链脲佐菌素（CAS 66395-18-4）：分子式 C8H15N3O7、分子量 265.22。
| CAS号 | 66395-18-4 |
|---|---|
| 分子式 | C8H15N3O7 |
| 分子量 | 265.22 |
| 熔点 | 115 |
| LogP | -1.45 |
| 应用领域 | Uses: Produced by Streptomyces achromogenas (soil microorganisms)、Used to produce diabetes in experimental animals and as an antineoplastic agent、[HSDB]、EMPLOYED AS DIABETOGENIC AGENT IN EXPERIMENTAL ANIMALS.、PRODUCTION OF EXPTL DIABETES IN LAB ANIMALS、ANTINEOPLASTIC.、MEDICATION、MEDICATION (VET)、For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).、Methods of Manufacturing: PURIFICATION FROM STREPTOMYCES ACHROMOGENES CULTURES、SYNTHESIS FROM TETRA-O-ACETYL GLUCOSAMINE HYDROCHLORIDE、REACTION OF D-GLUCOSAMINE WITH N-NITROSOMETHYLCARBAMYLAZIDE OR N-METHYLISOCYANATE.、ISOLATION FROM STREPTOMYCES ACHROMOGENES FERMENTATION BROTH.、Formulations、Preparations: Streptozotocin is available in 1 g vials as a powder for injection.、Commercially available streptozocin for injection occurs as a sterile、pale yellow、lyophilized powder and contains anhydrous citric acid as a buffer、sodium hydroxide is added during manufacture of the powder for injection to adjust pH.、U.S. Production: (1977) PROBABLY GREATER THAN 9.08X10+5 GRAMS、(1979) PROBABLY GREATER THAN 9.08X10+5 GRAMS、General Manufacturing Information:、Streptozotocin、is active against gram positive and gram negative bacteria、but its cytotoxicity precludes its use as an anti-infective agent. |
登记用途：Uses: Produced by Streptomyces achromogenas (soil microorganisms)、Used to produce diabetes in experimental animals and as an antineoplastic agent、[HSDB]、EMPLOYED AS DIABETOGENIC AGENT IN EXPERIMENTAL ANIMALS.、PRODUCTION OF EXPTL DIABETES IN LAB ANIMALS、ANTINEOPLASTIC.、MEDICATION、MEDICATION (VET)、For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).、Methods of Manufacturing: PURIFICATION FROM STREPTOMYCES ACHROMOGENES CULTURES、SYNTHESIS FROM TETRA-O-ACETYL GLUCOSAMINE HYDROCHLORIDE、REACTION OF D-GLUCOSAMINE WITH N-NITROSOMETHYLCARBAMYLAZIDE OR N-METHYLISOCYANATE.、ISOLATION FROM STREPTOMYCES ACHROMOGENES FERMENTATION BROTH.、Formulations、Preparations: Streptozotocin is available in 1 g vials as a powder for injection.、Commercially available streptozocin for injection occurs as a sterile、pale yellow、lyophilized powder and contains anhydrous citric acid as a buffer、sodium hydroxide is added during manufacture of the powder for injection to adjust pH.、U.S. Production: (1977) PROBABLY GREATER THAN 9.08X10+5 GRAMS、(1979) PROBABLY GREATER THAN 9.08X10+5 GRAMS、General Manufacturing Information:、Streptozotocin、is active against gram positive and gram negative bacteria、but its cytotoxicity precludes its use as an anti-infective agent.。
链脲佐菌素 是一种化工化合物，登记 CAS 号为 66395-18-4，分子式 C8H15N3O7（分子量 265.22）。
登记 CAS 号：66395-18-4
其分子式 C8H15N3O7 由 8 个碳、15 个氢、3 个氮、7 个氧 组成。
别名/同义词：链脲佐菌素 · Streptozocin
链脲佐菌素 的 CAS 登记号为 66395-18-4。
分子式 C8H15N3O7，分子量 265.22。
别名/同义词：链脲佐菌素、Streptozocin。
登记用途：Uses: Produced by Streptomyces achromogenas (soil microorganisms)、Used to produce diabetes in experimental animals and as an antineoplastic agent、[HSDB]、EMPLOYED AS DIABETOGENIC AGENT IN EXPERIMENTAL ANIMALS.、PRODUCTION OF EXPTL DIABETES IN LAB ANIMALS、ANTINEOPLASTIC.、MEDICATION、MEDICATION (VET)、For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).、Methods of Manufacturing: PURIFICATION FROM STREPTOMYCES ACHROMOGENES CULTURES、SYNTHESIS FROM TETRA-O-ACETYL GLUCOSAMINE HYDROCHLORIDE、REACTION OF D-GLUCOSAMINE WITH N-NITROSOMETHYLCARBAMYLAZIDE OR N-METHYLISOCYANATE.、ISOLATION FROM STREPTOMYCES ACHROMOGENES FERMENTATION BROTH.、Formulations、Preparations: Streptozotocin is available in 1 g vials as a powder for injection.、Commercially available streptozocin for injection occurs as a sterile、pale yellow、lyophilized powder and contains anhydrous citric acid as a buffer、sodium hydroxide is added during manufacture of the powder for injection to adjust pH.、U.S. Production: (1977) PROBABLY GREATER THAN 9.08X10+5 GRAMS、(1979) PROBABLY GREATER THAN 9.08X10+5 GRAMS、General Manufacturing Information:、Streptozotocin、is active against gram positive and gram negative bacteria、but its cytotoxicity precludes its use as an anti-infective agent.。
链脲佐菌素（CAS 66395-18-4）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 66395-18-4 |
|---|---|
| PubChem CID | 29327 |
| Molecular formula | C8H15N3O7 |
| IUPAC name | 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea |
| UNII (FDA) | 8H27GUR065 |
| Molecular Weight | 265.22 |
|---|---|
| XLogP3 | -1.4 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 2 |
| Exact Mass | 265.09099983 |
| Monoisotopic Mass | 265.09099983 |
| Topological Polar Surface Area | 152 |
| Heavy Atom Count | 18 |
| Melting Point | 115 |
|---|---|
| Melting Point | 115 °C |
| Solubility | 5070 |
| Solubility | 3.35e+01 g/L |
| LogP | -1.45 |
| LogP | -1.7 |
| Dissociation Constants | pKa= 1.35 |
streptozocin; STREPTOZOTOCIN; 18883-66-4; Streptozocinium; Streptozocinum; STRZ; Streptozoticin; Streptozocinium [Latin]; DTXSID2021282; N-D-Glucosyl-(2)-N'-nitrosomethylurea; CHEBI:9288; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff; 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
| GHS notification summary | 1.8% (1 / 57) |
|---|
| GHS notification summary | 1.8% (1 / 57) |
|---|---|
| Reported hazard statements | H312 (22.8%), H332 (22.8%), H340 (22.8%), H350 (96.5%), H360 (22.8%), H301, H341, H351 |
This chemical does not meet GHS hazard criteria for 1.8% (1 of 57) of reports.
H312 (22.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
Streptozocin · CAS 66395-18-4 · C8H15N3O7. UNII 8H27GUR065. Melting Point: 115; Melting Point: 115 °C; Solubility: 5070.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Streptozocin