司美替尼

司美替尼（CAS 606143-52-6）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的记载用途

Selumetinib is indicated for the treatment of neurofibromatosis type 1 (NF1) in adult and pediatric patients one year of age and older who have symptomatic, inoperable plexiform neurofibromas (PN).Selumetinib is an oral, small molecule inhibitor of the mitogen activated protein kinase 1 and 2 (MEK1/2) that is used to treat symptomatic, refractory fibromas in neurofibromatosis type 1. Selumetinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury.

同义词与商品名

Selumetinib; 606143-52-6; AZD6244; ARRY-142886; 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE; AZD 6244; AZD-6244; ARRY-886; selumetinibum; DTXSID3048944; 6UH91I579U; ARRY142886; DTXCID0028870; CHEBI:90227; 1H-Benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-; 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

GHS 危害分类

Reported hazard statements	H302 (40%), H317 (80%), H318 (60%), H361 (80%), H373 (80%), H411 (60%), H413 (20%)

H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]

H317 (80%): May cause an allergic skin reaction [Warning Sensitization, Skin]

公开数据库对它的描述

Selumetinib · CAS 606143-52-6 · C17H15BrClFN4O3. UNII 6UH91I579U.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。