利培酮（CAS 106266-06-2）：分子式 C23H27FN4O2、分子量 410.5。
| CAS号 | 106266-06-2 |
|---|---|
| 分子式 | C23H27FN4O2 |
| 分子量 | 410.5 |
| 熔点 | 170 |
| 沸点 | 442 |
| LogP | 2.86 |
| 应用领域 | Uses: Antipsychotic Agents、Dopamine Antagonists、Serotonin Antagonists、MEDICATION、Use (kg、approx.) in Germany (2009): >100、Use (kg) in USA (2002): 458、Consumption (g per capita、approx.) in Germany (2009): 0.00122、Consumption (g per capita) in the USA (2002): 0.00162、Calculated removal (%): 12.8、For the treatment of schizophrenia in adults and in adolescents、ages 13 to 17、and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and、or psychosis in patients with severe dementia.、Use Classification: Pharmaceuticals、Methods of Manufacturing: A Friedel-Crafts condensation of 1-acetylpiperidone-4-carbonyl chloride and 2、4-difluorobenzene、followed by hydrolysis of the N-acetyl group yields 4-(2、4-difluorobenzoyl)piperidone and the benzoyl carbonyl is converted to the oxime. With alkali、the fluorine atom in the 2-position is displaced through ring closure to form the isoxazole moiety. The secondary amine of the piperidine ring is alkylated with 3-(2-chloroethyl)pyridol[1、2-a]pyrimidin-4-one to yield the product.、Preparation: L. E. J. Kennis、J. Vandenberk、European Patent Office 196132、eidem、United States of America patent 4804663 (1986、1989 both to Janssen)、Impurities: 3-[2-[4-[(E)-(2、4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6、7、8、9-tetrahydro-4H-pyrido[1、2-a]pyrimidin-4-one、3-[2-[4-[(Z)-(2、(9RS)-3-[2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6、3-[2-[4-(5-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6、(6RS)-3-[2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2、6-dimethyl-6、2-[2-methyl-4-oxo-6、2-a]pyrimidin-3-yl]ethyl 4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidine-1-carboxylate、3-[2-[4-(2、4-difluorobenzoyl)piperidin-1-yl]ethyl]-2-methyl-6、3-[2-[4-[4-fluoro-2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidine-1-yl]benzoyl]piperidin-1-yl]ethyl]-2-methyl-6、Formulations、Preparations: Table: Risperidone Preparations [Table#7275]、Table: Risperidone Preparations [Table#7276] |
登记用途：Uses: Antipsychotic Agents、Dopamine Antagonists、Serotonin Antagonists、MEDICATION、Use (kg、approx.) in Germany (2009): >100、Use (kg) in USA (2002): 458、Consumption (g per capita、approx.) in Germany (2009): 0.00122、Consumption (g per capita) in the USA (2002): 0.00162、Calculated removal (%): 12.8、For the treatment of schizophrenia in adults and in adolescents、ages 13 to 17、and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and、or psychosis in patients with severe dementia.、Use Classification: Pharmaceuticals、Methods of Manufacturing: A Friedel-Crafts condensation of 1-acetylpiperidone-4-carbonyl chloride and 2、4-difluorobenzene、followed by hydrolysis of the N-acetyl group yields 4-(2、4-difluorobenzoyl)piperidone and the benzoyl carbonyl is converted to the oxime. With alkali、the fluorine atom in the 2-position is displaced through ring closure to form the isoxazole moiety. The secondary amine of the piperidine ring is alkylated with 3-(2-chloroethyl)pyridol[1、2-a]pyrimidin-4-one to yield the product.、Preparation: L. E. J. Kennis、J. Vandenberk、European Patent Office 196132、eidem、United States of America patent 4804663 (1986、1989 both to Janssen)、Impurities: 3-[2-[4-[(E)-(2、4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6、7、8、9-tetrahydro-4H-pyrido[1、2-a]pyrimidin-4-one、3-[2-[4-[(Z)-(2、(9RS)-3-[2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6、3-[2-[4-(5-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6、(6RS)-3-[2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2、6-dimethyl-6、2-[2-methyl-4-oxo-6、2-a]pyrimidin-3-yl]ethyl 4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidine-1-carboxylate、3-[2-[4-(2、4-difluorobenzoyl)piperidin-1-yl]ethyl]-2-methyl-6、3-[2-[4-[4-fluoro-2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidine-1-yl]benzoyl]piperidin-1-yl]ethyl]-2-methyl-6、Formulations、Preparations: Table: Risperidone Preparations [Table#7275]、Table: Risperidone Preparations [Table#7276]。
利培酮 是一种化工化合物，登记 CAS 号为 106266-06-2，分子式 C23H27FN4O2（分子量 410.5）。
登记 CAS 号：106266-06-2
其分子式 C23H27FN4O2 由 23 个碳、27 个氢、1 个氟、4 个氮、2 个氧 组成。
别名/同义词：利培酮 · Risperidone
利培酮 的 CAS 登记号为 106266-06-2。
分子式 C23H27FN4O2，分子量 410.5。
别名/同义词：利培酮、Risperidone。
登记用途：Uses: Antipsychotic Agents、Dopamine Antagonists、Serotonin Antagonists、MEDICATION、Use (kg、approx.) in Germany (2009): >100、Use (kg) in USA (2002): 458、Consumption (g per capita、approx.) in Germany (2009): 0.00122、Consumption (g per capita) in the USA (2002): 0.00162、Calculated removal (%): 12.8、For the treatment of schizophrenia in adults and in adolescents、ages 13 to 17、and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and、or psychosis in patients with severe dementia.、Use Classification: Pharmaceuticals、Methods of Manufacturing: A Friedel-Crafts condensation of 1-acetylpiperidone-4-carbonyl chloride and 2、4-difluorobenzene、followed by hydrolysis of the N-acetyl group yields 4-(2、4-difluorobenzoyl)piperidone and the benzoyl carbonyl is converted to the oxime. With alkali、the fluorine atom in the 2-position is displaced through ring closure to form the isoxazole moiety. The secondary amine of the piperidine ring is alkylated with 3-(2-chloroethyl)pyridol[1、2-a]pyrimidin-4-one to yield the product.、Preparation: L. E. J. Kennis、J. Vandenberk、European Patent Office 196132、eidem、United States of America patent 4804663 (1986、1989 both to Janssen)、Impurities: 3-[2-[4-[(E)-(2、4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6、7、8、9-tetrahydro-4H-pyrido[1、2-a]pyrimidin-4-one、3-[2-[4-[(Z)-(2、(9RS)-3-[2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6、3-[2-[4-(5-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6、(6RS)-3-[2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2、6-dimethyl-6、2-[2-methyl-4-oxo-6、2-a]pyrimidin-3-yl]ethyl 4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidine-1-carboxylate、3-[2-[4-(2、4-difluorobenzoyl)piperidin-1-yl]ethyl]-2-methyl-6、3-[2-[4-[4-fluoro-2-[4-(6-fluoro-1、2-benzisoxazol-3-yl)piperidine-1-yl]benzoyl]piperidin-1-yl]ethyl]-2-methyl-6、Formulations、Preparations: Table: Risperidone Preparations [Table#7275]、Table: Risperidone Preparations [Table#7276]。
利培酮（CAS 106266-06-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 106266-06-2 |
|---|---|
| PubChem CID | 5073 |
| Molecular formula | C23H27FN4O2 |
| IUPAC name | 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one |
| UNII (FDA) | L6UH7ZF8HC |
| Molecular Weight | 410.5 |
|---|---|
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 410.21180428 |
| Monoisotopic Mass | 410.21180428 |
| Topological Polar Surface Area | 61.9 |
| Heavy Atom Count | 30 |
| Boiling Point | 442 |
|---|---|
| Melting Point | 170 |
| Melting Point | 170 °C |
| Solubility | 2.33 |
| LogP | 2.86 |
| Dissociation Constants | 8.3 |
| Collision Cross Section | 205.77 Ų [M+H]+ |
risperidone; 106266-06-2; Risperdal; Risperdal Consta; Rispolept; Rispolin; Risperin; Sequinan; Risperidona; Risperidal M-Tab; Risperidonum; Risperdal M-Tab; Spiron; Perseris; R 64 766; R-64766
| Reported hazard statements | H301 (99.3%), H331 (12.3%), H351 (12.3%), H411 (19.2%) |
|---|
H301 (99.3%): Toxic if swallowed [Danger Acute toxicity, oral]
H331 (12.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]
Risperidone · CAS 106266-06-2 · C23H27FN4O2. UNII L6UH7ZF8HC. Boiling Point: 442; Melting Point: 170; Melting Point: 170 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Risperidone