沙拉沙星（CAS 98105-99-8）：分子式 C20H17F2N3O3、分子量 385.4。
| CAS号 | 98105-99-8 |
|---|---|
| 分子式 | C20H17F2N3O3 |
| 分子量 | 385.4 |
| LogP | 0.3 |
| 应用领域 | Uses: MEDICATION (VET)、Use Classification: Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals、Methods of Manufacturing: Condensation of 7-chloro-1-(p-fluorophenyl)-6-fluoro-1、4-dihydro-4-oxoquinoline-3-carboxylic acid with N-carboethoxypiperazine in hot 1-methyl-2-pyrrolidinone yields the N-carboethoxy derivative of A-56620. Hydrolysis of the derivative with sodium hydroxide in aqueous ethanol followed by treatment with dilute hydrochloric acid gives A-56620.、Preparation: D. T. W. Chu、European Patent Office patent 131839、idem、USA patent 4730000 (1985、1988 both to Abbott)、... H. Narita et al.、Japanese patent Kokai 85237069 (1985 to Toyama).、General Manufacturing Information: Patent number U.S. 4、730、000、expired、March 18、2005、Sarafloxacin hydrchloride injection |
登记用途：Uses: MEDICATION (VET)、Use Classification: Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals、Methods of Manufacturing: Condensation of 7-chloro-1-(p-fluorophenyl)-6-fluoro-1、4-dihydro-4-oxoquinoline-3-carboxylic acid with N-carboethoxypiperazine in hot 1-methyl-2-pyrrolidinone yields the N-carboethoxy derivative of A-56620. Hydrolysis of the derivative with sodium hydroxide in aqueous ethanol followed by treatment with dilute hydrochloric acid gives A-56620.、Preparation: D. T. W. Chu、European Patent Office patent 131839、idem、USA patent 4730000 (1985、1988 both to Abbott)、... H. Narita et al.、Japanese patent Kokai 85237069 (1985 to Toyama).、General Manufacturing Information: Patent number U.S. 4、730、000、expired、March 18、2005、Sarafloxacin hydrchloride injection。
沙拉沙星 是一种化工化合物，登记 CAS 号为 98105-99-8，分子式 C20H17F2N3O3（分子量 385.4）。
登记 CAS 号：98105-99-8
其分子式 C20H17F2N3O3 由 20 个碳、17 个氢、2 个氟、3 个氮、3 个氧 组成。
别名/同义词：沙拉沙星 · Sarafloxacin
沙拉沙星 的 CAS 登记号为 98105-99-8。
分子式 C20H17F2N3O3，分子量 385.4。
别名/同义词：沙拉沙星、Sarafloxacin。
登记用途：Uses: MEDICATION (VET)、Use Classification: Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals、Methods of Manufacturing: Condensation of 7-chloro-1-(p-fluorophenyl)-6-fluoro-1、4-dihydro-4-oxoquinoline-3-carboxylic acid with N-carboethoxypiperazine in hot 1-methyl-2-pyrrolidinone yields the N-carboethoxy derivative of A-56620. Hydrolysis of the derivative with sodium hydroxide in aqueous ethanol followed by treatment with dilute hydrochloric acid gives A-56620.、Preparation: D. T. W. Chu、European Patent Office patent 131839、idem、USA patent 4730000 (1985、1988 both to Abbott)、... H. Narita et al.、Japanese patent Kokai 85237069 (1985 to Toyama).、General Manufacturing Information: Patent number U.S. 4、730、000、expired、March 18、2005、Sarafloxacin hydrchloride injection。
沙拉沙星（CAS 98105-99-8）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 98105-99-8 |
|---|---|
| PubChem CID | 56208 |
| Molecular formula | C20H17F2N3O3 |
| IUPAC name | 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid |
| UNII (FDA) | RC3WJ907XY |
| Molecular Weight | 385.4 |
|---|---|
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 3 |
| Exact Mass | 385.12379774 |
| Monoisotopic Mass | 385.12379774 |
| Topological Polar Surface Area | 72.9 |
| Heavy Atom Count | 28 |
| Dissociation Constants | pKa1= 5.6; pKa2 = 8.2 |
|---|---|
| Collision Cross Section | 203.4 Ų [M+Na]+ |
| Collision Cross Section | 187.09 Ų [M+H]+ |
| Collision Cross Section | 202 Ų [M+H]+ |
Sarafloxacin; 98105-99-8; Sarafloxacine; 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; Sarafloxacino; Sarafloxacinum; Difloxacinum [Latin]; DTXSID8048494; 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid; RC3WJ907XY; ABBOTT-57135; 3-Quinolinecarboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-; A-56620; DTXCID4028468; Difloxacinum (Latin); 1-FPFPOC
| Regulatory & Food Contact | ANTIMICROBIAL_AGENT: Veterinary Drug 0-0.33 µg/kg bw TRS 888-JECFA 50/33 FAS 41-JECFA 50/37 |
|---|---|
| GHS notification summary | 100% (3 / 3) |
| GHS notification summary | 100% (3 / 3) |
|---|
This chemical does not meet GHS hazard criteria for 100% (3 of 3) of all reports.
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
Sarafloxacin · CAS 98105-99-8 · C20H17F2N3O3. UNII RC3WJ907XY. Dissociation Constants: pKa1= 5.6; pKa2 = 8.2; Collision Cross Section: 203.4 Ų [M+Na]+; Collision Cross Section: 187.09 Ų [M+H]+.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Sarafloxacin