Tibolone

Description

Tibolone · CAS 5630-53-5 · C21H28O2. UNII FF9X0205V2. Solubility: <0.1 g/L.

Identification

CAS Registry Number	5630-53-5
PubChem CID	444008
Molecular formula	C21H28O2
IUPAC name	(7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
UNII (FDA)	FF9X0205V2

Computed Descriptors

Molecular Weight	312.4
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	312.208930132
Monoisotopic Mass	312.208930132
Topological Polar Surface Area	37.3
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Solubility	<0.1 g/L

Regulatory Status

GHS notification summary	1.6% (1 / 63)

GHS Hazard Classification

GHS notification summary	1.6% (1 / 63)
Reported hazard statements	H319 (90.5%), H351 (30.2%), H372 (28.6%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >25
• Consumption (g per capita; approx.) in Germany (2009): 0.000305
• For the relief of post-menopausal symptoms and for the prevention of osteoporosis.
• Tibolone is a synthetic estrogen used for treatment of symptoms of menopause and prevention of osteoporosis. Tibolone has been associated with rare instances of acute, clinically apparent liver injury.
• Avoid St. John's Wort. St. John's Wort induces CYP3A4, increasing the metabolism of estrogens and progesterone and therefore reducing the efficacy of tibolone.
• Compounds which inhibit or antagonize the biosynthesis or actions of androgens.

Synonyms

tibolone; 5630-53-5; Liviella; Livial; Org OD 14; Tibolona; Xyvion; Tibolonum; DTXSID5023667; 17-Hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one; ORG-OD 14; FF9X0205V2; NSC-759898; DTXCID103667; CHEBI:32223; 17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one

Frequently Asked Questions

What are the CAS number and molecular formula of Tibolone?

CAS 5630-53-5; molecular formula C21H28O2; molecular weight — g/mol.

What other names is Tibolone known by?

tibolone, 5630-53-5, Liviella, Livial, Org OD 14, Tibolona.

Is Tibolone classified as hazardous?

1.6% of GHS notifications report no hazard classification (1 of 63).

What are the key physical properties of Tibolone?

Solubility: <0.1 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.