盐酸普拉莫辛

Description

Pramoxine Hydrochloride · CAS 637-58-1 · C17H28ClNO3. UNII 88AYB867L5. Melting Point: 181-183 °C.

Identification

CAS Registry Number	637-58-1
PubChem CID	73957
Molecular formula	C17H28ClNO3
IUPAC name	4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride
UNII (FDA)	88AYB867L5

Computed Descriptors

Molecular Weight	329.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	329.1757714
Monoisotopic Mass	329.1757714
Topological Polar Surface Area	30.9
Heavy Atom Count	22
Formal Charge	0
Complexity	248

Physical & Chemical Properties

Melting Point	181-183 °C

Physical description & handling notes

• Crystals
• Freely soluble in water
• >49.5 [ug/mL] (The mean of the results at pH 7.4)
• 178.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (99.3%), H319 (99.3%), H335 (98.5%)

Documented Uses

• Information on 1 consumer products that contain Pramoxine hydrochloride in the following categories is provided:
• Indicated for the symptomatic relief of: hemorrhoids, anorectal inflammation and anorectal pain. (these medications /including pramoxine/ are effective when applied to the anal, periana, or anorectal areas. However, they are not likely to relieve symptoms associated with conditions confined to the rectum, which lacks sensory nerve fibers.) /Included in US product labeling/
• Pramoxine preparations are used topically for the temporary relief of pain and itching associated with dermatoses; rashes due to poison ivy, poison oak, poison sumac, insect bites; minor burns; anogenital pruritus or irritation; and fissures; or hemorrhoids. The drug should not be used for bronchoscopy or gastroscopy since it is not sufficiently potent to abolish the gag reflex.
• Local effects, such as burning or stinging, may occur following topical application of pramoxine. The drug has a low index of sensitization, and cross-sensitization with other local anesthetics is unlikely.
• Topical pramoxine preparations should not be used in or near the eyes or nose.
• The preparations should not be applied to extensive areas of skin and are not for prolonged use. The aerosol foam for rectal administration should not be used longer than 4 consecutive weeks.

Synonyms

Pramoxine hydrochloride; 637-58-1; Pramoxine HCl; Pramocaine hydrochloride; Tronothane; DTXSID2047777; NSC-25573; Walgreen Anti-Itch; Pramoxine hydrochloride [USP]; 88AYB867L5; 4-(3-(p-Butoxyphenoxy)propyl)morpholine hydrochloride; 4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride; Pramoxine hydrochloride (USP); DTXCID2027757; NSC25573; CVS Health Maximum Strength Feminine

Frequently Asked Questions

What are the CAS number and molecular formula of Pramoxine Hydrochloride?

CAS 637-58-1; molecular formula C17H28ClNO3; molecular weight — g/mol.

What other names is Pramoxine Hydrochloride known by?

Pramoxine hydrochloride, 637-58-1, Pramoxine HCl, Pramocaine hydrochloride, Tronothane, DTXSID2047777.

Is Pramoxine Hydrochloride classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

What are the key physical properties of Pramoxine Hydrochloride?

Melting Point: 181-183 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.