沙美特罗（CAS 89365-50-4）：分子式 C25H37NO4、分子量 415.6。
| CAS号 | 89365-50-4 |
|---|---|
| 分子式 | C25H37NO4 |
| 分子量 | 415.6 |
| 熔点 | 75.5-76.5 °C |
| 沸点 | 603 |
| LogP | 4.2 |
| 应用领域 | Uses: Anti-asthmatic、Xinafoate salt、Bronchodilator、MEDICATION、Salmeterol ...、is、indicated as bronchodilators for the treatment of bronchospasm associated with chronic obstructive airway disease、including bronchitis and pulmonary emphysema. ...、Included in US product labeling、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 67800、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.24、Calculated removal (%): 73.4、For the treatment of asthma and chronic obstructive pulmonary disease (COPD).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Preparation: I.F. Skidmore et al.、DE 3414752、eidem US 4992474 (1984、1991 both to Glaxo)、Formulations、Preparations: Oral Inhalation: Aerosol 21 ug (of salmeterol) per metered spray (from the actuator) Serevent ( with fluorochlorohydrocarbon propellants)、(GlaxoSmithKline)、Powder: 50 ug (of salmeterol) per inhalation Serevent Diskus、(GlaxoSmithKline).、Salmeterol xinafoate、Oral Inhalation: Powder 50 ug (of salmeterol) with fluticasone propionate 100、250、or 500 ug per inhalation- Advair (GlaxoSmithKline).、Salmeterol xinafoate combinations、General Manufacturing Information: Structural analog of albuterol.、Information available in 2005 indicated that Salmeterol was used in the manufacture of pharmaceutical preparations in the following countries: Antigua & Barbuda、Aruba、Bahrain、Barbados、Chile、Croatia、Grenada、Guyana、India、Iran、Jamaica、Kuwait、Luxembourg、Netherlands Antilles、Oman、Qatar、Saint Lucia、Saint Vincent & The Grenadines、Slovenia、Turkey、Trinidad & Tobago、United Arab Emirates、Yugoslavia (1、2)、Information available in 2005 indicated that Salmeterol xinafoate was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Australia、Austria、Bangladesh、Belgium、Brazil、Bulgaria、Canada、Costa Rica、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Honduras、Hong Kong、Hungary、Indonesia、Ireland、Israel、Italy、Malaysia、Mexico、Netherlands、New Zealand、Nicaragua、Norway、Panama、Poland、Portugal、Romania、Russian Federation、Singapore、South Africa、Spain、Sweden、Switzerland、Thailand、United Kingdom、United States (1 |
登记用途：Uses: Anti-asthmatic、Xinafoate salt、Bronchodilator、MEDICATION、Salmeterol ...、is、indicated as bronchodilators for the treatment of bronchospasm associated with chronic obstructive airway disease、including bronchitis and pulmonary emphysema. ...、Included in US product labeling、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 67800、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.24、Calculated removal (%): 73.4、For the treatment of asthma and chronic obstructive pulmonary disease (COPD).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Preparation: I.F. Skidmore et al.、DE 3414752、eidem US 4992474 (1984、1991 both to Glaxo)、Formulations、Preparations: Oral Inhalation: Aerosol 21 ug (of salmeterol) per metered spray (from the actuator) Serevent ( with fluorochlorohydrocarbon propellants)、(GlaxoSmithKline)、Powder: 50 ug (of salmeterol) per inhalation Serevent Diskus、(GlaxoSmithKline).、Salmeterol xinafoate、Oral Inhalation: Powder 50 ug (of salmeterol) with fluticasone propionate 100、250、or 500 ug per inhalation- Advair (GlaxoSmithKline).、Salmeterol xinafoate combinations、General Manufacturing Information: Structural analog of albuterol.、Information available in 2005 indicated that Salmeterol was used in the manufacture of pharmaceutical preparations in the following countries: Antigua & Barbuda、Aruba、Bahrain、Barbados、Chile、Croatia、Grenada、Guyana、India、Iran、Jamaica、Kuwait、Luxembourg、Netherlands Antilles、Oman、Qatar、Saint Lucia、Saint Vincent & The Grenadines、Slovenia、Turkey、Trinidad & Tobago、United Arab Emirates、Yugoslavia (1、2)、Information available in 2005 indicated that Salmeterol xinafoate was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Australia、Austria、Bangladesh、Belgium、Brazil、Bulgaria、Canada、Costa Rica、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Honduras、Hong Kong、Hungary、Indonesia、Ireland、Israel、Italy、Malaysia、Mexico、Netherlands、New Zealand、Nicaragua、Norway、Panama、Poland、Portugal、Romania、Russian Federation、Singapore、South Africa、Spain、Sweden、Switzerland、Thailand、United Kingdom、United States (1。
沙美特罗 是一种化工化合物，登记 CAS 号为 89365-50-4，分子式 C25H37NO4（分子量 415.6）。
登记 CAS 号：89365-50-4
其分子式 C25H37NO4 由 25 个碳、37 个氢、1 个氮、4 个氧 组成。
别名/同义词：沙美特罗 · Salmeterol
沙美特罗 的 CAS 登记号为 89365-50-4。
分子式 C25H37NO4，分子量 415.6。
别名/同义词：沙美特罗、Salmeterol。
登记用途：Uses: Anti-asthmatic、Xinafoate salt、Bronchodilator、MEDICATION、Salmeterol ...、is、indicated as bronchodilators for the treatment of bronchospasm associated with chronic obstructive airway disease、including bronchitis and pulmonary emphysema. ...、Included in US product labeling、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 67800、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.24、Calculated removal (%): 73.4、For the treatment of asthma and chronic obstructive pulmonary disease (COPD).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Preparation: I.F. Skidmore et al.、DE 3414752、eidem US 4992474 (1984、1991 both to Glaxo)、Formulations、Preparations: Oral Inhalation: Aerosol 21 ug (of salmeterol) per metered spray (from the actuator) Serevent ( with fluorochlorohydrocarbon propellants)、(GlaxoSmithKline)、Powder: 50 ug (of salmeterol) per inhalation Serevent Diskus、(GlaxoSmithKline).、Salmeterol xinafoate、Oral Inhalation: Powder 50 ug (of salmeterol) with fluticasone propionate 100、250、or 500 ug per inhalation- Advair (GlaxoSmithKline).、Salmeterol xinafoate combinations、General Manufacturing Information: Structural analog of albuterol.、Information available in 2005 indicated that Salmeterol was used in the manufacture of pharmaceutical preparations in the following countries: Antigua & Barbuda、Aruba、Bahrain、Barbados、Chile、Croatia、Grenada、Guyana、India、Iran、Jamaica、Kuwait、Luxembourg、Netherlands Antilles、Oman、Qatar、Saint Lucia、Saint Vincent & The Grenadines、Slovenia、Turkey、Trinidad & Tobago、United Arab Emirates、Yugoslavia (1、2)、Information available in 2005 indicated that Salmeterol xinafoate was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Australia、Austria、Bangladesh、Belgium、Brazil、Bulgaria、Canada、Costa Rica、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Honduras、Hong Kong、Hungary、Indonesia、Ireland、Israel、Italy、Malaysia、Mexico、Netherlands、New Zealand、Nicaragua、Norway、Panama、Poland、Portugal、Romania、Russian Federation、Singapore、South Africa、Spain、Sweden、Switzerland、Thailand、United Kingdom、United States (1。
沙美特罗（CAS 89365-50-4）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 89365-50-4 |
|---|---|
| PubChem CID | 5152 |
| Molecular formula | C25H37NO4 |
| IUPAC name | 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol |
| UNII (FDA) | 2I4BC502BT |
| Molecular Weight | 415.6 |
|---|---|
| XLogP3 | 3.9 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 16 |
| Exact Mass | 415.27225866 |
| Monoisotopic Mass | 415.27225866 |
| Topological Polar Surface Area | 82 |
| Heavy Atom Count | 30 |
| Boiling Point | 603 |
|---|---|
| Melting Point | 75.5-76.5 °C |
| Melting Point | 75.7-76.5 °C |
| Melting Point | 75.5 - 76.5 °C |
| Solubility | 2.26e-03 g/L |
| LogP | 4.2 |
Salmeterol; 89365-50-4; 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol; Salmeterolum; GR 33343X; SALMATEROL; SN408D; DTXSID6023571; GR 33343 X; 2I4BC502BT; GR-33343-X; DTXCID803571; 4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol; 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol; Neovent; Soltel
| Reported hazard statements | H302 (50%), H315 (100%), H317 (50%), H319 (100%), H412 (50%) |
|---|
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Salmeterol · CAS 89365-50-4 · C25H37NO4. UNII 2I4BC502BT. Boiling Point: 603; Melting Point: 75.5-76.5 °C; Melting Point: 75.7-76.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Salmeterol