他莫昔芬

CAS 10540-29-1C26H29NOMW 371.5

他莫昔芬（CAS 10540-29-1）：分子式 C26H29NO、分子量 371.5。

产品概览

CAS号	10540-29-1
分子式	C26H29NO
分子量	371.5
熔点	97
LogP	7.1
应用领域	Uses: THERAP CAT: Antiestrogen、antineoplastic (hormonal)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 1160、Use (kg) in USA (2002): 186、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0142、Consumption (g per capita) in the USA (2002): 0.000659、Excretion rate: 0.5、Calculated removal (%): 97.2、Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.、Use Classification: Pharmaceuticals、Methods of Manufacturing: Tamoxifen is synthesized from appropriately substituted desoxybenzoin by an alkanol preparation by using standard methods and an olefinic link generated by an acid-catalyzed elimination reaction. Isomers are generated from this process in approximately a 1:1 ratio of Z (trans) and E (cis). These isomers can be separated by fractional crystallization to give the main functional (Z) form of tamoxifen.

应用领域

登记用途：Uses: THERAP CAT: Antiestrogen、antineoplastic (hormonal)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 1160、Use (kg) in USA (2002): 186、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0142、Consumption (g per capita) in the USA (2002): 0.000659、Excretion rate: 0.5、Calculated removal (%): 97.2、Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.、Use Classification: Pharmaceuticals、Methods of Manufacturing: Tamoxifen is synthesized from appropriately substituted desoxybenzoin by an alkanol preparation by using standard methods and an olefinic link generated by an acid-catalyzed elimination reaction. Isomers are generated from this process in approximately a 1:1 ratio of Z (trans) and E (cis). These isomers can be separated by fractional crystallization to give the main functional (Z) form of tamoxifen.。

技术档案

这个产品是什么

他莫昔芬是一种化工化合物，登记 CAS 号为 10540-29-1，分子式 C26H29NO（分子量 371.5）。

识别信息

登记 CAS 号：10540-29-1

其分子式 C26H29NO 由 26 个碳、29 个氢、1 个氮、1 个氧组成。

别名/同义词：他莫昔芬 · tamoxifen

常见问题

他莫昔芬的 CAS 号是多少？

他莫昔芬的 CAS 登记号为 10540-29-1。

他莫昔芬的分子式与分子量是多少？

分子式 C26H29NO，分子量 371.5。

他莫昔芬还有哪些别名？

别名/同义词：他莫昔芬、tamoxifen。

他莫昔芬的登记用途是什么？

PubChem 公开数据

他莫昔芬（CAS 10540-29-1）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

CAS Registry Number	10540-29-1
PubChem CID	2733526
Molecular formula	C26H29NO
IUPAC name	2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
UNII (FDA)	094ZI81Y45

计算分子描述符

Molecular Weight	371.5
XLogP3	7.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Exact Mass	371.224914549
Monoisotopic Mass	371.224914549
Topological Polar Surface Area	12.5
Heavy Atom Count	28

在册的理化数值

Melting Point	97
Melting Point	96-98 °C
Melting Point	97 °C
Solubility	1.02e-03 g/L
LogP	7.1
Dissociation Constants	8.48
Dissociation Constants	8.71
Dissociation Constants	10

在册的记载用途

同义词与商品名

tamoxifen; 10540-29-1; trans-Tamoxifen; Crisafeno; Tamoxifene; Diemon; Tamoxifeno; Citofen; Istubol; Oncomox; Retaxim; Tamizam; Tamoxen; Valodex; Tamoxifenum; Mammaton

GHS 危害分类

Reported hazard statements	H302 (58.3%), H350 (100%), H360 (91.7%), H362 (58.3%), H372 (33.3%), H400 (41.7%), H410 (41.7%)

H302 (58.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H350 (100%): May cause cancer [Danger Carcinogenicity]

公开数据库对它的描述

tamoxifen · CAS 10540-29-1 · C26H29NO. UNII 094ZI81Y45. Melting Point: 97; Melting Point: 96-98 °C; Melting Point: 97 °C.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。