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Description

Tripelennamine · CAS 91-81-6 · C16H21N3. UNII 3C5ORO99TY. Boiling Point: 365 to 374 °F at 1.7 mmHg (NTP, 1992); Boiling Point: 19.3-20.5 °C @ 5 mm Hg; Solubility: 587.

Identification

CAS Registry Number	91-81-6
PubChem CID	5587
Molecular formula	C16H21N3
IUPAC name	N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
UNII (FDA)	3C5ORO99TY

Computed Descriptors

Molecular Weight	255.36
XLogP3	3.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	255.173547683
Monoisotopic Mass	255.173547683
Topological Polar Surface Area	19.4
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Boiling Point	365 to 374 °F at 1.7 mmHg (NTP, 1992)
Boiling Point	19.3-20.5 °C @ 5 mm Hg
Solubility	587
Solubility	2.84e+00 g/L
LogP	3.3
LogP	2.65
Dissociation Constants	PKB= 4.93

Physical description & handling notes

• Tripelenamine is an oily liquid with an amine odor. (NTP, 1992)
• Solid
• YELLOW OIL
• AMINE ODOR
• Very soluble (NTP, 1992)
• 1 G DISSOLVES IN: 0.77 ML WATER, 6 ML ALCOHOL, 6 ML CHLOROFORM, ABOUT 350 ML ACETONE; PRACTICALLY INSOL IN BENZENE, ETHER, ETHYL ACETATE /HYDROCHLORIDE/

GHS Hazard Classification

Reported hazard statements	H302 (100%), H318 (100%), H331 (100%), H361 (100%), H373 (100%), H411 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• REACTION OF O-AMINOPYRIDINE AND BETA-DIMETHYLAMINOETHYL CHLORIDE IN THE PRESENCE OF SODAMIDE FOLLOWED BY CONDENSATION WITH BENZYL BROMIDE
• ...BY SODAMIDE CONDENSATION OF N,N-DIMETHYLAMINOETHYL-2-AMINOPYRIDINE WITH DIMETHYLAMINOETHYL CHLORIDE.
• TRIPELENNAMINE IS REACTED WITH EQUIMOLAR PORTION OF CITRIC ACID IN SUITABLE SOLVENT WHICH MAY THEN BE REMOVED BY EVAPORATION. /CITRATE/
• TRIPELENNAMINE MAY BE PREPARED AS FOLLOWS: O-AMINOPYRIDINE, PREPARED BY ACTION OF SODAMIDE ON PYRIDINE, IS REACTED WITH BETA-DIMETHYLAMINOETHYL CHLORIDE IN PRESENCE OF SODAMIDE, & RESULTING 2-[2-(DIMETHYLAMINO)ETHYLAMINO]PYRIDINE IS CONDENSED WITH BENZYLBROMIDE IN PRESENCE OF SODAMIDE. /HYDROCHLORIDE/

Synonyms

tripelennamine; 91-81-6; Pyrinamine base; Tripelennamin; Benzoxale; Resistamine; Cizaron; Tonaril; Piribenzil; Tripelennamina; Pyribenzamin; Tripelenamina; Tripelennaminum; N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine; 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-; 2-(Benzyl(2-dimethylaminoethyl)amino)pyridine

Frequently Asked Questions

What are the CAS number and molecular formula of Tripelennamine?

CAS 91-81-6; molecular formula C16H21N3; molecular weight — g/mol.

What other names is Tripelennamine known by?

tripelennamine, 91-81-6, Pyrinamine base, Tripelennamin, Benzoxale, Resistamine.

Is Tripelennamine classified as hazardous?

Hazard statements reported: H302, H318, H331, H361, H373.

What are the key physical properties of Tripelennamine?

Boiling Point: 365 to 374 °F at 1.7 mmHg (NTP, 1992); Boiling Point: 19.3-20.5 °C @ 5 mm Hg; Solubility: 587; Solubility: 2.84e+00 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.