Stavudine（CAS 220020-60-0）：分子式 C10H12N2O4、分子量 224.21。
| CAS号 | 220020-60-0 |
|---|---|
| 分子式 | C10H12N2O4 |
| 分子量 | 224.21 |
| 熔点 | 318 to 320 °F (NTP, 1992) |
| LogP | -0.72 |
| 应用领域 | Uses: Antiviral、Medication、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 1200、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.00425、Calculated removal (%): 75.1、For the treatment of human immunovirus (HIV) infections.、Methods of Manufacturing: Large scale production: J.E. Starrett et al、EP 334368、eidem、US 5130421 (1989、1992 both to Bristol-Myers)、Formulations、Preparations: Zerit、Oral: Capsules: 15 mg Zerit (with parabens)、(Bristol-Myers Squibb)、20 mg Zerit (with parabens)、(Bristol-Myers Squibb) 30 mg Zerit (with parabens)、(Bristol-Myers Squibb) 40 mg Zerit (with parabens)、For solution: 1 mg、mL Zerit (with parabens)、(Bristol-Myers Squibb).、General Manufacturing Information: While data specific to stavudine were not available(SRC、2005)、the literature suggests that some pharmaceutically active compounds originating from human and veterinary therapy are not eliminated completely in municipal sewage treatment plants and are therefore discharged into receiving waters(1). Wastewater treatment processes often were not designed to remove them from the effluent(2). Selected organic waste compounds may be degrading to new and more persistent compounds that may be released instead of or in addition to the parent compound(2). Studies have indicated that several polar pharmaceutically active compounds can leach through subsoils into aquifers(1). |
登记用途：Uses: Antiviral、Medication、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 1200、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.00425、Calculated removal (%): 75.1、For the treatment of human immunovirus (HIV) infections.、Methods of Manufacturing: Large scale production: J.E. Starrett et al、EP 334368、eidem、US 5130421 (1989、1992 both to Bristol-Myers)、Formulations、Preparations: Zerit、Oral: Capsules: 15 mg Zerit (with parabens)、(Bristol-Myers Squibb)、20 mg Zerit (with parabens)、(Bristol-Myers Squibb) 30 mg Zerit (with parabens)、(Bristol-Myers Squibb) 40 mg Zerit (with parabens)、For solution: 1 mg、mL Zerit (with parabens)、(Bristol-Myers Squibb).、General Manufacturing Information: While data specific to stavudine were not available(SRC、2005)、the literature suggests that some pharmaceutically active compounds originating from human and veterinary therapy are not eliminated completely in municipal sewage treatment plants and are therefore discharged into receiving waters(1). Wastewater treatment processes often were not designed to remove them from the effluent(2). Selected organic waste compounds may be degrading to new and more persistent compounds that may be released instead of or in addition to the parent compound(2). Studies have indicated that several polar pharmaceutically active compounds can leach through subsoils into aquifers(1).。
Stavudine 是一种化工化合物，登记 CAS 号为 220020-60-0，分子式 C10H12N2O4（分子量 224.21）。
登记 CAS 号：220020-60-0
其分子式 C10H12N2O4 由 10 个碳、12 个氢、2 个氮、4 个氧 组成。
别名/同义词：Stavudine
Stavudine 的 CAS 登记号为 220020-60-0。
分子式 C10H12N2O4，分子量 224.21。
别名/同义词：Stavudine。
登记用途：Uses: Antiviral、Medication、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 1200、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.00425、Calculated removal (%): 75.1、For the treatment of human immunovirus (HIV) infections.、Methods of Manufacturing: Large scale production: J.E. Starrett et al、EP 334368、eidem、US 5130421 (1989、1992 both to Bristol-Myers)、Formulations、Preparations: Zerit、Oral: Capsules: 15 mg Zerit (with parabens)、(Bristol-Myers Squibb)、20 mg Zerit (with parabens)、(Bristol-Myers Squibb) 30 mg Zerit (with parabens)、(Bristol-Myers Squibb) 40 mg Zerit (with parabens)、For solution: 1 mg、mL Zerit (with parabens)、(Bristol-Myers Squibb).、General Manufacturing Information: While data specific to stavudine were not available(SRC、2005)、the literature suggests that some pharmaceutically active compounds originating from human and veterinary therapy are not eliminated completely in municipal sewage treatment plants and are therefore discharged into receiving waters(1). Wastewater treatment processes often were not designed to remove them from the effluent(2). Selected organic waste compounds may be degrading to new and more persistent compounds that may be released instead of or in addition to the parent compound(2). Studies have indicated that several polar pharmaceutically active compounds can leach through subsoils into aquifers(1).。
Stavudine（CAS 220020-60-0）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 220020-60-0 |
|---|---|
| PubChem CID | 18283 |
| Molecular formula | C10H12N2O4 |
| IUPAC name | 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione |
| UNII (FDA) | BO9LE4QFZF |
| Molecular Weight | 224.21 |
|---|---|
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 224.07970687 |
| Monoisotopic Mass | 224.07970687 |
| Topological Polar Surface Area | 78.9 |
| Heavy Atom Count | 16 |
| Melting Point | 318 to 320 °F (NTP, 1992) |
|---|---|
| Melting Point | 159-160 °C |
| Melting Point | 165-166 °C |
| Melting Point | 159 - 160 °C |
| Solubility | 50 to 100 mg/mL at 70 °F (NTP, 1992) |
| Solubility | 5-10 g/100 mL at 21 °C |
| Solubility | In water, 83 mg/mL at 23 °C |
| Solubility | 4.05e+01 g/L |
| LogP | -0.72 |
| LogP | log Kow = -0.72 at 37 °C |
stavudine; 3056-17-5; sanilvudine; Zerit; 2',3'-Didehydro-3'-deoxythymidine; Estavudina; Stavudinum; Thymidine, 2',3'-didehydro-3'-deoxy-; Zerit Xr; BMY-27857; 3'-Deoxy-2'-thymidinene; 1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; D 4T (nucleoside); 2',3'-Didehydro-3'-deoxythimidine; 3'-Deoxy-2',3'-didehydrothymidine; BMY 27857
| Reported hazard statements | H302 (66.7%), H315 (33.3%), H319 (33.3%), H335 (33.3%), H341 (33.3%), H361 (33.3%), H362 (33.3%), H372 (33.3%) |
|---|
H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation]
Stavudine · CAS 220020-60-0 · C10H12N2O4. UNII BO9LE4QFZF. Melting Point: 318 to 320 °F (NTP, 1992); Melting Point: 159-160 °C; Melting Point: 165-166 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Stavudine