puromycin

Description

puromycin · CAS 53-79-2 · C22H29N7O5. UNII 4A6ZS6Q2CL. Melting Point: 168°C-182°C; Solubility: 50mg/ml; LogP: 0.85.

Identification

CAS Registry Number	53-79-2
PubChem CID	439530
Molecular formula	C22H29N7O5
IUPAC name	(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
UNII (FDA)	4A6ZS6Q2CL

Computed Descriptors

Molecular Weight	471.5
XLogP3	0
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	8
Exact Mass	471.22301705
Monoisotopic Mass	471.22301705
Topological Polar Surface Area	161
Heavy Atom Count	34
Formal Charge	0

Physical & Chemical Properties

Melting Point	168°C-182°C
Solubility	50mg/ml
LogP	0.85

Physical description & handling notes

• 197.6 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 203.92 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 212.55 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 210.53 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Documented Uses

• Antimetabolites that are useful in cancer chemotherapy.
• Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
• Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

Synonyms

puromycin; 53-79-2; Stylomycin; Puromicina; Puromycine; Puromycinum; Stillomycin; P-638; 3123L; GNF-PF-2016; CL 13,900; CHEBI:17939; CL-13900; 4A6ZS6Q2CL; 3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine; CL 13900

Frequently Asked Questions

What are the CAS number and molecular formula of puromycin?

CAS 53-79-2; molecular formula C22H29N7O5; molecular weight — g/mol.

What other names is puromycin known by?

puromycin, 53-79-2, Stylomycin, Puromicina, Puromycine, Puromycinum.

What are the key physical properties of puromycin?

Melting Point: 168°C-182°C; Solubility: 50mg/ml; LogP: 0.85.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.