Sucralose（CAS 56038-13-2）：分子式 C12H19Cl3O8、分子量 397.6。
| CAS号 | 56038-13-2 |
|---|---|
| 分子式 | C12H19Cl3O8 |
| 分子量 | 397.6 |
| 熔点 | 130 °C |
| LogP | -1.5 |
| 应用领域 | Uses: CIR ingredient: Sucralose、Chlorinated derivative of sucrose、Used as a non-nutritive sweetener、[Merck Index]、Flavor enhancer、Add sweetness with or without the extra calories ...、in、beverages、baked goods、confections、table-top sugar、substitutes、many processed foods、Non-nutritive sweetener、Use Classification: Food additives、Food Additives -> SWEETENER -> JECFA Functional Classes、Household Products: Information on 39 consumer products that contain Sucralose in the following categories is provided:、• Personal Care、Methods of Manufacturing: The starting material for the synthesis of sucralose is sucrose. The production route commonly described blocks the three primary hydroxyl groups as trityl ethers、and transforms the secondary hydroxyl groups to acetates to yield 6、1'、6'-tritrityl-2、3、4、3'、4'- pentaacetylsucrose. By deblocking the primary hydroxyl groups、2、4'-pentaacetylsucrose is obtained. Under appropriate conditions、this compound can be transformed to 2、6、4'- pentaacetylsucrose. Chlorination at the exposed hydroxyl groups gives 4、6'-trichloro-4、6'- tridesoxygalactosucrose on conversion of the glucose moiety to galactose. Removal of the acetate groups by hydrolysis yields sucralose.、Formulations、Preparations: Aqueous solutions、U.S. Production: 2022: 8、929 lb、General Manufacturing Information: Chlorinated sucrose derivative with enhanced sweetness、Compared with dilute sucrose solution、sucralose is about 600 times sweeter. The sweetness is perceived with a slight delay and a lasting effect、similar to aspartame、and generally considered of good quality.、Solid sucralose is not fully stable、and slowly releases HCl、with discoloration. In contrast、aqueous solutions are highly stable、and it is marketed in this form. |
登记用途：Uses: CIR ingredient: Sucralose、Chlorinated derivative of sucrose、Used as a non-nutritive sweetener、[Merck Index]、Flavor enhancer、Add sweetness with or without the extra calories ...、in、beverages、baked goods、confections、table-top sugar、substitutes、many processed foods、Non-nutritive sweetener、Use Classification: Food additives、Food Additives -> SWEETENER -> JECFA Functional Classes、Household Products: Information on 39 consumer products that contain Sucralose in the following categories is provided:、• Personal Care、Methods of Manufacturing: The starting material for the synthesis of sucralose is sucrose. The production route commonly described blocks the three primary hydroxyl groups as trityl ethers、and transforms the secondary hydroxyl groups to acetates to yield 6、1'、6'-tritrityl-2、3、4、3'、4'- pentaacetylsucrose. By deblocking the primary hydroxyl groups、2、4'-pentaacetylsucrose is obtained. Under appropriate conditions、this compound can be transformed to 2、6、4'- pentaacetylsucrose. Chlorination at the exposed hydroxyl groups gives 4、6'-trichloro-4、6'- tridesoxygalactosucrose on conversion of the glucose moiety to galactose. Removal of the acetate groups by hydrolysis yields sucralose.、Formulations、Preparations: Aqueous solutions、U.S. Production: 2022: 8、929 lb、General Manufacturing Information: Chlorinated sucrose derivative with enhanced sweetness、Compared with dilute sucrose solution、sucralose is about 600 times sweeter. The sweetness is perceived with a slight delay and a lasting effect、similar to aspartame、and generally considered of good quality.、Solid sucralose is not fully stable、and slowly releases HCl、with discoloration. In contrast、aqueous solutions are highly stable、and it is marketed in this form.。
Sucralose 是一种化工化合物，登记 CAS 号为 56038-13-2，分子式 C12H19Cl3O8（分子量 397.6）。
登记 CAS 号：56038-13-2
其分子式 C12H19Cl3O8 由 12 个碳、19 个氢、3 个氯、8 个氧 组成。
别名/同义词：Sucralose
Sucralose 的 CAS 登记号为 56038-13-2。
分子式 C12H19Cl3O8，分子量 397.6。
别名/同义词：Sucralose。
登记用途：Uses: CIR ingredient: Sucralose、Chlorinated derivative of sucrose、Used as a non-nutritive sweetener、[Merck Index]、Flavor enhancer、Add sweetness with or without the extra calories ...、in、beverages、baked goods、confections、table-top sugar、substitutes、many processed foods、Non-nutritive sweetener、Use Classification: Food additives、Food Additives -> SWEETENER -> JECFA Functional Classes、Household Products: Information on 39 consumer products that contain Sucralose in the following categories is provided:、• Personal Care、Methods of Manufacturing: The starting material for the synthesis of sucralose is sucrose. The production route commonly described blocks the three primary hydroxyl groups as trityl ethers、and transforms the secondary hydroxyl groups to acetates to yield 6、1'、6'-tritrityl-2、3、4、3'、4'- pentaacetylsucrose. By deblocking the primary hydroxyl groups、2、4'-pentaacetylsucrose is obtained. Under appropriate conditions、this compound can be transformed to 2、6、4'- pentaacetylsucrose. Chlorination at the exposed hydroxyl groups gives 4、6'-trichloro-4、6'- tridesoxygalactosucrose on conversion of the glucose moiety to galactose. Removal of the acetate groups by hydrolysis yields sucralose.、Formulations、Preparations: Aqueous solutions、U.S. Production: 2022: 8、929 lb、General Manufacturing Information: Chlorinated sucrose derivative with enhanced sweetness、Compared with dilute sucrose solution、sucralose is about 600 times sweeter. The sweetness is perceived with a slight delay and a lasting effect、similar to aspartame、and generally considered of good quality.、Solid sucralose is not fully stable、and slowly releases HCl、with discoloration. In contrast、aqueous solutions are highly stable、and it is marketed in this form.。
Sucralose（CAS 56038-13-2）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 56038-13-2 |
|---|---|
| PubChem CID | 71485 |
| 分子式 | C12H19Cl3O8 |
| 分子量 | 396.01 g/mol |
| IUPAC 名称 | (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol |
| InChIKey | BAQAVOSOZGMPRM-QBMZZYIRSA-N |
| UNII（FDA） | 96K6UQ3ZD4 |
| ChEBI 编号 | CHEBI:32159 |
| Molecular Weight | 397.6 |
|---|---|
| XLogP3 | -1.5 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 5 |
| Exact Mass | 396.014551 |
| Monoisotopic Mass | 396.014551 |
| Topological Polar Surface Area | 129 |
| Heavy Atom Count | 23 |
| Melting Point | 130 °C |
|---|---|
| Collision Cross Section | 179.16 Ų [M-H]- |
Sucralose; 56038-13-2; Splenda; Trichlorosucrose; Aspasvit; Sucrazit; Trichlorogalactosucrose; Trichlorogalacto-sucrose; Sansweet su 100; 96K6UQ3ZD4; 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside; San sweet sa 8020; DTXSID1040245; INS-955; 4,1',6'-trichlorogalactosucrose; NSC-759272
| 法规与食品接触 | FDA Substance added to food: NUTRITIVE SWEETENER SWEETENER: Food Additives JECFA ADI: 0-15 mg/kg bw TRS 806-JECFA 37/21 FAS 28-JECFA 37/219 CIR / INCI: Cosmetic ingredients (Sucralose) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS 通报统计 | 100% (309 / 309) |
| GHS 通报统计 | 100% (309 / 309) |
|---|
Sucralose 的 CAS 号为 56038-13-2，分子式 C12H19Cl3O8，分子量 396.01 g/mol。 UNII 96K6UQ3ZD4; ChEBI 32159; InChIKey BAQAVOSOZGMPRM-QBMZZYIRSA-N. Melting Point: 130 °C; Collision Cross Section: 179.16 Ų [M-H]-.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Sucralose