Tretinoin (CAS 302-79-4) — formula C20H28O2, molecular weight 300.4.
| CAS Number | 302-79-4 |
|---|---|
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.4 |
| Melting Point | 354 to 360 °F (NTP, 1992) |
| LogP | 6.3 |
| Applications | Uses: Antineoplastic Agents Keratolytic Agents, MEDICATION, Synthetic Polymer MALDI Matrix Compounds, Use (kg, approx.) in Germany (2009): >10, Use (kg) in USA (2002): 364, Consumption (g per capita, approx.) in Germany (2009): 0.000122, Consumption (g per capita) in the USA (2002): 0.00129, Calculated removal (%): 98.9, For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.), For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage., Methods of Manufacturing: By oxidation of vitamin A aldehyde which may be obtained by oxidation of vitamin A., R. Marbet, German patent 2061507, United States of America patent 3746730 (1971, 1973 both to Hoffmann-La Roche)., Formulations, Preparations: Oral: Capsules 10 mg, Vesanold (Roche), Table: Tretinoin (Topical) Preparations [Table#3901], General Manufacturing Information: Retinoic acid: ACTIVE |
Documented applications: Uses: Antineoplastic Agents Keratolytic Agents, MEDICATION, Synthetic Polymer MALDI Matrix Compounds, Use (kg, approx.) in Germany (2009): >10, Use (kg) in USA (2002): 364, Consumption (g per capita, approx.) in Germany (2009): 0.000122, Consumption (g per capita) in the USA (2002): 0.00129, Calculated removal (%): 98.9, For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.), For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage., Methods of Manufacturing: By oxidation of vitamin A aldehyde which may be obtained by oxidation of vitamin A., R. Marbet, German patent 2061507, United States of America patent 3746730 (1971, 1973 both to Hoffmann-La Roche)., Formulations, Preparations: Oral: Capsules 10 mg, Vesanold (Roche), Table: Tretinoin (Topical) Preparations [Table#3901], General Manufacturing Information: Retinoic acid: ACTIVE.
Tretinoin is a chemical compound with CAS registry number 302-79-4 and molecular formula C20H28O2 (molecular weight 300.4).
CAS number: 302-79-4
Its molecular formula C20H28O2 comprises 20 C, 28 H, 2 O atoms.
Also known as: Tretinoin · 维A酸
The CAS registry number of Tretinoin is 302-79-4.
Molecular formula C20H28O2, molecular weight 300.4.
It is also registered under: Tretinoin, 维A酸.
Recorded applications: Uses: Antineoplastic Agents Keratolytic Agents, MEDICATION, Synthetic Polymer MALDI Matrix Compounds, Use (kg, approx.) in Germany (2009): >10, Use (kg) in USA (2002): 364, Consumption (g per capita, approx.) in Germany (2009): 0.000122, Consumption (g per capita) in the USA (2002): 0.00129, Calculated removal (%): 98.9, For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.), For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage., Methods of Manufacturing: By oxidation of vitamin A aldehyde which may be obtained by oxidation of vitamin A., R. Marbet, German patent 2061507, United States of America patent 3746730 (1971, 1973 both to Hoffmann-La Roche)., Formulations, Preparations: Oral: Capsules 10 mg, Vesanold (Roche), Table: Tretinoin (Topical) Preparations [Table#3901], General Manufacturing Information: Retinoic acid: ACTIVE.
Independent reference data for Tretinoin (CAS 302-79-4), compiled from public chemistry databases.
| CAS Registry Number | 302-79-4 |
|---|---|
| PubChem CID | 444795 |
| Molecular formula | C20H28O2 |
| IUPAC name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid |
| UNII (FDA) | 5688UTC01R |
| Molecular Weight | 300.4 |
|---|---|
| XLogP3 | 6.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 300.208930132 |
| Monoisotopic Mass | 300.208930132 |
| Topological Polar Surface Area | 37.3 |
| Heavy Atom Count | 22 |
| Melting Point | 354 to 360 °F (NTP, 1992) |
|---|---|
| Melting Point | 178-184 |
| Melting Point | 180-182 °C |
| Melting Point | 181 °C |
| LogP | 6.3 |
| LogP | log Kow = 6.30 |
| LogP | 6.30 |
| Collision Cross Section | 182.1 Ų [M+Na]+ |
Retinoic acid; tretinoin; 302-79-4; all-trans-Retinoic acid; Vitamin A acid; trans-Retinoic acid; ATRA; Aberel; Eudyna; Dermairol; Renova; all-trans-Vitamin A acid; Cordes vas; Retin A; Tretin M; all-trans-Tretinoin
| Reported hazard statements | H302 (29.8%), H315 (73.4%), H319 (16.5%), H335 (14.9%), H360 (72.9%), H400 (59%), H410 (58%), H411 (16%) |
|---|
H302 (29.8%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (73.4%): Causes skin irritation [Warning Skin corrosion/irritation]
Tretinoin · CAS 302-79-4 · C20H28O2. UNII 5688UTC01R. Melting Point: 354 to 360 °F (NTP, 1992); Melting Point: 178-184; Melting Point: 180-182 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 维A酸