利血平(CAS 50-55-5):分子式 C33H40N2O9、分子量 608.7。
| CAS号 | 50-55-5 |
|---|---|
| 分子式 | C33H40N2O9 |
| 分子量 | 608.7 |
| 熔点 | 264.5 |
| LogP | 3.2 |
| 应用领域 | Uses: Antihypertensive、central depressant、and sedative drug for both humans and animals.、Therap cat: Antihypertensive、Therap cat (Vet): Hypotensive、tranquilizer. Has been used to prevent aortic rupture in turkeys.、Foe the treatment of hypertension、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Isolation from roots of Rauwolfia serpentina L Benth、Apocynaceae: Dorfman et al、Helv Chim Acta 37、59 (1954)、Schwyzer、Mueller、US patent 2、833、771 (1958 to Ciba). Structure: Dorfman et al、Loc cit、Neuss et al、J Am Chem Soc 76、2463 (1954). ... synthesis: Woodward et al、J Am Chem Soc 78、2023 (1956).、Impurities: Powdered Rauwolfia serpentia contains several alkaloids. Lactose、starch、or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids、calculated as reserpine.、Formulations、Preparations: Reserpine (Sandril、Serpasil、others) is available in tablets that contain 0.1、0.25 or 1.0 mg or in capsules that contain 0.5 mg、Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg、4 ml、Injection: 5 mg、2 ml、and 25 mg、10 ml、Tablets、0.1、0.25、0.5、and 1 mg、Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil、Apresoline、Hydrochloride #1 (with tartrazine) (Ciba)、0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay)、HHR (Geneva Generics、Schein、Towne)、Hydroserpine Plus (Zenith)、Rezide (Edward)、Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba)、Serathide (Interstate)、Serpazide (Major)、Tri-Hydroserpine (Rugby)、Unipres (Reid-Rowell).、Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil、Esidrix (with tartazine) (Ciba)、0.1 mg with hydrochlorothiazide 50 mg: Serpasil、Esidrix #2 (with tartazine) (Ciba)、0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace)、0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow)、0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals)、Metatensin #4 (Merrell Dow)、Naquival (with tatazine) (Schering)、Trichlormethanizide with resperpine tablets (Bolar、Moore)、Trichlortensin (Rugby)、0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics)、Chloroserpine-250 (Rugby、Schein)、Diupres 250.、For more Formulations、Preparations (Complete) data for RESERPINE (10 total)、please visit the HSDB record page.、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1970) 9.99X10+3 GRAMS、(1983) 4.68X10+4 g、(1984) 103 lb、U.S. Exports: (1972) NEGLIGIBLE、General Manufacturing Information: Yohimban-16-carboxylic acid、11、17-dimethoxy-18-[(3、4、5-trimethoxybenzoyl)oxy]-、methyl ester、(3.beta.、16.beta.、17.alpha.、18.beta.、20.alpha.)-: ACTIVE、SRP: Reserpine、is synthesizable、but not commercially economically feasible. Therefore、companies extract it from the natural product.、A parenteral dosage form of、reserpine、is no longer commerically available in the USA.、It is a crystalline alkaloid derived from Rauwolfia serpentina. |
登记用途:Uses: Antihypertensive、central depressant、and sedative drug for both humans and animals.、Therap cat: Antihypertensive、Therap cat (Vet): Hypotensive、tranquilizer. Has been used to prevent aortic rupture in turkeys.、Foe the treatment of hypertension、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Isolation from roots of Rauwolfia serpentina L Benth、Apocynaceae: Dorfman et al、Helv Chim Acta 37、59 (1954)、Schwyzer、Mueller、US patent 2、833、771 (1958 to Ciba). Structure: Dorfman et al、Loc cit、Neuss et al、J Am Chem Soc 76、2463 (1954). ... synthesis: Woodward et al、J Am Chem Soc 78、2023 (1956).、Impurities: Powdered Rauwolfia serpentia contains several alkaloids. Lactose、starch、or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids、calculated as reserpine.、Formulations、Preparations: Reserpine (Sandril、Serpasil、others) is available in tablets that contain 0.1、0.25 or 1.0 mg or in capsules that contain 0.5 mg、Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg、4 ml、Injection: 5 mg、2 ml、and 25 mg、10 ml、Tablets、0.1、0.25、0.5、and 1 mg、Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil、Apresoline、Hydrochloride #1 (with tartrazine) (Ciba)、0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay)、HHR (Geneva Generics、Schein、Towne)、Hydroserpine Plus (Zenith)、Rezide (Edward)、Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba)、Serathide (Interstate)、Serpazide (Major)、Tri-Hydroserpine (Rugby)、Unipres (Reid-Rowell).、Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil、Esidrix (with tartazine) (Ciba)、0.1 mg with hydrochlorothiazide 50 mg: Serpasil、Esidrix #2 (with tartazine) (Ciba)、0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace)、0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow)、0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals)、Metatensin #4 (Merrell Dow)、Naquival (with tatazine) (Schering)、Trichlormethanizide with resperpine tablets (Bolar、Moore)、Trichlortensin (Rugby)、0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics)、Chloroserpine-250 (Rugby、Schein)、Diupres 250.、For more Formulations、Preparations (Complete) data for RESERPINE (10 total)、please visit the HSDB record page.、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1970) 9.99X10+3 GRAMS、(1983) 4.68X10+4 g、(1984) 103 lb、U.S. Exports: (1972) NEGLIGIBLE、General Manufacturing Information: Yohimban-16-carboxylic acid、11、17-dimethoxy-18-[(3、4、5-trimethoxybenzoyl)oxy]-、methyl ester、(3.beta.、16.beta.、17.alpha.、18.beta.、20.alpha.)-: ACTIVE、SRP: Reserpine、is synthesizable、but not commercially economically feasible. Therefore、companies extract it from the natural product.、A parenteral dosage form of、reserpine、is no longer commerically available in the USA.、It is a crystalline alkaloid derived from Rauwolfia serpentina.。
利血平 是一种化工化合物,登记 CAS 号为 50-55-5,分子式 C33H40N2O9(分子量 608.7)。
登记 CAS 号:50-55-5
其分子式 C33H40N2O9 由 33 个碳、40 个氢、2 个氮、9 个氧 组成。
别名/同义词:利血平 · Reserpine
利血平 的 CAS 登记号为 50-55-5。
分子式 C33H40N2O9,分子量 608.7。
别名/同义词:利血平、Reserpine。
登记用途:Uses: Antihypertensive、central depressant、and sedative drug for both humans and animals.、Therap cat: Antihypertensive、Therap cat (Vet): Hypotensive、tranquilizer. Has been used to prevent aortic rupture in turkeys.、Foe the treatment of hypertension、Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Isolation from roots of Rauwolfia serpentina L Benth、Apocynaceae: Dorfman et al、Helv Chim Acta 37、59 (1954)、Schwyzer、Mueller、US patent 2、833、771 (1958 to Ciba). Structure: Dorfman et al、Loc cit、Neuss et al、J Am Chem Soc 76、2463 (1954). ... synthesis: Woodward et al、J Am Chem Soc 78、2023 (1956).、Impurities: Powdered Rauwolfia serpentia contains several alkaloids. Lactose、starch、or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids、calculated as reserpine.、Formulations、Preparations: Reserpine (Sandril、Serpasil、others) is available in tablets that contain 0.1、0.25 or 1.0 mg or in capsules that contain 0.5 mg、Dosage Forms- Extended-Release Capsules: 0.5 mg. Elixir: 0.2 mg、4 ml、Injection: 5 mg、2 ml、and 25 mg、10 ml、Tablets、0.1、0.25、0.5、and 1 mg、Reserpine combinations: Oral tablets: 0.1 mg with hydralazine hydrochloride 25 mg: Serpasil、Apresoline、Hydrochloride #1 (with tartrazine) (Ciba)、0.1 mg with hydralazine hydrochloride 25 mg and hydrochlorothiazide 15 mg: Cherpas (Kay)、HHR (Geneva Generics、Schein、Towne)、Hydroserpine Plus (Zenith)、Rezide (Edward)、Ser-A-Gen (Goldline) Ser-Ap-Es (Ciba)、Serathide (Interstate)、Serpazide (Major)、Tri-Hydroserpine (Rugby)、Unipres (Reid-Rowell).、Reserpine combinations: Oral tablets: 0.1 mg with hydrochlorothiazide 25 mg: Serpasil、Esidrix (with tartazine) (Ciba)、0.1 mg with hydrochlorothiazide 50 mg: Serpasil、Esidrix #2 (with tartazine) (Ciba)、0.1 mg with methyclothiazide 2.5 mg: Diutensen-R (Wallace)、0.1 mg with trichloromethiazide: 2 mg: Metatensin #2 (with tartrazine) (Merrell Dow)、0.1 mg with trichlormethiazide 4 mg: Diurese-R (American Urologicals)、Metatensin #4 (Merrell Dow)、Naquival (with tatazine) (Schering)、Trichlormethanizide with resperpine tablets (Bolar、Moore)、Trichlortensin (Rugby)、0.125 mg with chlorothiazide 250 mg: Chloroserp-250 (Quality Generics)、Chloroserpine-250 (Rugby、Schein)、Diupres 250.、For more Formulations、Preparations (Complete) data for RESERPINE (10 total)、please visit the HSDB record page.、U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1970) 9.99X10+3 GRAMS、(1983) 4.68X10+4 g、(1984) 103 lb、U.S. Exports: (1972) NEGLIGIBLE、General Manufacturing Information: Yohimban-16-carboxylic acid、11、17-dimethoxy-18-[(3、4、5-trimethoxybenzoyl)oxy]-、methyl ester、(3.beta.、16.beta.、17.alpha.、18.beta.、20.alpha.)-: ACTIVE、SRP: Reserpine、is synthesizable、but not commercially economically feasible. Therefore、companies extract it from the natural product.、A parenteral dosage form of、reserpine、is no longer commerically available in the USA.、It is a crystalline alkaloid derived from Rauwolfia serpentina.。
利血平(CAS 50-55-5)的独立参考数据,整理自公开化学数据库。
| CAS Registry Number | 50-55-5 |
|---|---|
| PubChem CID | 5770 |
| Molecular formula | C33H40N2O9 |
| IUPAC name | methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate |
| UNII (FDA) | 8B1QWR724A |
| Molecular Weight | 608.7 |
|---|---|
| XLogP3 | 4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 10 |
| Exact Mass | 608.27338086 |
| Monoisotopic Mass | 608.27338086 |
| Topological Polar Surface Area | 118 |
| Heavy Atom Count | 44 |
| Melting Point | 264.5 |
|---|---|
| Melting Point | 264.5 °C |
| Solubility | 73 |
| Solubility | In water, 73 mg/l @ 30 °C |
| Solubility | 1.13e-02 g/L |
| LogP | 3.2 |
| Ionization Efficiency | 4.66 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Ionization Efficiency | DOI:10.1002/rcm.8545 |
reserpine; 50-55-5; Serpalan; Serpasil; Apoplon; Sandril; Serpivite; Alserin; Rau-Sed; (-)-Reserpine; Deserpine; Elserpine; Eskaserp; Hiserpia; Raunervil; Raupasil
| Reported hazard statements | H302 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Reserpine · CAS 50-55-5 · C33H40N2O9. UNII 8B1QWR724A. Melting Point: 264.5; Melting Point: 264.5 °C; Solubility: 73.
数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。
English page: Reserpine