普乐洛尔

Description

practolol · CAS 6673-35-4 · C14H22N2O3. UNII SUG9176GRW. Melting Point: 134-136 °C; Melting Point: 134 - 136 °C; Solubility: 4.90e-01 g/L.

Identification

CAS Registry Number	6673-35-4
PubChem CID	4883
Molecular formula	C14H22N2O3
IUPAC name	N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
UNII (FDA)	SUG9176GRW

Computed Descriptors

Molecular Weight	266.34
XLogP3	0.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	266.16304257
Monoisotopic Mass	266.16304257
Topological Polar Surface Area	70.6
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	134-136 °C
Melting Point	134 - 136 °C
Solubility	4.90e-01 g/L
LogP	0.79
LogP	0.74

Physical description & handling notes

• Solid
• Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias. Beta blockers inhibit normal epinephrine-mediated sympathetic actions, but have minimal effect on resting subjects. That is, they reduce the effect of excitement/physical exertion on heart rate and force of contraction and dilation of blood vessels.

GHS Hazard Classification

Reported hazard statements	H302 (50%), H315 (50%), H361 (100%), H373 (50%)

Documented Uses

• Used in the emergency treatment of cardiac arrhythmias.
• Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
• Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.
• C07AB - Beta blocking agents, selective
• QC07AB - Beta blocking agents, selective
• Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure.

Synonyms

practolol; 6673-35-4; Dalzic; Eraldin; Practololum; ICI 50172; ICI-50172; N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE; DTXSID0021179; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide; (+-)-Practolol; 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide; N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide; AY-21011; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide

Frequently Asked Questions

What are the CAS number and molecular formula of practolol?

CAS 6673-35-4; molecular formula C14H22N2O3; molecular weight — g/mol.

What other names is practolol known by?

practolol, 6673-35-4, Dalzic, Eraldin, Practololum, ICI 50172.

Is practolol classified as hazardous?

Hazard statements reported: H302, H315, H361, H373.

What are the key physical properties of practolol?

Melting Point: 134-136 °C; Melting Point: 134 - 136 °C; Solubility: 4.90e-01 g/L; LogP: 0.79.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.