Trihexylphenedyl（CAS 144-11-6）：分子式 C20H31NO、分子量 301.5；类别 有机化学品。
| CAS号 | 144-11-6 |
|---|---|
| 分子式 | C20H31NO |
| 分子量 | 301.5 |
| 熔点 | 115 |
| LogP | 4.49 |
| 应用领域 | Uses: Synthetic antispasmodic ... adjunct in the treatment of all forms of parksinonism (postencephalitic、arteriosclerotic、and idiopathic)、Trihexylphenidyl hydrochloride、THERAP CAT: Antiparkinsonian、MEDICATION、Use (kg、approx.) in Germany (2009): >10、Use (kg) in France (2004): 257、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in France (2004): 0.00425、Calculated removal (%): 72.7、Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.、Use Classification: Pharmaceuticals、Methods of Manufacturing: ACETOPHENONE & PIPERIDINE ARE CAUSED TO UNDERGO MANNICH CONDENSATION WITH FORMALDEHYDE... 3-PIPERIDINOPROPIOPHENONE THUS PRODUCED IS ISOLATED & SUBJECTED TO TYPICAL GRIGNARD REACTION WITH CYCLOHEXYLMAGNESIUM CHLORIDE TO YIELD...TRIHEXYPHENIDYL BASE. HYDROCHLORIDE IS...PREPD BY...PPTN WITH...HYDROGEN CHLORIDE.、HCL、Adamson、Wilkinson、US 2682543 (1954 to Burroughs Wellcome)、Denton、US 2716121 (1955 to American Cyanamide).、Trihexyphenidyl hydrochloride、Impurities: 1-phenyl-3-(piperidine-1-yl)propan-1-one、Formulations、Preparations: Trade Names. Artane (Lederle)、Bentex (Steinhard)、Broflex (Bio-Med)、Pargitan (KabiVitrum)、Parkinane (Lederle)、Triphenidone (Toho).、Oral: Elixir: 2 mg、5 mL Trihexyphenidyl Hydrochloride Elixir (Mikart)、(Pharmaceutical Associates)、(Pharmaceutical Ventures). Tablets: 2 mg Trihexyphenidyl Hydrochloride Tablets (URL)、(Vintage)、(Watson)、(West-Ward)、5 mg Trihexyphenidyl Hydrochloride Tablets (URL)、(West-Ward).、Trihexypheridyl hydrochloride、General Manufacturing Information: TRIHEXYPHENIDYL MAY BE COMBINED WITH OTHER ANTIPARKINSONIAN DRUGS. |
| 类别 | Organic Chemicals |
登记用途：Uses: Synthetic antispasmodic ... adjunct in the treatment of all forms of parksinonism (postencephalitic、arteriosclerotic、and idiopathic)、Trihexylphenidyl hydrochloride、THERAP CAT: Antiparkinsonian、MEDICATION、Use (kg、approx.) in Germany (2009): >10、Use (kg) in France (2004): 257、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in France (2004): 0.00425、Calculated removal (%): 72.7、Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.、Use Classification: Pharmaceuticals、Methods of Manufacturing: ACETOPHENONE & PIPERIDINE ARE CAUSED TO UNDERGO MANNICH CONDENSATION WITH FORMALDEHYDE... 3-PIPERIDINOPROPIOPHENONE THUS PRODUCED IS ISOLATED & SUBJECTED TO TYPICAL GRIGNARD REACTION WITH CYCLOHEXYLMAGNESIUM CHLORIDE TO YIELD...TRIHEXYPHENIDYL BASE. HYDROCHLORIDE IS...PREPD BY...PPTN WITH...HYDROGEN CHLORIDE.、HCL、Adamson、Wilkinson、US 2682543 (1954 to Burroughs Wellcome)、Denton、US 2716121 (1955 to American Cyanamide).、Trihexyphenidyl hydrochloride、Impurities: 1-phenyl-3-(piperidine-1-yl)propan-1-one、Formulations、Preparations: Trade Names. Artane (Lederle)、Bentex (Steinhard)、Broflex (Bio-Med)、Pargitan (KabiVitrum)、Parkinane (Lederle)、Triphenidone (Toho).、Oral: Elixir: 2 mg、5 mL Trihexyphenidyl Hydrochloride Elixir (Mikart)、(Pharmaceutical Associates)、(Pharmaceutical Ventures). Tablets: 2 mg Trihexyphenidyl Hydrochloride Tablets (URL)、(Vintage)、(Watson)、(West-Ward)、5 mg Trihexyphenidyl Hydrochloride Tablets (URL)、(West-Ward).、Trihexypheridyl hydrochloride、General Manufacturing Information: TRIHEXYPHENIDYL MAY BE COMBINED WITH OTHER ANTIPARKINSONIAN DRUGS.。
Trihexylphenedyl 是一种以碳骨架为基础的有机化合物，登记 CAS 号为 144-11-6，分子式 C20H31NO（分子量 301.5），归属于有机化学品大类化工原料。
登记 CAS 号：144-11-6
其分子式 C20H31NO 由 20 个碳、31 个氢、1 个氮、1 个氧 组成。
别名/同义词：Trihexylphenedyl
所属分类：有机化学品
Trihexylphenedyl 的 CAS 登记号为 144-11-6。
分子式 C20H31NO，分子量 301.5。
别名/同义词：Trihexylphenedyl。
登记用途：Uses: Synthetic antispasmodic ... adjunct in the treatment of all forms of parksinonism (postencephalitic、arteriosclerotic、and idiopathic)、Trihexylphenidyl hydrochloride、THERAP CAT: Antiparkinsonian、MEDICATION、Use (kg、approx.) in Germany (2009): >10、Use (kg) in France (2004): 257、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in France (2004): 0.00425、Calculated removal (%): 72.7、Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.、Use Classification: Pharmaceuticals、Methods of Manufacturing: ACETOPHENONE & PIPERIDINE ARE CAUSED TO UNDERGO MANNICH CONDENSATION WITH FORMALDEHYDE... 3-PIPERIDINOPROPIOPHENONE THUS PRODUCED IS ISOLATED & SUBJECTED TO TYPICAL GRIGNARD REACTION WITH CYCLOHEXYLMAGNESIUM CHLORIDE TO YIELD...TRIHEXYPHENIDYL BASE. HYDROCHLORIDE IS...PREPD BY...PPTN WITH...HYDROGEN CHLORIDE.、HCL、Adamson、Wilkinson、US 2682543 (1954 to Burroughs Wellcome)、Denton、US 2716121 (1955 to American Cyanamide).、Trihexyphenidyl hydrochloride、Impurities: 1-phenyl-3-(piperidine-1-yl)propan-1-one、Formulations、Preparations: Trade Names. Artane (Lederle)、Bentex (Steinhard)、Broflex (Bio-Med)、Pargitan (KabiVitrum)、Parkinane (Lederle)、Triphenidone (Toho).、Oral: Elixir: 2 mg、5 mL Trihexyphenidyl Hydrochloride Elixir (Mikart)、(Pharmaceutical Associates)、(Pharmaceutical Ventures). Tablets: 2 mg Trihexyphenidyl Hydrochloride Tablets (URL)、(Vintage)、(Watson)、(West-Ward)、5 mg Trihexyphenidyl Hydrochloride Tablets (URL)、(West-Ward).、Trihexypheridyl hydrochloride、General Manufacturing Information: TRIHEXYPHENIDYL MAY BE COMBINED WITH OTHER ANTIPARKINSONIAN DRUGS.。
所属分类：Organic Chemicals。
Trihexylphenedyl（CAS 144-11-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 144-11-6 |
|---|---|
| PubChem CID | 5572 |
| Molecular formula | C20H31NO |
| IUPAC name | 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol |
| UNII (FDA) | 6RC5V8B7PO |
| Molecular Weight | 301.5 |
|---|---|
| XLogP3 | 4.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 301.240564612 |
| Monoisotopic Mass | 301.240564612 |
| Topological Polar Surface Area | 23.5 |
| Heavy Atom Count | 22 |
| Melting Point | 115 |
|---|---|
| Melting Point | 114 °C |
| Melting Point | 258.5 °C |
| Solubility | 3.14e-03 g/L |
| LogP | 4.49 |
| LogP | log Kow = 4.49 |
| LogP | 4.5 |
| Dissociation Constants | 8.7 |
| Other Experimental Properties | Free base mp 112-113 °C. /L-form/ |
trihexyphenidyl; Benzhexol; 144-11-6; Triphenidyl; Trihexyphenidyle; Benzhexolum; Trihexifenidilo; Trihexyphenidylum; Apo-Trihex; 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; 6RC5V8B7PO; NSC-12268; DTXSID4023705; 5-20-02-00231 (Beilstein Handbook Reference); Triesifenidile
| Reported hazard statements | H301 (100%) |
|---|
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Trihexylphenedyl · CAS 144-11-6 · C20H31NO. UNII 6RC5V8B7PO. Melting Point: 115; Melting Point: 114 °C; Melting Point: 258.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Trihexylphenedyl