Verapamil

Description

Verapamil · CAS 52-53-9 · C27H38N2O4. UNII CJ0O37KU29. Boiling Point: BP: 245 °C at 0.01 mm Hg; Boiling Point: 243-246 °C at 1.00E-02 mm Hg; Melting Point: < 25 °C.

Identification

CAS Registry Number	52-53-9
PubChem CID	2520
Molecular formula	C27H38N2O4
IUPAC name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
UNII (FDA)	CJ0O37KU29

Computed Descriptors

Molecular Weight	454.6
XLogP3	3.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	13
Exact Mass	454.28315770
Monoisotopic Mass	454.28315770
Topological Polar Surface Area	64
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Boiling Point	BP: 245 °C at 0.01 mm Hg
Boiling Point	243-246 °C at 1.00E-02 mm Hg
Melting Point	< 25 °C
Solubility	4.47 mg/L
LogP	3.79
LogP	3.83
Dissociation Constants	9.07
Dissociation Constants	8.92
Dissociation Constants	pKa = 8.92
Collision Cross Section	203.4 Ų [M+H]+

Physical description & handling notes

• Solid
• Viscous, pale yellow oil
• Solubility (mg/mL): water 83, ethanol (200 proof) 26, propylene glycol 93, ethanol (190 proof) >100, methanol >100, 2-propanol 4.6, ethyl acetate 1.0, DMF >100, methylene chloride >100, hexane 0.001; Freely soluble in chloroform, practically insoluble in ether /Verapamil hydrochloride/
• Practically insoluble in water
• Sparingly soluble in hexane; soluble in benzene, ether; freely soluble in the lower alcohols, acetone, ethyl acetate, chloroform
• log Kow = 3.79 at pH 9.0; log Kow = 2.15 at pH 7.0

GHS Hazard Classification

Reported hazard statements	H301 (100%), H311 (100%), H331 (100%)

Documented Uses

• Anti-Arrhythmia Agents; Calcium Channel Blockers; Vasodilator Agents
• Use (kg) in Switzerland (2009): >1000
• Use (kg; approx.) in Germany (2009): >25000
• Consumption (g per capita) in Switzerland (2009): 0.13
• Consumption (g per capita; approx.) in Germany (2009): 0.31
• Consumption (g per capita) in the USA (2002): 0.73

Synonyms

VERAPAMIL; 52-53-9; Iproveratril; Dilacoran; Verapamilo; Cardibeltin; Verapamilum; Isoptine; Securon; D-365; Cardiagutt; Dignover; Veramex; Verpamil; Quasar; CP-16533-1

Frequently Asked Questions

What are the CAS number and molecular formula of Verapamil?

CAS 52-53-9; molecular formula C27H38N2O4; molecular weight — g/mol.

What other names is Verapamil known by?

VERAPAMIL, 52-53-9, Iproveratril, Dilacoran, Verapamilo, Cardibeltin.

Is Verapamil classified as hazardous?

Hazard statements reported: H301, H311, H331.

What are the key physical properties of Verapamil?

Boiling Point: BP: 245 °C at 0.01 mm Hg; Boiling Point: 243-246 °C at 1.00E-02 mm Hg; Melting Point: < 25 °C; Solubility: 4.47 mg/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.