次甲基蓝（三水）（CAS 12262-49-6）：分子式 C16H18N3S.Cl、分子量 319.9。
| CAS号 | 12262-49-6 |
|---|---|
| 分子式 | C16H18N3S.Cl |
| 分子量 | 319.9 |
| 熔点 | 100 |
| 应用领域 | Uses: Used as a stain in bacteriology、a chemical reagent、an antimethemoglobinemic drug、a polymerization inhibitor、and a temporary hair colorant、also used as a paper、textile、and leather dye、[HSDB] Azine dye、[Kirk-Othmer]、Pulp and Paper Processing [Category: Industry]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For methylene blue (USEPA、OPP Pesticide Code: 039505) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Stain in bacteriology、reagent for several chemicals、as mixed indicator、as redox colorimetric agent. Targeting agent for melanoma.、Dyeing cotton and wool、biological and bacteriological stains、reagent in oxidation-reduction titrations in volumetric analysis、indicator、Methylene blue is mainly used to dye paper and office supplies、but also to tone up silk colors. ... as a stain in microscopy、as a hydrogen acceptor in enzymatic dehydrogenations、as a redox indicator in iodometry and titanometry、and as a cosmetic dye.、For more Uses (Complete) data for Methylene blue (8 total)、please visit the HSDB record page.、Use Classification: Cosmetics -> Hair dyeing、Household Products: Information on 1 consumer products that contain Methylene blue in the following categories is provided:、• Commercial、Institutional、Information on 2 consumer products that contain Methylene blue in the following categories is provided:、• Pet Care、Methods of Manufacturing: Methylene blue ... is obtained by oxidation of 4-aminodimethylaniline in the presence of sodium thiosulfate to give the quinonediiminothiosulfonic acid、reaction with dimethylaniline、oxidation to the indamine、and cyclization to give the thiazine. The dye is commercially available as the hydrochloride and as the zinc chloride double salt.、By treating a solution of N、N-dimethyl-p-phenylenediamine and N、N、-dimethylaniline hydrochlorides with H2S and FeCl3 or another suitable oxidizing agent.、By oxidation of p-aminodimethylaniline with ferric chloride in the presence of hydrogen sulfide. The dye is the zinc chloride double salt of the chloride.、N-Dimethyl-p-phenylene diamine ... reacts with sodium thiosulfate ... to form the thiosulfonic acid which condenses with N、N-dimethylaniline ... in the presence of sodium dichromate ... to the indamine、then with copper sulfate ... and sodium dichromate to methylene blue.、Impurities: 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ylium、Formulations、Preparations: Provided technically as the zinc double chloride、used medically in a zinc free form.、Parenteral: Injection、for IV use、10 mg、mL (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name)、Grade: USP、technical.、U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3133]、General Manufacturing Information: Phenothiazin-5-ium、3、7-bis(dimethylamino)-、chloride (1:1): ACTIVE、C16H18N3SCl.3H2O (medicinal)、(C16H18N3SCl)2.ZnCl2H20 (dye)、Methylene blue has also been described as a "photosensitizer" which means that it can absorb light and transfer the absorbed energy to another compound.、Methylene blue was first isolated in 1876. Its use covers many areas、including as an antiseptic、disinfectant、and cyanide-antidote. Methylene blue is also an antimicrobial agent in plastic materials such as food packaging wraps、surgical drapes、face masks、and other film materials. Light exposure of the dye dispersed in plastic generates reactive singlet oxygen、which is the active antimicrobial species. Methylene blue is approved for topical、intravenous、and oral administration. Its cellular adsorption selectivity、subcellular localization、reduction to leuko-dye by mitochondria、and photoreaction with DNA have been of interest for decades. Recent applications of this technology to HIV phototherapy have reviewed previous methylene blue literature .、Thiazine dyes are generally of minor importance in the textile field due to what is presently considered as inferior fastness |
登记用途：Uses: Used as a stain in bacteriology、a chemical reagent、an antimethemoglobinemic drug、a polymerization inhibitor、and a temporary hair colorant、also used as a paper、textile、and leather dye、[HSDB] Azine dye、[Kirk-Othmer]、Pulp and Paper Processing [Category: Industry]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For methylene blue (USEPA、OPP Pesticide Code: 039505) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Stain in bacteriology、reagent for several chemicals、as mixed indicator、as redox colorimetric agent. Targeting agent for melanoma.、Dyeing cotton and wool、biological and bacteriological stains、reagent in oxidation-reduction titrations in volumetric analysis、indicator、Methylene blue is mainly used to dye paper and office supplies、but also to tone up silk colors. ... as a stain in microscopy、as a hydrogen acceptor in enzymatic dehydrogenations、as a redox indicator in iodometry and titanometry、and as a cosmetic dye.、For more Uses (Complete) data for Methylene blue (8 total)、please visit the HSDB record page.、Use Classification: Cosmetics -> Hair dyeing、Household Products: Information on 1 consumer products that contain Methylene blue in the following categories is provided:、• Commercial、Institutional、Information on 2 consumer products that contain Methylene blue in the following categories is provided:、• Pet Care、Methods of Manufacturing: Methylene blue ... is obtained by oxidation of 4-aminodimethylaniline in the presence of sodium thiosulfate to give the quinonediiminothiosulfonic acid、reaction with dimethylaniline、oxidation to the indamine、and cyclization to give the thiazine. The dye is commercially available as the hydrochloride and as the zinc chloride double salt.、By treating a solution of N、N-dimethyl-p-phenylenediamine and N、N、-dimethylaniline hydrochlorides with H2S and FeCl3 or another suitable oxidizing agent.、By oxidation of p-aminodimethylaniline with ferric chloride in the presence of hydrogen sulfide. The dye is the zinc chloride double salt of the chloride.、N-Dimethyl-p-phenylene diamine ... reacts with sodium thiosulfate ... to form the thiosulfonic acid which condenses with N、N-dimethylaniline ... in the presence of sodium dichromate ... to the indamine、then with copper sulfate ... and sodium dichromate to methylene blue.、Impurities: 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ylium、Formulations、Preparations: Provided technically as the zinc double chloride、used medically in a zinc free form.、Parenteral: Injection、for IV use、10 mg、mL (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name)、Grade: USP、technical.、U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3133]、General Manufacturing Information: Phenothiazin-5-ium、3、7-bis(dimethylamino)-、chloride (1:1): ACTIVE、C16H18N3SCl.3H2O (medicinal)、(C16H18N3SCl)2.ZnCl2H20 (dye)、Methylene blue has also been described as a "photosensitizer" which means that it can absorb light and transfer the absorbed energy to another compound.、Methylene blue was first isolated in 1876. Its use covers many areas、including as an antiseptic、disinfectant、and cyanide-antidote. Methylene blue is also an antimicrobial agent in plastic materials such as food packaging wraps、surgical drapes、face masks、and other film materials. Light exposure of the dye dispersed in plastic generates reactive singlet oxygen、which is the active antimicrobial species. Methylene blue is approved for topical、intravenous、and oral administration. Its cellular adsorption selectivity、subcellular localization、reduction to leuko-dye by mitochondria、and photoreaction with DNA have been of interest for decades. Recent applications of this technology to HIV phototherapy have reviewed previous methylene blue literature .、Thiazine dyes are generally of minor importance in the textile field due to what is presently considered as inferior fastness。
次甲基蓝（三水） 是一种化工化合物，登记 CAS 号为 12262-49-6，分子式 C16H18N3S.Cl（分子量 319.9）。
登记 CAS 号：12262-49-6
其分子式 C16H18N3S.Cl 由 16 个碳、18 个氢、3 个氮、1 个硫、1 个氯 组成。
别名/同义词：次甲基蓝（三水） · Solvent Blue 8
次甲基蓝（三水） 的 CAS 登记号为 12262-49-6。
分子式 C16H18N3S.Cl，分子量 319.9。
别名/同义词：次甲基蓝（三水）、Solvent Blue 8。
登记用途：Uses: Used as a stain in bacteriology、a chemical reagent、an antimethemoglobinemic drug、a polymerization inhibitor、and a temporary hair colorant、also used as a paper、textile、and leather dye、[HSDB] Azine dye、[Kirk-Othmer]、Pulp and Paper Processing [Category: Industry]、Textiles (Printing、Dyeing、or Finishing) [Category: Industry]、For methylene blue (USEPA、OPP Pesticide Code: 039505) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Stain in bacteriology、reagent for several chemicals、as mixed indicator、as redox colorimetric agent. Targeting agent for melanoma.、Dyeing cotton and wool、biological and bacteriological stains、reagent in oxidation-reduction titrations in volumetric analysis、indicator、Methylene blue is mainly used to dye paper and office supplies、but also to tone up silk colors. ... as a stain in microscopy、as a hydrogen acceptor in enzymatic dehydrogenations、as a redox indicator in iodometry and titanometry、and as a cosmetic dye.、For more Uses (Complete) data for Methylene blue (8 total)、please visit the HSDB record page.、Use Classification: Cosmetics -> Hair dyeing、Household Products: Information on 1 consumer products that contain Methylene blue in the following categories is provided:、• Commercial、Institutional、Information on 2 consumer products that contain Methylene blue in the following categories is provided:、• Pet Care、Methods of Manufacturing: Methylene blue ... is obtained by oxidation of 4-aminodimethylaniline in the presence of sodium thiosulfate to give the quinonediiminothiosulfonic acid、reaction with dimethylaniline、oxidation to the indamine、and cyclization to give the thiazine. The dye is commercially available as the hydrochloride and as the zinc chloride double salt.、By treating a solution of N、N-dimethyl-p-phenylenediamine and N、N、-dimethylaniline hydrochlorides with H2S and FeCl3 or another suitable oxidizing agent.、By oxidation of p-aminodimethylaniline with ferric chloride in the presence of hydrogen sulfide. The dye is the zinc chloride double salt of the chloride.、N-Dimethyl-p-phenylene diamine ... reacts with sodium thiosulfate ... to form the thiosulfonic acid which condenses with N、N-dimethylaniline ... in the presence of sodium dichromate ... to the indamine、then with copper sulfate ... and sodium dichromate to methylene blue.、Impurities: 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ylium、Formulations、Preparations: Provided technically as the zinc double chloride、used medically in a zinc free form.、Parenteral: Injection、for IV use、10 mg、mL (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name)、Grade: USP、technical.、U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3133]、General Manufacturing Information: Phenothiazin-5-ium、3、7-bis(dimethylamino)-、chloride (1:1): ACTIVE、C16H18N3SCl.3H2O (medicinal)、(C16H18N3SCl)2.ZnCl2H20 (dye)、Methylene blue has also been described as a "photosensitizer" which means that it can absorb light and transfer the absorbed energy to another compound.、Methylene blue was first isolated in 1876. Its use covers many areas、including as an antiseptic、disinfectant、and cyanide-antidote. Methylene blue is also an antimicrobial agent in plastic materials such as food packaging wraps、surgical drapes、face masks、and other film materials. Light exposure of the dye dispersed in plastic generates reactive singlet oxygen、which is the active antimicrobial species. Methylene blue is approved for topical、intravenous、and oral administration. Its cellular adsorption selectivity、subcellular localization、reduction to leuko-dye by mitochondria、and photoreaction with DNA have been of interest for decades. Recent applications of this technology to HIV phototherapy have reviewed previous methylene blue literature .、Thiazine dyes are generally of minor importance in the textile field due to what is presently considered as inferior fastness。
次甲基蓝（三水）（CAS 12262-49-6）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 12262-49-6 |
|---|---|
| PubChem CID | 6099 |
| 分子式 | C16H18N3S.Cl |
| IUPAC 名称 | [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium chloride |
| UNII（FDA） | 8NAP7826UB |
| Molecular Weight | 319.9 |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 319.0909965 |
| Monoisotopic Mass | 319.0909965 |
| Topological Polar Surface Area | 43.9 |
| Heavy Atom Count | 21 |
| Melting Point | 100 |
|---|---|
| Melting Point | 100-110 °C (decomposes) |
| Solubility | In water, 43,600 mg/L at 25 °C. |
| Vapor Pressure | 0.00000013 [mmHg] |
| Color Additive Status | 81.30 |
methylene blue; 61-73-4; Basic blue 9; Methylthioninium chloride; Solvent blue 8; Swiss Blue; C.I. Basic Blue 9; Chromosmon; Methylene Blue anhydrous; Methylene Blue N; Methylene Blue BB; Urolene blue; Methylenium ceruleum; Methylene Blue chloride; Bleu de methylene; Methylene Blue A
| 法规与食品接触 | FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA 21 CFR 中列出的食品接触物质清单：FCS CIR / INCI: Hair dyeing |
|---|---|
| GHS 通报统计 | 8.1% (22 / 273) |
| GHS 通报统计 | 8.1% (22 / 273) |
|---|---|
| 已通报的危害声明 | H302 (91.6%), H318 (25.6%), H412 (10.3%), H361, H370, H372 |
次甲基蓝（三水） · CAS 12262-49-6 · C16H18N3S.Cl. UNII 8NAP7826UB. Melting Point: 100; Melting Point: 100-110 °C (decomposes); Solubility: In water, 43,600 mg/L at 25 °C..
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Solvent Blue 8