妥拉磺酰胺（CAS 1156-19-0）：分子式 C14H21N3O3S、分子量 311.40。
| CAS号 | 1156-19-0 |
|---|---|
| 分子式 | C14H21N3O3S |
| 分子量 | 311.40 |
| 熔点 | 170-173 °C |
| LogP | 2.69 |
| 应用领域 | Uses: Therap cat: Antidiabetic、An orally effective hypoglycemic drug.、For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.、Methods of Manufacturing: Prepn: Wright、Willette、J Med Pharm Chem 5、815 (1962)、Wright、British patent 887、886 (1962 to Upjohn).、METHYL P-TOLYLSULFONYLCARBAMATE IS CAUSED TO UNDERGO AMMONOLYSIS TYPE OF REACTION WITH 1-AMINOHEXAMETHYLENEIMINE、US PATENT 3、063、903.、Formulations、Preparations: ... usually administered in a daily dose of 100 to 250 mg、while 750 to 1000 mg is maximal. |
登记用途：Uses: Therap cat: Antidiabetic、An orally effective hypoglycemic drug.、For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.、Methods of Manufacturing: Prepn: Wright、Willette、J Med Pharm Chem 5、815 (1962)、Wright、British patent 887、886 (1962 to Upjohn).、METHYL P-TOLYLSULFONYLCARBAMATE IS CAUSED TO UNDERGO AMMONOLYSIS TYPE OF REACTION WITH 1-AMINOHEXAMETHYLENEIMINE、US PATENT 3、063、903.、Formulations、Preparations: ... usually administered in a daily dose of 100 to 250 mg、while 750 to 1000 mg is maximal.。
妥拉磺酰胺 是一种化工化合物，登记 CAS 号为 1156-19-0，分子式 C14H21N3O3S（分子量 311.40）。
登记 CAS 号：1156-19-0
其分子式 C14H21N3O3S 由 14 个碳、21 个氢、3 个氮、3 个氧、1 个硫 组成。
别名/同义词：妥拉磺酰胺 · tolazamide
妥拉磺酰胺 的 CAS 登记号为 1156-19-0。
分子式 C14H21N3O3S，分子量 311.40。
别名/同义词：妥拉磺酰胺、tolazamide。
登记用途：Uses: Therap cat: Antidiabetic、An orally effective hypoglycemic drug.、For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.、Methods of Manufacturing: Prepn: Wright、Willette、J Med Pharm Chem 5、815 (1962)、Wright、British patent 887、886 (1962 to Upjohn).、METHYL P-TOLYLSULFONYLCARBAMATE IS CAUSED TO UNDERGO AMMONOLYSIS TYPE OF REACTION WITH 1-AMINOHEXAMETHYLENEIMINE、US PATENT 3、063、903.、Formulations、Preparations: ... usually administered in a daily dose of 100 to 250 mg、while 750 to 1000 mg is maximal.。
妥拉磺酰胺（CAS 1156-19-0）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 1156-19-0 |
|---|---|
| PubChem CID | 5503 |
| Molecular formula | C14H21N3O3S |
| IUPAC name | 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea |
| UNII (FDA) | 9LT1BRO48Q |
| Molecular Weight | 311.40 |
|---|---|
| XLogP3 | 1.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 311.13036271 |
| Monoisotopic Mass | 311.13036271 |
| Topological Polar Surface Area | 86.9 |
| Heavy Atom Count | 21 |
| Melting Point | 170-173 °C |
|---|---|
| Melting Point | 170 - 173 °C |
| Solubility | 65.4 |
| Solubility | In water, 65.4 mg/l @ 30 °C |
| Solubility | 3.08e-01 g/L |
| LogP | 2.69 |
| LogP | log Kow= 2.69 |
| LogP | 2.5 |
| LogP | 2.34 |
| Dissociation Constants | PKA @ 25 °C, 3.6; PKA @ 37.5 °C, 5.68 |
tolazamide; 1156-19-0; Tolinase; Norglycin; Tolanase; Tolazolamide; Diabewas; Tolazamida; Tolazamidum; 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea; NSC-70762; 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; U-17835; N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea; NCI-C03327; 4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
| GHS notification summary | 50% (1 / 2) |
|---|
| GHS notification summary | 50% (1 / 2) |
|---|---|
| Reported hazard statements | H370 (50%) |
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
H370 (50%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]
tolazamide · CAS 1156-19-0 · C14H21N3O3S. UNII 9LT1BRO48Q. Melting Point: 170-173 °C; Melting Point: 170 - 173 °C; Solubility: 65.4.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: tolazamide