R-(-)-3-奎宁环基苯甲酸酯（CAS 6581-06-2）：分子式 C21H23NO3、分子量 337.4。
| CAS号 | 6581-06-2 |
|---|---|
| 分子式 | C21H23NO3 |
| 分子量 | 337.4 |
| 熔点 | 164 °C |
| LogP | 3.3 |
| 应用领域 | Uses: A High-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies. [ChemIDplus]、Hallucinogenic chemical warfare agent、A high-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies.、BZ itself、now called QNB in the scientific community、is widely used in pharmacology as a muscarinic receptor marker、Atropine-like pharmacodynamic agent used to study drug-receptor interactions in intestinal smooth muscle、Incapacitant、QNB is an incapacitating agent and has been considered historically for use as a chemical warfare agent. A very potent drug、QNB causes confusion and hallucinations、it also affects circulation、digestion、salivation、sweating、and vision. Impairments caused by QNB are generally temporary and unlikely to be fatal、however、they can be severe if exposure is large enough.、Methods of Manufacturing: ... benzilate ester of 3-quinuclidnol formed through acetone-ether actions on parent compound、U.S. Production: The chemical BZ、also known as "agent buzz" was produced at Pine Bluff Arsenal between 1962 and 1965. It was dropped from the chemical arsenal because its effects on enemy front-line troops would be varied and unpredictable.、General Manufacturing Information:、The Chemical Weapons Convention (CWC) is an international treaty which bans the development、production、stockpiling、and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors.、The Convention's monitoring and verification measures involve submission of declarations regarding ...、Schedule 1、2、and 3 chemicals、and inspections by the Organization for the Prohibition of Chemical Weapons of the facilities where these chemicals are produced. ... Schedule 2 lists toxic chemicals and precursors deemed to pose a significant risk to the object and purpose of the CWC because of their lethal or incapacitating properties. Precursors may be used in the final stage for formation、or may be important for the production、of any of the chemicals listed in Schedule 1 or toxic chemicals listed in Schedule 2. Schedule 2 chemicals are not produced in large quantities for commercial ... purposes ... but may be used to manufacture such things as insecticides、herbicides、lubricants or pharmaceutical products (2). BZ is listed in the CWC Annex on Chemicals under Schedule 2 (1).、BZ is the North Atlantic Treaty Organization (NATO) code for 3-quinuclidinyl benzilate、a glycolate anticholinergic also known as 3-QNB.、By the mid-1960s、after a decade of tests、the US Army concluded that the long-acting anticholinergic 3-quinuclidinyl benzilate (BZ) was the best candidate for weaponization and deployment. BZ subsequently was stockpiled in American military arsenals from the mid-1960s through the late-1980s. The US military was not alone in its attempt to develop an incapacitating agent in the 20th century. Seven years after the conclusion of the Gulf War、the British Foreign Ministry revealed、in February 1998、the existence of an Iraqi chemical warfare agent believed to be a glycolate anticholinergic、similar、if not identical、to BZ. It was dubbed "Agent 15."、The U.S. weaponized BZ、but demilitarization began in 1988 and is complete. Agent 15 is an alleged Iraqi incapacitating agent that is likely to be chemically either identical to BZ or closely related to it. Agent 15 was reportedly stockpiled in large quantities prior to and during the Gulf War.、Military field agent that has been dropped from the NATO inventory ... This is not to say it is not manufactured elsewhere |
登记用途：Uses: A High-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies. [ChemIDplus]、Hallucinogenic chemical warfare agent、A high-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies.、BZ itself、now called QNB in the scientific community、is widely used in pharmacology as a muscarinic receptor marker、Atropine-like pharmacodynamic agent used to study drug-receptor interactions in intestinal smooth muscle、Incapacitant、QNB is an incapacitating agent and has been considered historically for use as a chemical warfare agent. A very potent drug、QNB causes confusion and hallucinations、it also affects circulation、digestion、salivation、sweating、and vision. Impairments caused by QNB are generally temporary and unlikely to be fatal、however、they can be severe if exposure is large enough.、Methods of Manufacturing: ... benzilate ester of 3-quinuclidnol formed through acetone-ether actions on parent compound、U.S. Production: The chemical BZ、also known as "agent buzz" was produced at Pine Bluff Arsenal between 1962 and 1965. It was dropped from the chemical arsenal because its effects on enemy front-line troops would be varied and unpredictable.、General Manufacturing Information:、The Chemical Weapons Convention (CWC) is an international treaty which bans the development、production、stockpiling、and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors.、The Convention's monitoring and verification measures involve submission of declarations regarding ...、Schedule 1、2、and 3 chemicals、and inspections by the Organization for the Prohibition of Chemical Weapons of the facilities where these chemicals are produced. ... Schedule 2 lists toxic chemicals and precursors deemed to pose a significant risk to the object and purpose of the CWC because of their lethal or incapacitating properties. Precursors may be used in the final stage for formation、or may be important for the production、of any of the chemicals listed in Schedule 1 or toxic chemicals listed in Schedule 2. Schedule 2 chemicals are not produced in large quantities for commercial ... purposes ... but may be used to manufacture such things as insecticides、herbicides、lubricants or pharmaceutical products (2). BZ is listed in the CWC Annex on Chemicals under Schedule 2 (1).、BZ is the North Atlantic Treaty Organization (NATO) code for 3-quinuclidinyl benzilate、a glycolate anticholinergic also known as 3-QNB.、By the mid-1960s、after a decade of tests、the US Army concluded that the long-acting anticholinergic 3-quinuclidinyl benzilate (BZ) was the best candidate for weaponization and deployment. BZ subsequently was stockpiled in American military arsenals from the mid-1960s through the late-1980s. The US military was not alone in its attempt to develop an incapacitating agent in the 20th century. Seven years after the conclusion of the Gulf War、the British Foreign Ministry revealed、in February 1998、the existence of an Iraqi chemical warfare agent believed to be a glycolate anticholinergic、similar、if not identical、to BZ. It was dubbed "Agent 15."、The U.S. weaponized BZ、but demilitarization began in 1988 and is complete. Agent 15 is an alleged Iraqi incapacitating agent that is likely to be chemically either identical to BZ or closely related to it. Agent 15 was reportedly stockpiled in large quantities prior to and during the Gulf War.、Military field agent that has been dropped from the NATO inventory ... This is not to say it is not manufactured elsewhere。
R-(-)-3-奎宁环基苯甲酸酯 是一种化工化合物，登记 CAS 号为 6581-06-2，分子式 C21H23NO3（分子量 337.4）。
登记 CAS 号：6581-06-2
其分子式 C21H23NO3 由 21 个碳、23 个氢、1 个氮、3 个氧 组成。
别名/同义词：R-(-)-3-奎宁环基苯甲酸酯 · R-(-)-3-quinuclidinyl benzilate
R-(-)-3-奎宁环基苯甲酸酯 的 CAS 登记号为 6581-06-2。
分子式 C21H23NO3，分子量 337.4。
别名/同义词：R-(-)-3-奎宁环基苯甲酸酯、R-(-)-3-quinuclidinyl benzilate。
登记用途：Uses: A High-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies. [ChemIDplus]、Hallucinogenic chemical warfare agent、A high-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies.、BZ itself、now called QNB in the scientific community、is widely used in pharmacology as a muscarinic receptor marker、Atropine-like pharmacodynamic agent used to study drug-receptor interactions in intestinal smooth muscle、Incapacitant、QNB is an incapacitating agent and has been considered historically for use as a chemical warfare agent. A very potent drug、QNB causes confusion and hallucinations、it also affects circulation、digestion、salivation、sweating、and vision. Impairments caused by QNB are generally temporary and unlikely to be fatal、however、they can be severe if exposure is large enough.、Methods of Manufacturing: ... benzilate ester of 3-quinuclidnol formed through acetone-ether actions on parent compound、U.S. Production: The chemical BZ、also known as "agent buzz" was produced at Pine Bluff Arsenal between 1962 and 1965. It was dropped from the chemical arsenal because its effects on enemy front-line troops would be varied and unpredictable.、General Manufacturing Information:、The Chemical Weapons Convention (CWC) is an international treaty which bans the development、production、stockpiling、and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors.、The Convention's monitoring and verification measures involve submission of declarations regarding ...、Schedule 1、2、and 3 chemicals、and inspections by the Organization for the Prohibition of Chemical Weapons of the facilities where these chemicals are produced. ... Schedule 2 lists toxic chemicals and precursors deemed to pose a significant risk to the object and purpose of the CWC because of their lethal or incapacitating properties. Precursors may be used in the final stage for formation、or may be important for the production、of any of the chemicals listed in Schedule 1 or toxic chemicals listed in Schedule 2. Schedule 2 chemicals are not produced in large quantities for commercial ... purposes ... but may be used to manufacture such things as insecticides、herbicides、lubricants or pharmaceutical products (2). BZ is listed in the CWC Annex on Chemicals under Schedule 2 (1).、BZ is the North Atlantic Treaty Organization (NATO) code for 3-quinuclidinyl benzilate、a glycolate anticholinergic also known as 3-QNB.、By the mid-1960s、after a decade of tests、the US Army concluded that the long-acting anticholinergic 3-quinuclidinyl benzilate (BZ) was the best candidate for weaponization and deployment. BZ subsequently was stockpiled in American military arsenals from the mid-1960s through the late-1980s. The US military was not alone in its attempt to develop an incapacitating agent in the 20th century. Seven years after the conclusion of the Gulf War、the British Foreign Ministry revealed、in February 1998、the existence of an Iraqi chemical warfare agent believed to be a glycolate anticholinergic、similar、if not identical、to BZ. It was dubbed "Agent 15."、The U.S. weaponized BZ、but demilitarization began in 1988 and is complete. Agent 15 is an alleged Iraqi incapacitating agent that is likely to be chemically either identical to BZ or closely related to it. Agent 15 was reportedly stockpiled in large quantities prior to and during the Gulf War.、Military field agent that has been dropped from the NATO inventory ... This is not to say it is not manufactured elsewhere。
R-(-)-3-奎宁环基苯甲酸酯（CAS 6581-06-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 6581-06-2 |
|---|---|
| PubChem CID | 23056 |
| Molecular formula | C21H23NO3 |
| IUPAC name | 1-azabicyclo[2.2.2]octan-3-yl 2-hydroxy-2,2-diphenylacetate |
| UNII (FDA) | E69DLR7470 |
| Molecular Weight | 337.4 |
|---|---|
| XLogP3 | 3.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 337.16779360 |
| Monoisotopic Mass | 337.16779360 |
| Topological Polar Surface Area | 49.8 |
| Heavy Atom Count | 25 |
| Melting Point | 164 °C |
|---|---|
| Vapor Density | 11.6 (Air = 1) |
| Vapor Pressure | 0.0000000002 [mm Hg] @25 °C |
3-Quinuclidinyl benzilate; 6581-06-2; DTXSID00894168; NSC-173698; Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 1-azabicyclo(2.2.2)oct-3-yl ester; Benzilate, Quinuclidinyl; Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 1-azabicyclo[2.2.2]oct-3-yl ester; RO-2-3308; RefChem:872080; DTXCID701526727; E69DLR7470; Quinuclidinyl Benzilate; 3-Quinuclidyl benzilate; 3-quinuclidinyl-benzilate; [3H]QNB; 1-azabicyclo[2.2.2]octan-3-yl 2-hydroxy-2,2-diphenylacetate
| Reported hazard statements | H300 (100%) |
|---|
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
R-(-)-3-quinuclidinyl benzilate · CAS 6581-06-2 · C21H23NO3. UNII E69DLR7470. Melting Point: 164 °C; Vapor Density: 11.6 (Air = 1); Vapor Pressure: 0.0000000002 [mm Hg] @25 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: R-(-)-3-quinuclidinyl benzilate