罗匹尼罗（CAS 91374-21-9）：分子式 C16H24N2O、分子量 260.37。
| CAS号 | 91374-21-9 |
|---|---|
| 分子式 | C16H24N2O |
| 分子量 | 260.37 |
| 熔点 | 243-250 °C |
| 沸点 | 410.5±45.0 °C at 760 mmHg |
| LogP | 3.06 |
| 应用领域 | Uses: MEDICATION、Antiparkinson Agents、Dopamine Agonists、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 11.8、For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: The acid chloride of 2-(2-methyl-3-nitrophenyl)acetic acid is prepared with thionyl chloride、then treated with dipropylamine to form the amide. The carbonyl group is reduced with borane in THF and then reacted with diethyl oxalate and sodium in alcohol in a Claisen-type reaction to produce the ethyl ester of 3-[[2-(dipropylamino)ethyl]-6-nitrophenyl]pyruvic acid. Hydrolysis and decarboxylation of the acid with peroxide and base removes the ethoxycarbonyl group and forms 2-[2-(dipropylamino)ethyl]-6-nitrophenylacetic acid. Cyclization to the product is effected by catalytic reduction of the nitro group、using palladium、hydrogen to give the amine、which through loss of water forms the lactam (indolone). Heating with HCl forms ...、ropinirole hydrochloride、.、Ropinirole hydrochloride、Preparation: G. Gallagher、Jr.、United States of America patent 4452808 (1984 to SmithKline Beckman)、Formulations、Preparations: Table: Ropinirole Hydrochloride Preparations [Table#8233] |
登记用途：Uses: MEDICATION、Antiparkinson Agents、Dopamine Agonists、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 11.8、For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: The acid chloride of 2-(2-methyl-3-nitrophenyl)acetic acid is prepared with thionyl chloride、then treated with dipropylamine to form the amide. The carbonyl group is reduced with borane in THF and then reacted with diethyl oxalate and sodium in alcohol in a Claisen-type reaction to produce the ethyl ester of 3-[[2-(dipropylamino)ethyl]-6-nitrophenyl]pyruvic acid. Hydrolysis and decarboxylation of the acid with peroxide and base removes the ethoxycarbonyl group and forms 2-[2-(dipropylamino)ethyl]-6-nitrophenylacetic acid. Cyclization to the product is effected by catalytic reduction of the nitro group、using palladium、hydrogen to give the amine、which through loss of water forms the lactam (indolone). Heating with HCl forms ...、ropinirole hydrochloride、.、Ropinirole hydrochloride、Preparation: G. Gallagher、Jr.、United States of America patent 4452808 (1984 to SmithKline Beckman)、Formulations、Preparations: Table: Ropinirole Hydrochloride Preparations [Table#8233]。
罗匹尼罗 是一种化工化合物，登记 CAS 号为 91374-21-9，分子式 C16H24N2O（分子量 260.37）。
登记 CAS 号：91374-21-9
其分子式 C16H24N2O 由 16 个碳、24 个氢、2 个氮、1 个氧 组成。
别名/同义词：罗匹尼罗 · Ropinirole
罗匹尼罗 的 CAS 登记号为 91374-21-9。
分子式 C16H24N2O，分子量 260.37。
别名/同义词：罗匹尼罗、Ropinirole。
登记用途：Uses: MEDICATION、Antiparkinson Agents、Dopamine Agonists、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 11.8、For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: The acid chloride of 2-(2-methyl-3-nitrophenyl)acetic acid is prepared with thionyl chloride、then treated with dipropylamine to form the amide. The carbonyl group is reduced with borane in THF and then reacted with diethyl oxalate and sodium in alcohol in a Claisen-type reaction to produce the ethyl ester of 3-[[2-(dipropylamino)ethyl]-6-nitrophenyl]pyruvic acid. Hydrolysis and decarboxylation of the acid with peroxide and base removes the ethoxycarbonyl group and forms 2-[2-(dipropylamino)ethyl]-6-nitrophenylacetic acid. Cyclization to the product is effected by catalytic reduction of the nitro group、using palladium、hydrogen to give the amine、which through loss of water forms the lactam (indolone). Heating with HCl forms ...、ropinirole hydrochloride、.、Ropinirole hydrochloride、Preparation: G. Gallagher、Jr.、United States of America patent 4452808 (1984 to SmithKline Beckman)、Formulations、Preparations: Table: Ropinirole Hydrochloride Preparations [Table#8233]。
罗匹尼罗（CAS 91374-21-9）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 91374-21-9 |
|---|---|
| PubChem CID | 5095 |
| Molecular formula | C16H24N2O |
| IUPAC name | 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one |
| UNII (FDA) | 030PYR8953 |
| Molecular Weight | 260.37 |
|---|---|
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 7 |
| Exact Mass | 260.188863393 |
| Monoisotopic Mass | 260.188863393 |
| Topological Polar Surface Area | 32.3 |
| Heavy Atom Count | 19 |
| Boiling Point | 410.5±45.0 °C at 760 mmHg |
|---|---|
| Melting Point | 243-250 °C |
| Melting Point | 243 - 250 °C |
| Solubility | 133 |
| Solubility | 3.53e-01 g/L |
| LogP | 3.06 |
| LogP | log Kow = 2.70 |
| LogP | 2.3 |
| LogP | 2.84 |
| Dissociation Constants | 10.17 |
ropinirole; 91374-21-9; ropinirol; Ropinirolum; Ropitor; SKF 101468; SK&F 101468; Narapin; DTXSID8045195; 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; NSC-758917; 030PYR8953; SK&F-101468; CHEBI:8888; DTXCID6025195; Adartrel
| Reported hazard statements | H302 (100%), H412 (100%), H400, H410 |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
Ropinirole · CAS 91374-21-9 · C16H24N2O. UNII 030PYR8953. Boiling Point: 410.5±45.0 °C at 760 mmHg; Melting Point: 243-250 °C; Melting Point: 243 - 250 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Ropinirole