Tris(hydroxymethyl)aminomethane (CAS 77-86-1) — formula C4H11NO3, molecular weight 121.14; category pharmaceutical intermediates and APIs.
| CAS Number | 77-86-1 |
|---|---|
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.14 |
| Melting Point | 171-172 °C |
| Boiling Point | 219-220 °C at 10 mm Hg |
| LogP | -2.9 |
| Applications | Uses: CIR ingredient: Tromethamine, Used in chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and soluble oils), and as an absorbent for acidic gases, biological buffer, acidimetric standard, and therapeutic alkalinizing agent, [Merck Index] Used in buffer systems for the freezer storage of sperm, [REPROTOX] Used in to regulate pH in the transport of live aquatic species, cell culture media, and anti-inflammatory drugs, [EPA ChAMP: Submission], Leather Tanning and Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], In the synthesis of surface-active agents, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, so-called soluble oils. Absorbent for acidic gases. Biological buffer., Therapeutic Category: Alkalinizing agent, MEDICATION, MEDICATION (VET), Use (kg, approx.) in Germany (2009): >500, Consumption (g per capita, approx.) in Germany (2009): 0.00611, Calculated removal (%): 92.1, Use Classification: Fragrance Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Cosmetics -> Buffering, Industry Uses: Other, Processing aids not otherwise specified, Consumer Uses: Laboratory chemicals, Household Products: Information on 2 consumer products that contain Tromethamine in the following categories is provided:, • Personal Care, Methods of Manufacturing: ... Prepared by reduction of tris(hydroxymethyl)nitromethane., May be prepared by reducation or catalytic hydrogenation of the corresponding nitro compd. ... Preparation by by electrolytic reduction: McMillan, US patent 2485982 (1949 to Comm Solvents Corp), Formulations, Preparations: Tromethamine formulations: Parenteral injection 36 mg, mL (18 g) Tham, Hospira., TROMETHAMINE, NF (THAM), IS AVAIL AS 0.3 MOLAR SOLN ADJUSTED TO PH 8.6 WITH ACETIC ACID. IT IS ALSO SUPPLIED AS POWDER (THAM-E) TO BE DISSOLVED IN 1 L OF STERILE WATER. EACH L CONTAINS 300 MMOLES (36 G) OF TROMETHAMINE, 30 MMOLES OF SODIUM CHLORIDE, & 5 MMOLES OF POTASSIUM CHLORIDE., U.S. Production: 2023: 10, 000, 000 - <50, 000 lb, 2022: 10, 2021: 10, 2020: 5, 000 - <10, Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4578], 1, 3-Propanediol, 2-amino-2-(hydroxymethyl)- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Pharmaceutical and Medicine Manufacturing, Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing, All Other Chemical Product and Preparation Manufacturing, 2-amino-2-(hydroxymethyl)-: ACTIVE |
| Category | Pharmaceutical Raw Materials |
Documented applications: Uses: CIR ingredient: Tromethamine, Used in chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and soluble oils), and as an absorbent for acidic gases, biological buffer, acidimetric standard, and therapeutic alkalinizing agent, [Merck Index] Used in buffer systems for the freezer storage of sperm, [REPROTOX] Used in to regulate pH in the transport of live aquatic species, cell culture media, and anti-inflammatory drugs, [EPA ChAMP: Submission], Leather Tanning and Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], In the synthesis of surface-active agents, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, so-called soluble oils. Absorbent for acidic gases. Biological buffer., Therapeutic Category: Alkalinizing agent, MEDICATION, MEDICATION (VET), Use (kg, approx.) in Germany (2009): >500, Consumption (g per capita, approx.) in Germany (2009): 0.00611, Calculated removal (%): 92.1, Use Classification: Fragrance Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Cosmetics -> Buffering, Industry Uses: Other, Processing aids not otherwise specified, Consumer Uses: Laboratory chemicals, Household Products: Information on 2 consumer products that contain Tromethamine in the following categories is provided:, • Personal Care, Methods of Manufacturing: ... Prepared by reduction of tris(hydroxymethyl)nitromethane., May be prepared by reducation or catalytic hydrogenation of the corresponding nitro compd. ... Preparation by by electrolytic reduction: McMillan, US patent 2485982 (1949 to Comm Solvents Corp), Formulations, Preparations: Tromethamine formulations: Parenteral injection 36 mg, mL (18 g) Tham, Hospira., TROMETHAMINE, NF (THAM), IS AVAIL AS 0.3 MOLAR SOLN ADJUSTED TO PH 8.6 WITH ACETIC ACID. IT IS ALSO SUPPLIED AS POWDER (THAM-E) TO BE DISSOLVED IN 1 L OF STERILE WATER. EACH L CONTAINS 300 MMOLES (36 G) OF TROMETHAMINE, 30 MMOLES OF SODIUM CHLORIDE, & 5 MMOLES OF POTASSIUM CHLORIDE., U.S. Production: 2023: 10, 000, 000 - <50, 000 lb, 2022: 10, 2021: 10, 2020: 5, 000 - <10, Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4578], 1, 3-Propanediol, 2-amino-2-(hydroxymethyl)- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Pharmaceutical and Medicine Manufacturing, Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing, All Other Chemical Product and Preparation Manufacturing, 2-amino-2-(hydroxymethyl)-: ACTIVE.
Tris(hydroxymethyl)aminomethane is a pharmaceutical intermediate or API compound with CAS registry number 77-86-1 and molecular formula C4H11NO3 (molecular weight 121.14), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 77-86-1
Its molecular formula C4H11NO3 comprises 4 C, 11 H, 1 N, 3 O atoms.
Also known as: Tris(hydroxymethyl)aminomethane · Tris Base
Category: pharmaceutical intermediates and APIs
The CAS registry number of Tris(hydroxymethyl)aminomethane is 77-86-1.
Molecular formula C4H11NO3, molecular weight 121.14.
It is also registered under: Tris(hydroxymethyl)aminomethane, Tris Base.
Recorded applications: Uses: CIR ingredient: Tromethamine, Used in chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and soluble oils), and as an absorbent for acidic gases, biological buffer, acidimetric standard, and therapeutic alkalinizing agent, [Merck Index] Used in buffer systems for the freezer storage of sperm, [REPROTOX] Used in to regulate pH in the transport of live aquatic species, cell culture media, and anti-inflammatory drugs, [EPA ChAMP: Submission], Leather Tanning and Processing [Category: Industry], Textiles (Printing, Dyeing, or Finishing) [Category: Industry], In the synthesis of surface-active agents, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, so-called soluble oils. Absorbent for acidic gases. Biological buffer., Therapeutic Category: Alkalinizing agent, MEDICATION, MEDICATION (VET), Use (kg, approx.) in Germany (2009): >500, Consumption (g per capita, approx.) in Germany (2009): 0.00611, Calculated removal (%): 92.1, Use Classification: Fragrance Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Cosmetics -> Buffering, Industry Uses: Other, Processing aids not otherwise specified, Consumer Uses: Laboratory chemicals, Household Products: Information on 2 consumer products that contain Tromethamine in the following categories is provided:, • Personal Care, Methods of Manufacturing: ... Prepared by reduction of tris(hydroxymethyl)nitromethane., May be prepared by reducation or catalytic hydrogenation of the corresponding nitro compd. ... Preparation by by electrolytic reduction: McMillan, US patent 2485982 (1949 to Comm Solvents Corp), Formulations, Preparations: Tromethamine formulations: Parenteral injection 36 mg, mL (18 g) Tham, Hospira., TROMETHAMINE, NF (THAM), IS AVAIL AS 0.3 MOLAR SOLN ADJUSTED TO PH 8.6 WITH ACETIC ACID. IT IS ALSO SUPPLIED AS POWDER (THAM-E) TO BE DISSOLVED IN 1 L OF STERILE WATER. EACH L CONTAINS 300 MMOLES (36 G) OF TROMETHAMINE, 30 MMOLES OF SODIUM CHLORIDE, & 5 MMOLES OF POTASSIUM CHLORIDE., U.S. Production: 2023: 10, 000, 000 - <50, 000 lb, 2022: 10, 2021: 10, 2020: 5, 000 - <10, Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#4578], 1, 3-Propanediol, 2-amino-2-(hydroxymethyl)- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Pharmaceutical and Medicine Manufacturing, Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing, All Other Chemical Product and Preparation Manufacturing, 2-amino-2-(hydroxymethyl)-: ACTIVE.
Category: Pharmaceutical Raw Materials.
Independent reference data for Tris(hydroxymethyl)aminomethane (CAS 77-86-1), compiled from public chemistry databases.
| CAS 号 | 77-86-1 |
|---|---|
| PubChem CID | 6503 |
| 分子式 | C4H11NO3 |
| IUPAC 名称 | 2-amino-2-(hydroxymethyl)propane-1,3-diol |
| UNII（FDA） | 023C2WHX2V |
| Molecular Weight | 121.14 |
|---|---|
| XLogP3 | -2.9 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 121.07389321 |
| Monoisotopic Mass | 121.07389321 |
| Topological Polar Surface Area | 86.7 |
| Heavy Atom Count | 8 |
| Boiling Point | 219-220 °C at 10 mm Hg |
|---|---|
| Melting Point | 171-172 °C |
| Solubility | In water, 5.50X10+5 mg/L at 25 °C |
| Vapor Pressure | 0.000022 [mmHg] |
| Ionization Efficiency | 2.41 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Ionization Efficiency | DOI:10.1007/s13361-016-1563-2 |
| Dissociation Constants | 8.08 |
| Dissociation Constants | pKa = 8.07 |
氨丁三醇；氨丁三醇； 77-86-1；三(羟甲基)氨基甲烷；谭；三胺； 2-氨基-2-(羟甲基)-1,3-丙二醇； Tris缓冲液；氨丁三醇； Tris碱基；三氨基酚；行为规范；塔拉特罗； Tutofusin tris; Tris-不育；阿德克斯塔姆
| 法规与食品接触 | CIR / INCI: Cosmetic ingredients (Tromethamine) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS 通报统计 | 19.7% (235 / 1192) |
| GHS 通报统计 | 19.7% (235 / 1192) |
|---|---|
| 已通报的危害声明 | H315 (80.2%), H319 (80.3%), H335 (70.8%) |
三羟甲基氨基甲烷 · CAS 77-86-1 · C4H11NO3. UNII 023C2WHX2V. Boiling Point: 219-220 °C at 10 mm Hg; Melting Point: 171-172 °C; Solubility: In water, 5.50X10+5 mg/L at 25 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.