核黄素5'-（磷酸二氢盐）

Description

Riboflavin 5'-(dihydrogen phosphate) · CAS 146-17-8 · C17H21N4O9P. UNII 7N464URE7E. Melting Point: 290 °C; Solubility: 92 mg/mL; Collision Cross Section: 200.2 Ų [M+H]+.

Identification

CAS Registry Number	146-17-8
PubChem CID	643976
Molecular formula	C17H21N4O9P
IUPAC name	[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate
UNII (FDA)	7N464URE7E

Computed Descriptors

Molecular Weight	456.3
XLogP3	-2.6
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	456.10461526
Monoisotopic Mass	456.10461526
Topological Polar Surface Area	202
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Melting Point	290 °C
Solubility	92 mg/mL
Collision Cross Section	200.2 Ų [M+H]+
Collision Cross Section	209.3 Ų [M+Na]+
Collision Cross Section	200.1 Ų [M-H]-

Physical description & handling notes

• Solid
• 194.92 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 199.1 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 201.48 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
• 210.66 Ų [M+Na]+ [CCS Type: DT; Method: stepped-field]
• 200.77 Ų [M-H]- [CCS Type: DT; Method: stepped-field]

Regulatory Status

Regulatory & Food Contact	FDA Substance added to food: NUTRIENT SUPPLEMENT

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Administered systemically, flavin mononucleotide is primarily indicated for the treatment of riboflavin deficiency in a variety of contexts (e.g. anemia). It is also used off-label for the prophylaxis of migraine headaches. A topical ophthalmic preparation of flavin mononucleotide, Epioxa, is indicated as a photoenhancer for use in epithelium-on corneal collagen cross-linking for the treatment of keratoconus in adults and pediatric patients aged 13 years and older.
• Avoid alcohol. Ingesting alcohol may reduce the absorption of FMN.
• A group of water-soluble vitamins, some of which are COENZYMES.
• Mechanisms of Action [MoA] - Photoabsorption

Synonyms

flavin mononucleotide; 146-17-8; Vitamin B2 phosphate; Riboflavin 5'-phosphate; Riboflavin 5'-monophosphate; Riboflavin 5'-(dihydrogen phosphate); Riboflavine dihydrogen phosphate; E101a; 7N464URE7E; CHEBI:17621; [(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate; CHEMBL1201794; ((2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo(g)pteridin-10-yl)-2,3,4-trihydroxypentyl) dihydrogen phosphate; Riboflavin, 5'-(dihydrogen phosphate); Mononucleotide, Flavin; RefChem:599273

Frequently Asked Questions

What are the CAS number and molecular formula of Riboflavin 5'-(dihydrogen phosphate)?

CAS 146-17-8; molecular formula C17H21N4O9P; molecular weight — g/mol.

What other names is Riboflavin 5'-(dihydrogen phosphate) known by?

flavin mononucleotide, 146-17-8, Vitamin B2 phosphate, Riboflavin 5'-phosphate, Riboflavin 5'-monophosphate, Riboflavin 5'-(dihydrogen phosphate).

What is the regulatory status of Riboflavin 5'-(dihydrogen phosphate)?

Documented regulatory listings: FDA Substance added to food: NUTRIENT SUPPLEMENT.

What are the key physical properties of Riboflavin 5'-(dihydrogen phosphate)?

Melting Point: 290 °C; Solubility: 92 mg/mL; Collision Cross Section: 200.2 Ų [M+H]+; Collision Cross Section: 209.3 Ų [M+Na]+.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.