沙丁胺醇游离碱（CAS 18559-94-9）：分子式 C13H21NO3、分子量 239.31。
| CAS号 | 18559-94-9 |
|---|---|
| 分子式 | C13H21NO3 |
| 分子量 | 239.31 |
| 熔点 | 147-149 |
| LogP | 1.4 |
| 应用领域 | Uses: Bronchodilator、tocolytic、Medication、Medication (Vet)、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 1781、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Consumption (g per capita) in the USA (2002): 0.00631、Calculated removal (%): 75.1、For symptomatic relief and prevention of bronchospasm due to bronchial asthma、chronic bronchitis、and other chronic bronchopulmonary disorders such as COPD.、Use Classification: Pharmaceuticals、Formulations、Preparations: Oral Inhalation: Aerosol: 90 ug、metered spray Proventil Inhalation Aerosol (with chlorofluorohydrocarbon propellants and oleic acid)、(Schering)、Ventolin Inhalation Aerosol (with chlorofluorohydrocarbon propellants and oleic acid)、(GlaxoSmithKline).、Oral: Solution 2 mg (of albuterol) per 5 mL Proventil Syrup (Schering). Tablets: 2 mg (of albuterol) Proventil (scored)、4 mg (of albuterol) Proventil (scored)、Ventolin (scored)、(GlaxoSmithKline). Tablets、extended release: 4 mg (of albuterol) Volmax (with povidone)、(Muro)、Vospire ER (Odyssey)、8 mg (of albuterol) Volmax (with povidone)、Vospire ER (Odyssey). Tablets、extended-release core、film-coated: 4 mg (core 2 mg with 2 mg immediate release) (of albuterol) Proventil Repetabs (with butylparaben)、(Schering).、Albuterol Sulfate、Oral Inhalation: Aerosol: 90 ug (of albuterol) per metered spray Proventil HFA (with alcohol、hydrofluoroalkane propellant、and oleic acid)、Ventolin HFA (with hydrofluoroalkane propellant)、(GlaxoSmithKline)、Solution、for nebulization: 0.21 mg (of albuterol) per mL (0.63 mg) AccuNeb (preservative-free、available as polyethylene vials)、(Dey)、0.42 mg (of albuterol) per mL (1.25 mg) AccuNeb (preservative-free、0.083% (of albuterol) Albuterol Albuterol Sulfate Inhalation Solution (Dey)、Proventil (preservative-free)、(Schering). Solution、concentrate、for nebulization: 0.5% (of Albuterol) Albuterol Sulfate Inhalation Solution (with benzalkonium chloride)、(Warrick)、Proventil (with benzalkonium chloride)、General Manufacturing Information: Preparation: LHC Lunts et al、ZA 6705591、US 3644353 (1968、1972 both to Allen & Hanburys) |
登记用途：Uses: Bronchodilator、tocolytic、Medication、Medication (Vet)、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 1781、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Consumption (g per capita) in the USA (2002): 0.00631、Calculated removal (%): 75.1、For symptomatic relief and prevention of bronchospasm due to bronchial asthma、chronic bronchitis、and other chronic bronchopulmonary disorders such as COPD.、Use Classification: Pharmaceuticals、Formulations、Preparations: Oral Inhalation: Aerosol: 90 ug、metered spray Proventil Inhalation Aerosol (with chlorofluorohydrocarbon propellants and oleic acid)、(Schering)、Ventolin Inhalation Aerosol (with chlorofluorohydrocarbon propellants and oleic acid)、(GlaxoSmithKline).、Oral: Solution 2 mg (of albuterol) per 5 mL Proventil Syrup (Schering). Tablets: 2 mg (of albuterol) Proventil (scored)、4 mg (of albuterol) Proventil (scored)、Ventolin (scored)、(GlaxoSmithKline). Tablets、extended release: 4 mg (of albuterol) Volmax (with povidone)、(Muro)、Vospire ER (Odyssey)、8 mg (of albuterol) Volmax (with povidone)、Vospire ER (Odyssey). Tablets、extended-release core、film-coated: 4 mg (core 2 mg with 2 mg immediate release) (of albuterol) Proventil Repetabs (with butylparaben)、(Schering).、Albuterol Sulfate、Oral Inhalation: Aerosol: 90 ug (of albuterol) per metered spray Proventil HFA (with alcohol、hydrofluoroalkane propellant、and oleic acid)、Ventolin HFA (with hydrofluoroalkane propellant)、(GlaxoSmithKline)、Solution、for nebulization: 0.21 mg (of albuterol) per mL (0.63 mg) AccuNeb (preservative-free、available as polyethylene vials)、(Dey)、0.42 mg (of albuterol) per mL (1.25 mg) AccuNeb (preservative-free、0.083% (of albuterol) Albuterol Albuterol Sulfate Inhalation Solution (Dey)、Proventil (preservative-free)、(Schering). Solution、concentrate、for nebulization: 0.5% (of Albuterol) Albuterol Sulfate Inhalation Solution (with benzalkonium chloride)、(Warrick)、Proventil (with benzalkonium chloride)、General Manufacturing Information: Preparation: LHC Lunts et al、ZA 6705591、US 3644353 (1968、1972 both to Allen & Hanburys)。
沙丁胺醇游离碱 是一种化工化合物，登记 CAS 号为 18559-94-9，分子式 C13H21NO3（分子量 239.31）。
登记 CAS 号：18559-94-9
其分子式 C13H21NO3 由 13 个碳、21 个氢、1 个氮、3 个氧 组成。
别名/同义词：沙丁胺醇游离碱 · salbutamol free base
沙丁胺醇游离碱 的 CAS 登记号为 18559-94-9。
分子式 C13H21NO3，分子量 239.31。
别名/同义词：沙丁胺醇游离碱、salbutamol free base。
登记用途：Uses: Bronchodilator、tocolytic、Medication、Medication (Vet)、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 1781、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Consumption (g per capita) in the USA (2002): 0.00631、Calculated removal (%): 75.1、For symptomatic relief and prevention of bronchospasm due to bronchial asthma、chronic bronchitis、and other chronic bronchopulmonary disorders such as COPD.、Use Classification: Pharmaceuticals、Formulations、Preparations: Oral Inhalation: Aerosol: 90 ug、metered spray Proventil Inhalation Aerosol (with chlorofluorohydrocarbon propellants and oleic acid)、(Schering)、Ventolin Inhalation Aerosol (with chlorofluorohydrocarbon propellants and oleic acid)、(GlaxoSmithKline).、Oral: Solution 2 mg (of albuterol) per 5 mL Proventil Syrup (Schering). Tablets: 2 mg (of albuterol) Proventil (scored)、4 mg (of albuterol) Proventil (scored)、Ventolin (scored)、(GlaxoSmithKline). Tablets、extended release: 4 mg (of albuterol) Volmax (with povidone)、(Muro)、Vospire ER (Odyssey)、8 mg (of albuterol) Volmax (with povidone)、Vospire ER (Odyssey). Tablets、extended-release core、film-coated: 4 mg (core 2 mg with 2 mg immediate release) (of albuterol) Proventil Repetabs (with butylparaben)、(Schering).、Albuterol Sulfate、Oral Inhalation: Aerosol: 90 ug (of albuterol) per metered spray Proventil HFA (with alcohol、hydrofluoroalkane propellant、and oleic acid)、Ventolin HFA (with hydrofluoroalkane propellant)、(GlaxoSmithKline)、Solution、for nebulization: 0.21 mg (of albuterol) per mL (0.63 mg) AccuNeb (preservative-free、available as polyethylene vials)、(Dey)、0.42 mg (of albuterol) per mL (1.25 mg) AccuNeb (preservative-free、0.083% (of albuterol) Albuterol Albuterol Sulfate Inhalation Solution (Dey)、Proventil (preservative-free)、(Schering). Solution、concentrate、for nebulization: 0.5% (of Albuterol) Albuterol Sulfate Inhalation Solution (with benzalkonium chloride)、(Warrick)、Proventil (with benzalkonium chloride)、General Manufacturing Information: Preparation: LHC Lunts et al、ZA 6705591、US 3644353 (1968、1972 both to Allen & Hanburys)。
沙丁胺醇游离碱（CAS 18559-94-9）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 18559-94-9 |
|---|---|
| PubChem CID | 2083 |
| Molecular formula | C13H21NO3 |
| IUPAC name | 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol |
| UNII (FDA) | QF8SVZ843E |
| Molecular Weight | 239.31 |
|---|---|
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 239.15214353 |
| Monoisotopic Mass | 239.15214353 |
| Topological Polar Surface Area | 72.7 |
| Heavy Atom Count | 17 |
| Melting Point | 147-149 |
|---|---|
| Melting Point | 151 °C (Lunts); 157-158 °C (Collins) |
| Melting Point | 157 - 158 °C |
| Solubility | 14100 |
| Solubility | 2.15e+00 g/L |
| LogP | 1.4 |
| LogP | -0.39 |
| Dissociation Constants | 10.3 |
| Collision Cross Section | 159.93 Ų [M+H]+ |
| Collision Cross Section | 166.6 Ų [M-H]- |
Salbutamol; albuterol; 18559-94-9; Ventoline; Aerolin; Proventil HFA; Salbutamolum; Asthalin; Cobutolin; Salbuvent; Asmaven; Salamol; Asmol; 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; Ventilan; Ventodisks
| Reported hazard statements | H302 (98%), H317 (11.8%) |
|---|
H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
H317 (11.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]
salbutamol free base · CAS 18559-94-9 · C13H21NO3. UNII QF8SVZ843E. Melting Point: 147-149; Melting Point: 151 °C (Lunts); 157-158 °C (Collins); Melting Point: 157 - 158 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: salbutamol free base