Proteins, thaumatins

Description

Thaumatin · CAS 428847-42-1 · C19H29N3O3S. UNII KNC9Q0EE6G.

Identification

CAS Registry Number	428847-42-1
PubChem CID	1151816
Molecular formula	C19H29N3O3S
IUPAC name	N-[4-(4-cycloheptylpiperazin-1-yl)sulfonylphenyl]acetamide
UNII (FDA)	KNC9Q0EE6G
FEMA number	3732

Computed Descriptors

Molecular Weight	379.5
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	379.19296297
Monoisotopic Mass	379.19296297
Topological Polar Surface Area	78.1
Heavy Atom Count	26
Formal Charge	0

Physical description & handling notes

• INTENSELY SWEET, LICORICE AFTERTASTE
• STRONGLY CATIONIC; ISOELECTRIC POINT APPROX 11.7; ABOUT 750-1600 TIMES SWEETER THAN SUCROSE ON A WT BASIS, 30,000-100,000 TIMES ON A MOLAR BASIS; THE PROTEIN LOSES SWEETNESS ON HEATING, ON SPLITTING OF DISULFIDE BRIDGES & ALSO AT PH LESS THAN 2.5; MOL WT OF EACH POLYPEPTIDE IS ABOUT 21,000 (DETERMINED FROM ULTRACENTRIFUGAL DATA); TASTE THRESHOLD: NEAR 1x10-4%

Regulatory Status

Regulatory & Food Contact	FDA Substance added to food: FLAVORING AGENT OR ADJUVANT FLAVOUR_ENHANCER; SWEETENER: Food Additives At low levels can alter the perception of sweetness and alter the perception of various flavor characteristics Scientific procedures FDA has no questions (in PDF) Nomad Bioscience GmbH
GHS notification summary	51.3% (77 / 150)

GHS Hazard Classification

GHS notification summary	51.3% (77 / 150)
Reported hazard statements	H334 (46.7%), H335 (12%)

Documented Uses

• POTENTIAL LOW-CALORIE SWEETENER
• Food Additives -> FLAVOUR_ENHANCER; SWEETENER -> JECFA Functional Classes
• EXTRACTION OF THAUMATIN FROM THAUMATOCOCCUS DANIELLI: J HIGGINBOTHAM; US PATENT NUMBER 4,011,206 (1976 TO TATE AND LYLE, LTD). CT VERRIPS, EUROPEAN PATENT APPL 54,330 AND 54,331 (BOTH 1982 TO UNILEVER).
• COMPRISED OF TWO ELECTROPHORETIC SPECIES, THAUMATINS I AND II, ONE OF WHICH APPEARS TO BE A PARTIALLY DEAMINATED FORM OF THE OTHER. ... THE PROTEIN CONSISTS OF A SINGLE POLYPEPTIDE CHAIN OF 207 RESIDUES; FIVE SETS OF TRIPEPTIDES ARE IDENTICAL WITH TRIPEPTIDES IN MONELLIN.
• Thaumatin was one of the sweetening agents studied & found to be low in cariogenic action. No deleterious effect of its use has been found.
• Various maturation forms of the plant protein thaumatin were expressed in yeast, using a promoter fragment of the glyceraldehyde-3P-dehydrogenase (GAPDH) gene. Nucleotide sequence analysis of 843 nucleotide GAPDH promoter fragment revealed a characteristic structure with 2 regions of dyad symmetry containing translational starts of GAPDH and a putative 38 amino acid peptide.

Synonyms

N-[4-(4-cycloheptylpiperazine-1-sulfonyl)phenyl]acetamide; Proteins, thaumatins; N-(4-(4-cycloheptylpiperazine-1-sulfonyl)phenyl)acetamide; Neo san maruku ag; Neo san maruku dc; Thaumatin [BAN]; Sansweet t 147; RefChem:897602; KNC9Q0EE6G; FEMA No. 3732; INS NO.957; HSDB 3927; INS-957; DTXSID101018112; EINECS 258-822-2; E-957

Frequently Asked Questions

What are the CAS number and molecular formula of Thaumatin?

CAS 428847-42-1; molecular formula C19H29N3O3S; molecular weight — g/mol.

What other names is Thaumatin known by?

N-[4-(4-cycloheptylpiperazine-1-sulfonyl)phenyl]acetamide, Proteins, thaumatins, N-(4-(4-cycloheptylpiperazine-1-sulfonyl)phenyl)acetamide, Neo san maruku ag, Neo san maruku dc, Thaumatin [BAN].

What is the regulatory status of Thaumatin?

Documented regulatory listings: FDA Substance added to food: FLAVORING AGENT OR ADJUVANT; FLAVOUR_ENHANCER; SWEETENER: Food Additives; At low levels can alter the perception of sweetness and alter the perception of various flavor characteristics.

Is Thaumatin classified as hazardous?

51.3% of GHS notifications report no hazard classification (77 of 150).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.