Simethicone

Independent reference data for Simethicone (CAS 8050-81-5), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Documented uses on record

The main use of simethicone as an excipient is as an antifoaming agent in pharmaceutical manufacturing processes ... .A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.

Synonyms and trade names

Simethicone; 8050-81-5; Sentry Simethicone; Mylanta Gas Relief; Mylicon Infant's Drops; Sentry Simethicone Emulsion; DTXSID00904918; RefChem:886342; 3,3,5,5-tetramethyl-2,4-dioxa-3,5-disilahexane; silanedione; 617-098-1; dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane; Simethicon; Simethicone(200); Simethicone(500); SIMETICONE; C6H18O4Si3

Regulatory listings held on file

Regulatory & Food Contact	ANTICAKING_AGENT; ANTIFOAMING_AGENT: Food Additives DIMETHYLPOLYSILOXANE 0–1.5 mg/kg bw The Committee withdrew the temporary ADI of 0–0.8 mg/kg body weight per day and re-established the ADI of 0â TRS 966-JECFA 74/27 FAS 60-JECFA 69/165
GHS notification summary	96.6% (86 / 89)

GHS hazard classification

GHS notification summary	96.6% (86 / 89)
Reported hazard statements	H225 (100%), H319 (100%), H335 (100%), H336 (100%)

This chemical does not meet GHS hazard criteria for 96.6% (86 of 89) of all reports.

Reported as not meeting GHS hazard criteria by 86 of 89 companies (only 3.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

What the public record says

POLYDIMETHYLSILOXANE · CAS 8050-81-5 · C6H18O4Si3. UNII SIMETICONE.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.