去炎松（CAS 124-94-7）：分子式 C21H27FO6、分子量 394.4。
| CAS号 | 124-94-7 |
|---|---|
| 分子式 | C21H27FO6 |
| 分子量 | 394.4 |
| 熔点 | 270 |
| LogP | log Kow = 1.16 |
| 应用领域 | Uses: Glucocorticoid used for systemic or local anti-inflammatory activity、Treatment of inflammation and related disorders in dogs and cats、and management and treatment of acute arthritis and allergic and dermatologic disorders in dogs and cats. Treatment of inflammation and related disorders in horses.、Acetonide、Vetalog Parenteral Veterinary、Topically: Use either ointment in cats for anti-inflammatory、antipruritic、antifungal、and antibacterial treatment of superficial bacterial infections、and for dermatologic disorders characterized by inflammation and dry or exudative dermatitis、particularly associated with bacterial or candidal (Candida albicans) infections.、Panolog Ointment、The drug is recommended ... for topical treatment of summer eczema.、Vetalog Cream、For more Uses (Complete) data for TRIAMCINOLONE (8 total)、please visit the HSDB record page.、Use (kg) in USA (2002): 2300、Consumption (g per capita) in the USA (2002): 0.00815、Calculated removal (%): 45.6、For the treatment of perennial and seasonal allergic rhinitis.、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Bernstein et al、Allen et al、US 2789118、US 3021347 (1957、1962、both to American Cyanamid).、Triamcinolone is prepared commercially via a method developed by Bernstein and coworkers. By starting with cortisol 21-acetate、reaction with ethylene glycol gives the 3、20-bisethylene ketal. The 11b- and 17a-hydroxyl groups of this compound are then dehydrated with thionyl chloride in pyridine、followed by alkaline saponification of the 21-acetate group、acid deketalization of the cyclic acetal groups at positions 3 and 20、and reacetylation of the 21-hydroxyl group ... Selective hydroxylation of the double bond at position 16 with osmium tetroxide in pyridine - benzene ... The 9、11-double bond of this compound is converted to a 9a-fluoro-11b-hydroxyl group ... Triamcinolone is obtained after alkaline saponification of the 21-acetate group and microbiological introduction of the D1 double bond with Corynebacterium simplex.、Impurities: 9-fluoro-11beta、17-dihydroxy-3、20-dioxopregna-1、4-diene-16alpha、21-diyl diacetate (triamcinolone 16、21-diacetate)、9-fluoro-11beta、16alpha、17-trihydroxy-3、4-diene-21-diyl acetate (triamcinolone 21-acetate)、17、21-tetrahydroxypregn-4-ene-3、20-dione (pretriamcinolone)、Formulations、Preparations: Oral: Tablets: 4 mg Aristocort (scored)、(Astellas).、Parenteral: Injectable suspension: 5 mg、mL Aristospan Intralesional (with benzyl alcohol)、(Sabex)、20 mg、mL Aristospan Intra-articular (with benzyl alcohol)、(Sabex).、Triamcinolone hexacetonide (microcrystalline)、Oral Inhalation: Aerosol 100 ug、metered spray Azmacort Oral Inhaler (with dehydrated alcohol 1% w、w and dichlorodifluoromethane propellant)、(Kos).、Triamcinolone acetonide (microcrystalline)、Parenteral: Injectable suspension: 3 mg、mL Tac (with benzyl alcohol)、(Parnell)、10 mg、mL Kenalog (with benzyl alcohol)、(Bristol-Myers Squibb)、40 mg、(Bristol-Myers Squibb).、Triamcinolone acetonide、For more Formulations、Preparations (Complete) data for TRIAMCINOLONE (6 total)、General Manufacturing Information: Marketed as its acetonide (76-25-5) in Vetalog cream、oral powder、tablets、and parenteral solution. |
登记用途：Uses: Glucocorticoid used for systemic or local anti-inflammatory activity、Treatment of inflammation and related disorders in dogs and cats、and management and treatment of acute arthritis and allergic and dermatologic disorders in dogs and cats. Treatment of inflammation and related disorders in horses.、Acetonide、Vetalog Parenteral Veterinary、Topically: Use either ointment in cats for anti-inflammatory、antipruritic、antifungal、and antibacterial treatment of superficial bacterial infections、and for dermatologic disorders characterized by inflammation and dry or exudative dermatitis、particularly associated with bacterial or candidal (Candida albicans) infections.、Panolog Ointment、The drug is recommended ... for topical treatment of summer eczema.、Vetalog Cream、For more Uses (Complete) data for TRIAMCINOLONE (8 total)、please visit the HSDB record page.、Use (kg) in USA (2002): 2300、Consumption (g per capita) in the USA (2002): 0.00815、Calculated removal (%): 45.6、For the treatment of perennial and seasonal allergic rhinitis.、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Bernstein et al、Allen et al、US 2789118、US 3021347 (1957、1962、both to American Cyanamid).、Triamcinolone is prepared commercially via a method developed by Bernstein and coworkers. By starting with cortisol 21-acetate、reaction with ethylene glycol gives the 3、20-bisethylene ketal. The 11b- and 17a-hydroxyl groups of this compound are then dehydrated with thionyl chloride in pyridine、followed by alkaline saponification of the 21-acetate group、acid deketalization of the cyclic acetal groups at positions 3 and 20、and reacetylation of the 21-hydroxyl group ... Selective hydroxylation of the double bond at position 16 with osmium tetroxide in pyridine - benzene ... The 9、11-double bond of this compound is converted to a 9a-fluoro-11b-hydroxyl group ... Triamcinolone is obtained after alkaline saponification of the 21-acetate group and microbiological introduction of the D1 double bond with Corynebacterium simplex.、Impurities: 9-fluoro-11beta、17-dihydroxy-3、20-dioxopregna-1、4-diene-16alpha、21-diyl diacetate (triamcinolone 16、21-diacetate)、9-fluoro-11beta、16alpha、17-trihydroxy-3、4-diene-21-diyl acetate (triamcinolone 21-acetate)、17、21-tetrahydroxypregn-4-ene-3、20-dione (pretriamcinolone)、Formulations、Preparations: Oral: Tablets: 4 mg Aristocort (scored)、(Astellas).、Parenteral: Injectable suspension: 5 mg、mL Aristospan Intralesional (with benzyl alcohol)、(Sabex)、20 mg、mL Aristospan Intra-articular (with benzyl alcohol)、(Sabex).、Triamcinolone hexacetonide (microcrystalline)、Oral Inhalation: Aerosol 100 ug、metered spray Azmacort Oral Inhaler (with dehydrated alcohol 1% w、w and dichlorodifluoromethane propellant)、(Kos).、Triamcinolone acetonide (microcrystalline)、Parenteral: Injectable suspension: 3 mg、mL Tac (with benzyl alcohol)、(Parnell)、10 mg、mL Kenalog (with benzyl alcohol)、(Bristol-Myers Squibb)、40 mg、(Bristol-Myers Squibb).、Triamcinolone acetonide、For more Formulations、Preparations (Complete) data for TRIAMCINOLONE (6 total)、General Manufacturing Information: Marketed as its acetonide (76-25-5) in Vetalog cream、oral powder、tablets、and parenteral solution.。
去炎松 是一种化工化合物，登记 CAS 号为 124-94-7，分子式 C21H27FO6（分子量 394.4）。
登记 CAS 号：124-94-7
其分子式 C21H27FO6 由 21 个碳、27 个氢、1 个氟、6 个氧 组成。
别名/同义词：去炎松 · triamcinolone
去炎松 的 CAS 登记号为 124-94-7。
分子式 C21H27FO6，分子量 394.4。
别名/同义词：去炎松、triamcinolone。
登记用途：Uses: Glucocorticoid used for systemic or local anti-inflammatory activity、Treatment of inflammation and related disorders in dogs and cats、and management and treatment of acute arthritis and allergic and dermatologic disorders in dogs and cats. Treatment of inflammation and related disorders in horses.、Acetonide、Vetalog Parenteral Veterinary、Topically: Use either ointment in cats for anti-inflammatory、antipruritic、antifungal、and antibacterial treatment of superficial bacterial infections、and for dermatologic disorders characterized by inflammation and dry or exudative dermatitis、particularly associated with bacterial or candidal (Candida albicans) infections.、Panolog Ointment、The drug is recommended ... for topical treatment of summer eczema.、Vetalog Cream、For more Uses (Complete) data for TRIAMCINOLONE (8 total)、please visit the HSDB record page.、Use (kg) in USA (2002): 2300、Consumption (g per capita) in the USA (2002): 0.00815、Calculated removal (%): 45.6、For the treatment of perennial and seasonal allergic rhinitis.、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Bernstein et al、Allen et al、US 2789118、US 3021347 (1957、1962、both to American Cyanamid).、Triamcinolone is prepared commercially via a method developed by Bernstein and coworkers. By starting with cortisol 21-acetate、reaction with ethylene glycol gives the 3、20-bisethylene ketal. The 11b- and 17a-hydroxyl groups of this compound are then dehydrated with thionyl chloride in pyridine、followed by alkaline saponification of the 21-acetate group、acid deketalization of the cyclic acetal groups at positions 3 and 20、and reacetylation of the 21-hydroxyl group ... Selective hydroxylation of the double bond at position 16 with osmium tetroxide in pyridine - benzene ... The 9、11-double bond of this compound is converted to a 9a-fluoro-11b-hydroxyl group ... Triamcinolone is obtained after alkaline saponification of the 21-acetate group and microbiological introduction of the D1 double bond with Corynebacterium simplex.、Impurities: 9-fluoro-11beta、17-dihydroxy-3、20-dioxopregna-1、4-diene-16alpha、21-diyl diacetate (triamcinolone 16、21-diacetate)、9-fluoro-11beta、16alpha、17-trihydroxy-3、4-diene-21-diyl acetate (triamcinolone 21-acetate)、17、21-tetrahydroxypregn-4-ene-3、20-dione (pretriamcinolone)、Formulations、Preparations: Oral: Tablets: 4 mg Aristocort (scored)、(Astellas).、Parenteral: Injectable suspension: 5 mg、mL Aristospan Intralesional (with benzyl alcohol)、(Sabex)、20 mg、mL Aristospan Intra-articular (with benzyl alcohol)、(Sabex).、Triamcinolone hexacetonide (microcrystalline)、Oral Inhalation: Aerosol 100 ug、metered spray Azmacort Oral Inhaler (with dehydrated alcohol 1% w、w and dichlorodifluoromethane propellant)、(Kos).、Triamcinolone acetonide (microcrystalline)、Parenteral: Injectable suspension: 3 mg、mL Tac (with benzyl alcohol)、(Parnell)、10 mg、mL Kenalog (with benzyl alcohol)、(Bristol-Myers Squibb)、40 mg、(Bristol-Myers Squibb).、Triamcinolone acetonide、For more Formulations、Preparations (Complete) data for TRIAMCINOLONE (6 total)、General Manufacturing Information: Marketed as its acetonide (76-25-5) in Vetalog cream、oral powder、tablets、and parenteral solution.。
去炎松（CAS 124-94-7）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 124-94-7 |
|---|---|
| PubChem CID | 31307 |
| Molecular formula | C21H27FO6 |
| IUPAC name | (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| UNII (FDA) | 1ZK20VI6TY |
| Molecular Weight | 394.4 |
|---|---|
| XLogP3 | 1.2 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 394.17916674 |
| Monoisotopic Mass | 394.17916674 |
| Topological Polar Surface Area | 115 |
| Heavy Atom Count | 28 |
| Melting Point | 270 |
|---|---|
| Melting Point | 269-271 °C |
| Melting Point | 274 - 278 °C |
| Solubility | In water, 80 mg/L at 25 °C |
| Solubility | 8.47e-01 g/L |
| Vapor Pressure | 7.20X10-15 mm Hg at 25 °C |
| LogP | log Kow = 1.16 |
| LogP | 0.2 |
triamcinolone; 124-94-7; Fluoxyprednisolone; Kenacort; Rodinolone; Volon; Triamcinolon; Delphicort; Ledercort; Tricortale; Celeste; Omcilon; Triamcinolona; Triamcinolonum; Fluoxiprednisolone; Tiamcinolonum
| Reported hazard statements | H351 (63.3%), H361 (31.7%) |
|---|
H351 (63.3%): Suspected of causing cancer [Warning Carcinogenicity]
H361 (31.7%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
triamcinolone · CAS 124-94-7 · C21H27FO6. UNII 1ZK20VI6TY. Melting Point: 270; Melting Point: 269-271 °C; Melting Point: 274 - 278 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: triamcinolone