磺胺二甲嘧啶（CAS 57-68-1）：分子式 C12H14N4O2S、分子量 278.33。
| CAS号 | 57-68-1 |
|---|---|
| 分子式 | C12H14N4O2S |
| 分子量 | 278.33 |
| 熔点 | 387 to 392 °F (NTP, 1992) |
| LogP | 0.89 |
| 应用领域 | Uses: MEDICATION (VET)、Anti-Infective agents、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Pharmaceuticals -> Antiinfectives for systemic use -> Antibacterials for systemic use -> Sulfonamides and trimethoprims -> Short-acting sulfonamides -> Antibiotics、Methods of Manufacturing: Sulfamethazine can be prepared by reacting acetylsulfanilyl chloride with 2-amino- 4、6-dimethylpyrimidine suspended in dry pyridine or in acetone and pyridine、followed by alkaline hydrolysis of the 2-(N4-acetylsulfanilamido)-4、6-dimethylpyrimidine、the resulting salt is neutralized with SO2. The 2-amino-4、6-dimethylpyrimidine is prepared by condensing acetylacetone with guanidine carbonate in toluene. It can also be prepared by condensation of equimolar amounts of sulfanilylguanidine and acetylacetone directly. It is precipitated in the presence of water in the form of very pale yellow crystals.、Formulations、Preparations: THERE IS NO OFFICIAL DOSE FORM FOR SULFAMETHAZINE ALONE BECAUSE IT IS OFFICIAL ONLY FOR USE IN TRISULFAPYRIMIDINES COMBINATION. HOWEVER、IT MAY BE USED SEPARATELY FROM TRISULFAPYRIMIDINES COMBINATION.、SRP: Former、Oral: Sustain III Calf (Sulfamethazine)、Formulated in a sustained release base)、123.8 grains (8.02 grams)、Oral: Sulmet (Sulfamethazine sodium)、Drinking Water Solution、12.5%、Sulfamethazine sodium、Oral: SMZ-Med 454 (Sodium sulfamethazine) soluble powder、once a day dosage in drinking water or as a drench.、Sodium sulfamethazine、For more Formulations、Preparations (Complete) data for SULFAMETHAZINE (8 total)、please visit the HSDB record page.、U.S. Production: (1977) PROBABLY GREATER THAN 1.36X10+6 GRAMS、(1979) 6.16X10+8 GRAMS、U.S. Imports: (1977) 4.92X10+8 GRAMS (PRINCPL CUSTMS DISTS)、(1979) 1.01X10+9 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Benzenesulfonamide、4-amino-N-(4、6-dimethyl-2-pyrimidinyl)-: ACTIVE、Sulfamethazine is frequently found as an illegal residue in meats in the United States. |
登记用途：Uses: MEDICATION (VET)、Anti-Infective agents、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Pharmaceuticals -> Antiinfectives for systemic use -> Antibacterials for systemic use -> Sulfonamides and trimethoprims -> Short-acting sulfonamides -> Antibiotics、Methods of Manufacturing: Sulfamethazine can be prepared by reacting acetylsulfanilyl chloride with 2-amino- 4、6-dimethylpyrimidine suspended in dry pyridine or in acetone and pyridine、followed by alkaline hydrolysis of the 2-(N4-acetylsulfanilamido)-4、6-dimethylpyrimidine、the resulting salt is neutralized with SO2. The 2-amino-4、6-dimethylpyrimidine is prepared by condensing acetylacetone with guanidine carbonate in toluene. It can also be prepared by condensation of equimolar amounts of sulfanilylguanidine and acetylacetone directly. It is precipitated in the presence of water in the form of very pale yellow crystals.、Formulations、Preparations: THERE IS NO OFFICIAL DOSE FORM FOR SULFAMETHAZINE ALONE BECAUSE IT IS OFFICIAL ONLY FOR USE IN TRISULFAPYRIMIDINES COMBINATION. HOWEVER、IT MAY BE USED SEPARATELY FROM TRISULFAPYRIMIDINES COMBINATION.、SRP: Former、Oral: Sustain III Calf (Sulfamethazine)、Formulated in a sustained release base)、123.8 grains (8.02 grams)、Oral: Sulmet (Sulfamethazine sodium)、Drinking Water Solution、12.5%、Sulfamethazine sodium、Oral: SMZ-Med 454 (Sodium sulfamethazine) soluble powder、once a day dosage in drinking water or as a drench.、Sodium sulfamethazine、For more Formulations、Preparations (Complete) data for SULFAMETHAZINE (8 total)、please visit the HSDB record page.、U.S. Production: (1977) PROBABLY GREATER THAN 1.36X10+6 GRAMS、(1979) 6.16X10+8 GRAMS、U.S. Imports: (1977) 4.92X10+8 GRAMS (PRINCPL CUSTMS DISTS)、(1979) 1.01X10+9 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Benzenesulfonamide、4-amino-N-(4、6-dimethyl-2-pyrimidinyl)-: ACTIVE、Sulfamethazine is frequently found as an illegal residue in meats in the United States.。
磺胺二甲嘧啶 是一种化工化合物，登记 CAS 号为 57-68-1，分子式 C12H14N4O2S（分子量 278.33）。
登记 CAS 号：57-68-1
其分子式 C12H14N4O2S 由 12 个碳、14 个氢、4 个氮、2 个氧、1 个硫 组成。
别名/同义词：磺胺二甲嘧啶 · SULFAMETHAZINE
磺胺二甲嘧啶 的 CAS 登记号为 57-68-1。
分子式 C12H14N4O2S，分子量 278.33。
别名/同义词：磺胺二甲嘧啶、SULFAMETHAZINE。
登记用途：Uses: MEDICATION (VET)、Anti-Infective agents、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Pharmaceuticals -> Antiinfectives for systemic use -> Antibacterials for systemic use -> Sulfonamides and trimethoprims -> Short-acting sulfonamides -> Antibiotics、Methods of Manufacturing: Sulfamethazine can be prepared by reacting acetylsulfanilyl chloride with 2-amino- 4、6-dimethylpyrimidine suspended in dry pyridine or in acetone and pyridine、followed by alkaline hydrolysis of the 2-(N4-acetylsulfanilamido)-4、6-dimethylpyrimidine、the resulting salt is neutralized with SO2. The 2-amino-4、6-dimethylpyrimidine is prepared by condensing acetylacetone with guanidine carbonate in toluene. It can also be prepared by condensation of equimolar amounts of sulfanilylguanidine and acetylacetone directly. It is precipitated in the presence of water in the form of very pale yellow crystals.、Formulations、Preparations: THERE IS NO OFFICIAL DOSE FORM FOR SULFAMETHAZINE ALONE BECAUSE IT IS OFFICIAL ONLY FOR USE IN TRISULFAPYRIMIDINES COMBINATION. HOWEVER、IT MAY BE USED SEPARATELY FROM TRISULFAPYRIMIDINES COMBINATION.、SRP: Former、Oral: Sustain III Calf (Sulfamethazine)、Formulated in a sustained release base)、123.8 grains (8.02 grams)、Oral: Sulmet (Sulfamethazine sodium)、Drinking Water Solution、12.5%、Sulfamethazine sodium、Oral: SMZ-Med 454 (Sodium sulfamethazine) soluble powder、once a day dosage in drinking water or as a drench.、Sodium sulfamethazine、For more Formulations、Preparations (Complete) data for SULFAMETHAZINE (8 total)、please visit the HSDB record page.、U.S. Production: (1977) PROBABLY GREATER THAN 1.36X10+6 GRAMS、(1979) 6.16X10+8 GRAMS、U.S. Imports: (1977) 4.92X10+8 GRAMS (PRINCPL CUSTMS DISTS)、(1979) 1.01X10+9 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Benzenesulfonamide、4-amino-N-(4、6-dimethyl-2-pyrimidinyl)-: ACTIVE、Sulfamethazine is frequently found as an illegal residue in meats in the United States.。
磺胺二甲嘧啶（CAS 57-68-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 57-68-1 |
|---|---|
| PubChem CID | 5327 |
| Molecular formula | C12H14N4O2S |
| IUPAC name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| UNII (FDA) | 48U51W007F |
| Molecular Weight | 278.33 |
|---|---|
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 278.08374688 |
| Monoisotopic Mass | 278.08374688 |
| Topological Polar Surface Area | 106 |
| Heavy Atom Count | 19 |
| Melting Point | 387 to 392 °F (NTP, 1992) |
|---|---|
| Melting Point | 198.5 |
| Melting Point | 198.5 °C |
| Solubility | 1500 |
| Solubility | 2.30e-01 g/L |
| Density | 1.4655 g/cu cm |
| LogP | 0.89 |
| LogP | log Kow = 0.14 |
| LogP | 0.21 |
| Dissociation Constants | 7.59 |
sulfamethazine; Sulfadimidine; 57-68-1; Sulfadimerazine; Sulphamethazine; Sulfamezathine; Sulphadimidine; 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide; Sulfadimethylpyrimidine; Sulfadimezine; Sulfadimethyldiazine; Sulfadimesine; Sulphamezathine; Sulphamidine; Sulfadine; Sulfamethiazine
| Regulatory & Food Contact | ANTIMICROBIAL_AGENT: Veterinary Drug JECFA ADI: 0-0.05 mg/kg bw TRS 851-JECFA 42/25 FAS 33-JECFA 42/91 SULFAMIDINE |
|---|---|
| GHS notification summary | 18.8% (9 / 48) |
| GHS notification summary | 18.8% (9 / 48) |
|---|---|
| Reported hazard statements | H315 (75%), H319 (75%) |
This chemical does not meet GHS hazard criteria for 18.8% (9 of 48) of reports.
H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
SULFAMETHAZINE · CAS 57-68-1 · C12H14N4O2S. UNII 48U51W007F. Melting Point: 387 to 392 °F (NTP, 1992); Melting Point: 198.5; Melting Point: 198.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: SULFAMETHAZINE