Risperidone

Description

Risperidone · CAS 106266-06-2 · C23H27FN4O2. UNII L6UH7ZF8HC. Boiling Point: 442; Melting Point: 170; Melting Point: 170 °C.

Identification

CAS Registry Number	106266-06-2
PubChem CID	5073
Molecular formula	C23H27FN4O2
IUPAC name	3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
UNII (FDA)	L6UH7ZF8HC

Computed Descriptors

Molecular Weight	410.5
XLogP3	2.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	410.21180428
Monoisotopic Mass	410.21180428
Topological Polar Surface Area	61.9
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Boiling Point	442
Melting Point	170
Melting Point	170 °C
Solubility	2.33
LogP	2.86
Dissociation Constants	8.3
Collision Cross Section	205.77 Ų [M+H]+

Physical description & handling notes

• Solid
• White to slightly beige powder
• Crystals from dimethylformamide + propanol
• Soluble in methylene chloride; sparingly soluble in alcohol; practically insoluble in water
• Practically insoluble in water, freely soluble in methylene chloride and soluble in methanol and 0.1N hydrochloric acid
• Stable under recommended storage conditions.

GHS Hazard Classification

Reported hazard statements	H301 (99.3%), H331 (12.3%), H351 (12.3%), H411 (19.2%)

Documented Uses

• Antipsychotic Agents; Dopamine Antagonists; Serotonin Antagonists
• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Consumption (g per capita) in the USA (2002): 0.00162
• For the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and/or psychosis in patients with severe dementia.
• A Friedel-Crafts condensation of 1-acetylpiperidone-4-carbonyl chloride and 2,4-difluorobenzene, followed by hydrolysis of the N-acetyl group yields 4-(2,4-difluorobenzoyl)piperidone and the benzoyl carbonyl is converted to the oxime. With alkali, the fluorine atom in the 2-position is displaced through ring closure to form the isoxazole moiety. The secondary amine of the piperidine ring is alkylated with 3-(2-chloroethyl)pyridol[1,2-a]pyrimidin-4-one to yield the product.

Synonyms

risperidone; 106266-06-2; Risperdal; Risperdal Consta; Rispolept; Rispolin; Risperin; Sequinan; Risperidona; Risperidal M-Tab; Risperidonum; Risperdal M-Tab; Spiron; Perseris; R 64 766; R-64766

Frequently Asked Questions

What are the CAS number and molecular formula of Risperidone?

CAS 106266-06-2; molecular formula C23H27FN4O2; molecular weight — g/mol.

What other names is Risperidone known by?

risperidone, 106266-06-2, Risperdal, Risperdal Consta, Rispolept, Rispolin.

Is Risperidone classified as hazardous?

Hazard statements reported: H301, H331, H351, H411.

What are the key physical properties of Risperidone?

Boiling Point: 442; Melting Point: 170; Melting Point: 170 °C; Solubility: 2.33.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.