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利血平

CAS 50-55-5C33H40N2O9MW 608.7

利血平(CAS 50-55-5):分子式 C33H40N2O9、分子量 608.7。

产品概览

CAS号50-55-5
分子式C33H40N2O9
分子量608.7
熔点264.5
LogP3.2
应用领域Uses: Antihypertensive、central depressant、and sedative drug for both humans and animals.、Therap cat: Antihypertensive、Therap cat (Vet): Hypotensive、tranquilizer. Has been used to prevent aortic rupture in turkeys.、Foe the treatment of hypertension、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Isolation from roots of Rauwolfia serpentina L Benth、Apocynaceae: Dorfman et al、Helv Chim Acta 37、59 (1954)、Schwyzer、Mueller、US patent 2、833、771 (1958 to Ciba). Structure: Dorfman et al、Loc cit、Neuss et al、J Am Chem Soc 76、2463 (1954). ... synthesis: Woodward et al、J Am Chem Soc 78、2023 (1956).、Impurities: Powdered Rauwolfia serpentia contains several alkaloids. Lactose、starch、or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids、calculated as reserpine.、Formulations、Preparations: Reserpine (Sandril、Serpasil、others) is available in tablets that contain 0.1、0.25 or 1.0 mg or in capsules that contain 0.5 mg、Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg、4 ml、Injection: 5 mg、2 ml、and 25 mg、10 ml、Tablets、0.1、0.25、0.5、and 1 mg、Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil、Apresoline、Hydrochloride #1 (with tartrazine) (Ciba)、0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay)、HHR (Geneva Generics、Schein、Towne)、Hydroserpine Plus (Zenith)、Rezide (Edward)、Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba)、Serathide (Interstate)、Serpazide (Major)、Tri-Hydroserpine (Rugby)、Unipres (Reid-Rowell).、Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil、Esidrix (with tartazine) (Ciba)、0.1 mg with hydrochlorothiazide 50 mg: Serpasil、Esidrix #2 (with tartazine) (Ciba)、0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace)、0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow)、0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals)、Metatensin #4 (Merrell Dow)、Naquival (with tatazine) (Schering)、Trichlormethanizide with resperpine tablets (Bolar、Moore)、Trichlortensin (Rugby)、0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics)、Chloroserpine-250 (Rugby、Schein)、Diupres 250.、For more Formulations、Preparations (Complete) data for RESERPINE (10 total)、please visit the HSDB record page.、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1970) 9.99X10+3 GRAMS、(1983) 4.68X10+4 g、(1984) 103 lb、U.S. Exports: (1972) NEGLIGIBLE、General Manufacturing Information: Yohimban-16-carboxylic acid、11、17-dimethoxy-18-[(3、4、5-trimethoxybenzoyl)oxy]-、methyl ester、(3.beta.、16.beta.、17.alpha.、18.beta.、20.alpha.)-: ACTIVE、SRP: Reserpine、is synthesizable、but not commercially economically feasible. Therefore、companies extract it from the natural product.、A parenteral dosage form of、reserpine、is no longer commerically available in the USA.、It is a crystalline alkaloid derived from Rauwolfia serpentina.

应用领域

登记用途:Uses: Antihypertensive、central depressant、and sedative drug for both humans and animals.、Therap cat: Antihypertensive、Therap cat (Vet): Hypotensive、tranquilizer. Has been used to prevent aortic rupture in turkeys.、Foe the treatment of hypertension、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Isolation from roots of Rauwolfia serpentina L Benth、Apocynaceae: Dorfman et al、Helv Chim Acta 37、59 (1954)、Schwyzer、Mueller、US patent 2、833、771 (1958 to Ciba). Structure: Dorfman et al、Loc cit、Neuss et al、J Am Chem Soc 76、2463 (1954). ... synthesis: Woodward et al、J Am Chem Soc 78、2023 (1956).、Impurities: Powdered Rauwolfia serpentia contains several alkaloids. Lactose、starch、or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids、calculated as reserpine.、Formulations、Preparations: Reserpine (Sandril、Serpasil、others) is available in tablets that contain 0.1、0.25 or 1.0 mg or in capsules that contain 0.5 mg、Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg、4 ml、Injection: 5 mg、2 ml、and 25 mg、10 ml、Tablets、0.1、0.25、0.5、and 1 mg、Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil、Apresoline、Hydrochloride #1 (with tartrazine) (Ciba)、0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay)、HHR (Geneva Generics、Schein、Towne)、Hydroserpine Plus (Zenith)、Rezide (Edward)、Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba)、Serathide (Interstate)、Serpazide (Major)、Tri-Hydroserpine (Rugby)、Unipres (Reid-Rowell).、Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil、Esidrix (with tartazine) (Ciba)、0.1 mg with hydrochlorothiazide 50 mg: Serpasil、Esidrix #2 (with tartazine) (Ciba)、0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace)、0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow)、0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals)、Metatensin #4 (Merrell Dow)、Naquival (with tatazine) (Schering)、Trichlormethanizide with resperpine tablets (Bolar、Moore)、Trichlortensin (Rugby)、0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics)、Chloroserpine-250 (Rugby、Schein)、Diupres 250.、For more Formulations、Preparations (Complete) data for RESERPINE (10 total)、please visit the HSDB record page.、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1970) 9.99X10+3 GRAMS、(1983) 4.68X10+4 g、(1984) 103 lb、U.S. Exports: (1972) NEGLIGIBLE、General Manufacturing Information: Yohimban-16-carboxylic acid、11、17-dimethoxy-18-[(3、4、5-trimethoxybenzoyl)oxy]-、methyl ester、(3.beta.、16.beta.、17.alpha.、18.beta.、20.alpha.)-: ACTIVE、SRP: Reserpine、is synthesizable、but not commercially economically feasible. Therefore、companies extract it from the natural product.、A parenteral dosage form of、reserpine、is no longer commerically available in the USA.、It is a crystalline alkaloid derived from Rauwolfia serpentina.。

技术档案

这个产品是什么

利血平 是一种化工化合物,登记 CAS 号为 50-55-5,分子式 C33H40N2O9(分子量 608.7)。

识别信息

登记 CAS 号:50-55-5

其分子式 C33H40N2O9 由 33 个碳、40 个氢、2 个氮、9 个氧 组成。

别名/同义词:利血平 · Reserpine

常见问题

利血平 的 CAS 号是多少?

利血平 的 CAS 登记号为 50-55-5。

利血平 的分子式与分子量是多少?

分子式 C33H40N2O9,分子量 608.7。

利血平 还有哪些别名?

别名/同义词:利血平、Reserpine。

利血平 的登记用途是什么?

登记用途:Uses: Antihypertensive、central depressant、and sedative drug for both humans and animals.、Therap cat: Antihypertensive、Therap cat (Vet): Hypotensive、tranquilizer. Has been used to prevent aortic rupture in turkeys.、Foe the treatment of hypertension、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Isolation from roots of Rauwolfia serpentina L Benth、Apocynaceae: Dorfman et al、Helv Chim Acta 37、59 (1954)、Schwyzer、Mueller、US patent 2、833、771 (1958 to Ciba). Structure: Dorfman et al、Loc cit、Neuss et al、J Am Chem Soc 76、2463 (1954). ... synthesis: Woodward et al、J Am Chem Soc 78、2023 (1956).、Impurities: Powdered Rauwolfia serpentia contains several alkaloids. Lactose、starch、or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids、calculated as reserpine.、Formulations、Preparations: Reserpine (Sandril、Serpasil、others) is available in tablets that contain 0.1、0.25 or 1.0 mg or in capsules that contain 0.5 mg、Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg、4 ml、Injection: 5 mg、2 ml、and 25 mg、10 ml、Tablets、0.1、0.25、0.5、and 1 mg、Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil、Apresoline、Hydrochloride #1 (with tartrazine) (Ciba)、0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay)、HHR (Geneva Generics、Schein、Towne)、Hydroserpine Plus (Zenith)、Rezide (Edward)、Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba)、Serathide (Interstate)、Serpazide (Major)、Tri-Hydroserpine (Rugby)、Unipres (Reid-Rowell).、Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil、Esidrix (with tartazine) (Ciba)、0.1 mg with hydrochlorothiazide 50 mg: Serpasil、Esidrix #2 (with tartazine) (Ciba)、0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace)、0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow)、0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals)、Metatensin #4 (Merrell Dow)、Naquival (with tatazine) (Schering)、Trichlormethanizide with resperpine tablets (Bolar、Moore)、Trichlortensin (Rugby)、0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics)、Chloroserpine-250 (Rugby、Schein)、Diupres 250.、For more Formulations、Preparations (Complete) data for RESERPINE (10 total)、please visit the HSDB record page.、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1970) 9.99X10+3 GRAMS、(1983) 4.68X10+4 g、(1984) 103 lb、U.S. Exports: (1972) NEGLIGIBLE、General Manufacturing Information: Yohimban-16-carboxylic acid、11、17-dimethoxy-18-[(3、4、5-trimethoxybenzoyl)oxy]-、methyl ester、(3.beta.、16.beta.、17.alpha.、18.beta.、20.alpha.)-: ACTIVE、SRP: Reserpine、is synthesizable、but not commercially economically feasible. Therefore、companies extract it from the natural product.、A parenteral dosage form of、reserpine、is no longer commerically available in the USA.、It is a crystalline alkaloid derived from Rauwolfia serpentina.。

PubChem 公开数据

利血平(CAS 50-55-5)的独立参考数据,整理自公开化学数据库。

各数据库的登记标识

CAS Registry Number50-55-5
PubChem CID5770
Molecular formulaC33H40N2O9
IUPAC namemethyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
UNII (FDA)8B1QWR724A

计算分子描述符

Molecular Weight608.7
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Exact Mass608.27338086
Monoisotopic Mass608.27338086
Topological Polar Surface Area118
Heavy Atom Count44

在册的理化数值

Melting Point264.5
Melting Point264.5 °C
Solubility73
SolubilityIn water, 73 mg/l @ 30 °C
Solubility1.13e-02 g/L
LogP3.2
Ionization Efficiency4.66
Ionization Efficiency2.7
Ionization EfficiencyMeCN (80%)
Ionization EfficiencyDOI:10.1002/rcm.8545

在册的记载用途

    Antihypertensive, central depressant, and sedative drug for both humans and animals.Therap cat (Vet): Hypotensive, tranquilizer. Has been used to prevent aortic rupture in turkeys.

    同义词与商品名

    reserpine; 50-55-5; Serpalan; Serpasil; Apoplon; Sandril; Serpivite; Alserin; Rau-Sed; (-)-Reserpine; Deserpine; Elserpine; Eskaserp; Hiserpia; Raunervil; Raupasil

    GHS 危害分类

    Reported hazard statementsH302 (100%)

    H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

    P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

    公开数据库对它的描述

    Reserpine · CAS 50-55-5 · C33H40N2O9. UNII 8B1QWR724A. Melting Point: 264.5; Melting Point: 264.5 °C; Solubility: 73.

    物理形态与操作说明

    数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。

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