Tris(hydroxymethyl)aminomethane (CAS 77-86-1) — formula C4H11NO3, molecular weight 121.14; category pharmaceutical intermediates and APIs.
Tris(hydroxymethyl)aminomethane (CAS 77-86-1) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C4H11NO3 comprises 4 C, 11 H, 1 N, 3 O atoms. Its molecular weight is about 121.14. Reported physicochemical data: melting point around 171-172 °C, boiling point around 219-220 °C at 10 mm Hg, LogP about -2.9. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 77-86-1 |
|---|---|
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.14 |
| Melting Point | 171-172 °C |
| Boiling Point | 219-220 °C at 10 mm Hg |
| LogP | -2.9 |
| Applications | CIR ingredient: Tromethamine, chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions |
| Category | Pharmaceutical Intermediates & APIs|Pharmaceutical Raw Materials |
Documented applications: CIR ingredient: Tromethamine, chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions.
Tris(hydroxymethyl)aminomethane is a pharmaceutical intermediate or API compound with CAS registry number 77-86-1 and molecular formula C4H11NO3 (molecular weight 121.14), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 77-86-1
Its molecular formula C4H11NO3 comprises 4 C, 11 H, 1 N, 3 O atoms.
Also known as: Tris(hydroxymethyl)aminomethane · Tris Base
Category: pharmaceutical intermediates and APIs / pharmaceutical intermediates and APIs
The CAS registry number of Tris(hydroxymethyl)aminomethane is 77-86-1.
Molecular formula C4H11NO3, molecular weight 121.14.
It is also registered under: Tris(hydroxymethyl)aminomethane, Tris Base.
Recorded applications: CIR ingredient: Tromethamine, chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions.
Category: Pharmaceutical Intermediates & APIs / Pharmaceutical Raw Materials.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for Tris(hydroxymethyl)aminomethane (CAS 77-86-1), compiled from public chemistry databases.
| CAS Number | 77-86-1 |
|---|---|
| PubChem CID | 6503 |
| Molecular Formula | C4H11NO3 |
| IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol |
| UNII (FDA) | 023C2WHX2V |
| Molecular Weight | 121.14 |
|---|---|
| XLogP3 | -2.9 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 121.07389321 |
| Monoisotopic Mass | 121.07389321 |
| Topological Polar Surface Area | 86.7 |
| Heavy Atom Count | 8 |
| Boiling Point | 219-220 °C at 10 mm Hg |
|---|---|
| Melting Point | 171-172 °C |
| Solubility | In water, 5.50X10+5 mg/L at 25 °C |
| Vapor Pressure | 0.000022 [mmHg] |
| Ionization Efficiency | 2.41 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Ionization Efficiency | DOI:10.1007/s13361-016-1563-2 |
| Dissociation Constants | 8.08 |
| Dissociation Constants | pKa = 8.07 |
| Regulatory & food contact | CIR / INCI: Cosmetic ingredients (Tromethamine) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS notifications | 19.7% (235 / 1192) |
| GHS notifications | 19.7% (235 / 1192) |
|---|---|
| Notified hazard statements | H315 (80.2%), H319 (80.3%), H335 (70.8%) |
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.