Posaconazole（CAS 171228-49-2）：分子式 C37H42F2N8O4、分子量 700.8；类别 有机化学品。
| CAS号 | 171228-49-2 |
|---|---|
| 分子式 | C37H42F2N8O4 |
| 分子量 | 700.8 |
| LogP | 5.5 |
| 应用领域 | Uses: For prophylaxis of invasive <em>Aspergillus<、em> and <em>Candida<、em> infections in patients、13 years of age and older、who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD)、or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis、including oropharyngeal candidiasis refractory to itraconazole and、or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis、<em>Fusarium<、em> infections、and zygomycosis in patients who are intolerant of、or whose disease is refractory to、other antifungals.、Use Classification: Fungicides |
| 类别 | Organic Chemicals |
登记用途：Uses: For prophylaxis of invasive <em>Aspergillus<、em> and <em>Candida<、em> infections in patients、13 years of age and older、who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD)、or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis、including oropharyngeal candidiasis refractory to itraconazole and、or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis、<em>Fusarium<、em> infections、and zygomycosis in patients who are intolerant of、or whose disease is refractory to、other antifungals.、Use Classification: Fungicides。
Posaconazole 是一种以碳骨架为基础的有机化合物，登记 CAS 号为 171228-49-2，分子式 C37H42F2N8O4（分子量 700.8），归属于有机化学品大类化工原料。
登记 CAS 号：171228-49-2
其分子式 C37H42F2N8O4 由 37 个碳、42 个氢、2 个氟、8 个氮、4 个氧 组成。
别名/同义词：Posaconazole
所属分类：有机化学品
Posaconazole 的 CAS 登记号为 171228-49-2。
分子式 C37H42F2N8O4，分子量 700.8。
别名/同义词：Posaconazole。
登记用途：Uses: For prophylaxis of invasive <em>Aspergillus<、em> and <em>Candida<、em> infections in patients、13 years of age and older、who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD)、or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis、including oropharyngeal candidiasis refractory to itraconazole and、or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis、<em>Fusarium<、em> infections、and zygomycosis in patients who are intolerant of、or whose disease is refractory to、other antifungals.、Use Classification: Fungicides。
所属分类：Organic Chemicals。
Posaconazole（CAS 171228-49-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 171228-49-2 |
|---|---|
| PubChem CID | 147912 |
| Molecular formula | C37H42F2N8O4 |
| IUPAC name | 4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one |
| UNII (FDA) | BDBM213824 |
| Molecular Weight | 700.8 |
|---|---|
| XLogP3 | 4.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 12 |
| Exact Mass | 700.32970817 |
| Monoisotopic Mass | 700.32970817 |
| Topological Polar Surface Area | 112 |
| Heavy Atom Count | 51 |
| Solubility | 1.20e-02 g/L |
|---|---|
| LogP | 5.5 |
SR-01000942256; DSSTox_GSID_49066; NCGC00185736-01; SCHEMBL37449; CHEMBL221872; BDBM213824; AKOS015902506; NCGC00185736-02; SR-01000942256-1; SR-01000942256-2; Q56867649
Posaconazole · CAS 171228-49-2 · C37H42F2N8O4. UNII BDBM213824. Solubility: 1.20e-02 g/L; LogP: 5.5.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Posaconazole