veratryl chloride + isopropyl bromide + homoveratrylamine + 1-bromo-3-chloroporpane (dehydrobromination、methylation、amine formation、dehydrochlorination)、Formulations、Preparations: Trade Names: Isoptin (Knoll)、Securon (Knoll Ltd.)、Calan (Searle)、Cardibeltin (Pharma Schwarz)、Cordilox (Abbott)、all preparations contain verapamil hydrochloride.、Table: Verapamil Hydrochloride Preparations [Table#4670]、Table: Verapamil Hydrochloride Combinations [Table#4671]、General Manufacturing Information: Available commercially as the free base or hydrochloride、Ca2+ channel antgonist which is unrelated chemically to nifedipine and nitrendipine.

应用领域

登记用途：Uses: Anti-Arrhythmia Agents、Calcium Channel Blockers、Vasodilator Agents、MEDICATION、Use (kg) in Switzerland (2009): >1000、Use (kg、approx.) in Germany (2009): >25000、Use (kg) in USA (2002): 207000、Consumption (g per capita) in Switzerland (2009): 0.13、Consumption (g per capita、approx.) in Germany (2009): 0.31、Consumption (g per capita) in the USA (2002): 0.73、Excretion rate: 0.2、Calculated removal (%): 21.5、Drug used for the treatment of hypertension、angina、and cluster headache prophylaxis.、Use Classification: Pharmaceuticals、Pharmaceuticals -> Cardiovascular system -> Calcium channel blockers -> Selective calcium channel blockers with direct cardiac effects -> Phenylalkylamine derivatives -> Calcium antagonists、Methods of Manufacturing: Preparation: Belgium patent 615861、Dengel、United States of America patent 3261859 (1962、1966 both to Knoll).、Veratryl chloride + isopropyl bromide + homoveratrylamine + 1-bromo-3-chloroporpane (dehydrobromination、methylation、amine formation、dehydrochlorination)、Formulations、Preparations: Trade Names: Isoptin (Knoll)、Securon (Knoll Ltd.)、Calan (Searle)、Cardibeltin (Pharma Schwarz)、Cordilox (Abbott)、all preparations contain verapamil hydrochloride.、Table: Verapamil Hydrochloride Preparations [Table#4670]、Table: Verapamil Hydrochloride Combinations [Table#4671]、General Manufacturing Information: Available commercially as the free base or hydrochloride、Ca2+ channel antgonist which is unrelated chemically to nifedipine and nitrendipine.。

技术档案

这个产品是什么

维拉帕米是一种化工化合物，登记 CAS 号为 52-53-9，分子式 C27H38N2O4（分子量 454.6）。

识别信息

登记 CAS 号：52-53-9

其分子式 C27H38N2O4 由 27 个碳、38 个氢、2 个氮、4 个氧组成。

别名/同义词：维拉帕米 · Verapamil

常见问题

维拉帕米的 CAS 号是多少？

维拉帕米的 CAS 登记号为 52-53-9。

维拉帕米的分子式与分子量是多少？

分子式 C27H38N2O4，分子量 454.6。

维拉帕米还有哪些别名？

别名/同义词：维拉帕米、Verapamil。

维拉帕米的登记用途是什么？

PubChem 公开数据

维拉帕米（CAS 52-53-9）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

CAS Registry Number	52-53-9
PubChem CID	2520
Molecular formula	C27H38N2O4
IUPAC name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
UNII (FDA)	CJ0O37KU29

计算分子描述符

Molecular Weight	454.6
XLogP3	3.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	13
Exact Mass	454.28315770
Monoisotopic Mass	454.28315770
Topological Polar Surface Area	64
Heavy Atom Count	33

在册的理化数值

Boiling Point	BP: 245 °C at 0.01 mm Hg
Boiling Point	243-246 °C at 1.00E-02 mm Hg
Melting Point	< 25 °C
Solubility	4.47 mg/L
LogP	3.79
LogP	3.83
Dissociation Constants	9.07
Dissociation Constants	8.92
Dissociation Constants	pKa = 8.92
Collision Cross Section	203.4 Å² [M+H]+

在册的记载用途

同义词与商品名

VERAPAMIL; 52-53-9; Iproveratril; Dilacoran; Verapamilo; Cardibeltin; Verapamilum; Isoptine; Securon; D-365; Cardiagutt; Dignover; Veramex; Verpamil; Quasar; CP-16533-1

GHS 危害分类

Reported hazard statements	H301 (100%), H311 (100%), H331 (100%)

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]

公开数据库对它的描述

Verapamil · CAS 52-53-9 · C27H38N2O4. UNII CJ0O37KU29. Boiling Point: BP: 245 °C at 0.01 mm Hg; Boiling Point: 243-246 °C at 1.00E-02 mm Hg; Melting Point: < 25 °C.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。