Polyethylene Glycol 400 (CAS 107-21-1) — formula C2H6O2, molecular weight 62.07; category pharmaceutical intermediates and APIs.
| CAS Number | 107-21-1 |
|---|---|
| Molecular Formula | C2H6O2 |
| Molecular Weight | 62.07 |
| Melting Point | 9 °F (NTP, 1992) |
| Boiling Point | 387.7 °F at 760 mmHg (NTP, 1992) |
| LogP | -1.4 |
| Applications | Uses: CIR ingredient: Ethylene Glycol, Ethylene glycol is used as antifreeze in cooling and heating systems, in hydraulic brake fluids, as an industrial humectant, as an ingredient of electrolytic condensers, as a solvent in the paint and plastics industries, in the formulations of printers' inks, stamp pad inks, and inks for ballpoint pens, as a softening agent for cellophane, and in the synthesis of safety explosives, plasticizers, synthetic fibers (Terylene, Dacron), and synthetic waxes., Used in antifreeze and deicing solutions for cars, boats, and aircraft, also used as a solvent for paints, plastics, photographic developing solutions, coolants, hydraulic fluids, and inks, [ATSDR ToxFAQs] Highest risk for exposure in deicing aircraft and runways, [Reference #2] Occupational exposure mainly through skin and eyes, but also inhalation if heated or aerosolized, 50% solution used to de-ice bridges, Has been used in adhesives, polishes, cosmetics, and pharmaceuticals, [ACGIH], Painting (Solvents) [Category: Paint], Working with Glues and Adhesives [Category: Other], Photographic Processing [Category: Other], Both oil base and water base fracturing fluids are being used in the fracturing industry. Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids. The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer., Hydraulic fracturing, Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground. These cracks in the rock then allow oil and natural gas to flow, increasing resource production. ... Chemical Name: Ethylene glycol, Chemical Purpose: Product stabilizer and, or winterizing agent, Product Function: Non-Emulsifier., For ethylene glycol (USEPA, OPP Pesticide Code: 042203) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., The active ingredient is no longer contained in any registered pesticide products ... "cancelled.", For more Uses (Complete) data for ETHYLENE GLYCOL (8 total), please visit the HSDB record page., Ethylene glycol is a useful industrial compound found in many consumer products. Examples include antifreeze, hydraulic brake fluids, some stamp pad inks, ballpoint pens, solvents, paints, films, and cosmetics. It can also be a pharmaceutical vehicle. Ethylene glycol has a sweet taste and is often ingested by accident or on purpose. Ethylene glycol breaks down into toxic compounds in the body. Ethylene glycol and its toxic byproducts first affect the central nervous system (CNS), then the heart, and finally the kidneys. Ingesting enough can cause death. Ethylene glycol is odorless., The major use of ethylene glycol is as a coolant or antifreeze in, for example, automobiles and personal computers. Ethylene glycol has become increasingly important in the plastics industry for the manufacture of polyester fibers and resins, including polyethylene terephthalate, which is used to make plastic bottles for soft drinks. (L1023), Use Classification: Food additives, Food Additives -> ADJUVANT, CARRIER_SOLVENT -> JECFA Functional Classes, Cosmetics -> Humectant, Viscosity controlling, Solvent, SOLVENTS, Industry Uses: Processing aids not otherwise specified, Monomers, Surfactant (surface active agent), Plating agent, Heat transferring agent, Fuel, pH regulating agent, Anti-adhesive, cohesive, Anti-freeze agent, Binder, Other, Freeze-thaw additive, Lubricating agent, Processing aids, specific to petroleum production, Intermediate, Laboratory chemicals, Hydraulic fluids, Plasticizer, Refrigerants, Corrosion inhibitor, Filler, Diluent, Not Known or Reasonably Ascertainable, Catalyst, Emulsifier, Soil amendments (fertilizers), Consumer Uses: Processing aids, Adhesion, cohesion promoter, Coalescing agent, Insulators, Household Products: Cosmetics product ingredient: Ethylene glycol (Glycol), Also known as: 1, 2-ethanediol, glycol, ethylene alcohol, monoethylene glycol, Source: Ethylene glycol is produced synthetically from other chemicals. Various industrial applications use it. Ethylene glycol may be added to cosmetics to dissolve other ingredients or to thin or dilute the cosmetic. It may also be added as a component of fragrance or to keep a product moist., Potential health impacts: People may be exposed to ethylene glycol through ingestion or skin contact or absorption. High doses of ethylene glycol can cause central nervous system depression, gastrointestinal distress, kidney toxicity, and death. Inhaling ethylene glycol can cause irritation to the upper respiratory tract. Skin exposure to ethylene glycol can cause skin irritation. The National Toxicology Program (NTP) has not found sufficient evidence of reproductive or developmental effects., Product count: 56, Information on 908 consumer products that contain Ethylene glycol in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Hobby, Craft, • Home Maintenance, • Inside the Home, • Landscaping, Yard, • Personal Care, • Pesticides, Methods of Manufacturing:, Industrial production, is based on the hydrolysis of ethylene oxide obtained by direct oxidation of ethylene with air or oxygen. The ethylene oxide is therma |
| Category | Pharma Excipients |
Documented applications: Uses: CIR ingredient: Ethylene Glycol, Ethylene glycol is used as antifreeze in cooling and heating systems, in hydraulic brake fluids, as an industrial humectant, as an ingredient of electrolytic condensers, as a solvent in the paint and plastics industries, in the formulations of printers' inks, stamp pad inks, and inks for ballpoint pens, as a softening agent for cellophane, and in the synthesis of safety explosives, plasticizers, synthetic fibers (Terylene, Dacron), and synthetic waxes., Used in antifreeze and deicing solutions for cars, boats, and aircraft, also used as a solvent for paints, plastics, photographic developing solutions, coolants, hydraulic fluids, and inks, [ATSDR ToxFAQs] Highest risk for exposure in deicing aircraft and runways, [Reference #2] Occupational exposure mainly through skin and eyes, but also inhalation if heated or aerosolized, 50% solution used to de-ice bridges, Has been used in adhesives, polishes, cosmetics, and pharmaceuticals, [ACGIH], Painting (Solvents) [Category: Paint], Working with Glues and Adhesives [Category: Other], Photographic Processing [Category: Other], Both oil base and water base fracturing fluids are being used in the fracturing industry. Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids. The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer., Hydraulic fracturing, Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground. These cracks in the rock then allow oil and natural gas to flow, increasing resource production. ... Chemical Name: Ethylene glycol, Chemical Purpose: Product stabilizer and, or winterizing agent, Product Function: Non-Emulsifier., For ethylene glycol (USEPA, OPP Pesticide Code: 042203) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., The active ingredient is no longer contained in any registered pesticide products ... "cancelled.", For more Uses (Complete) data for ETHYLENE GLYCOL (8 total), please visit the HSDB record page., Ethylene glycol is a useful industrial compound found in many consumer products. Examples include antifreeze, hydraulic brake fluids, some stamp pad inks, ballpoint pens, solvents, paints, films, and cosmetics. It can also be a pharmaceutical vehicle. Ethylene glycol has a sweet taste and is often ingested by accident or on purpose. Ethylene glycol breaks down into toxic compounds in the body. Ethylene glycol and its toxic byproducts first affect the central nervous system (CNS), then the heart, and finally the kidneys. Ingesting enough can cause death. Ethylene glycol is odorless., The major use of ethylene glycol is as a coolant or antifreeze in, for example, automobiles and personal computers. Ethylene glycol has become increasingly important in the plastics industry for the manufacture of polyester fibers and resins, including polyethylene terephthalate, which is used to make plastic bottles for soft drinks. (L1023), Use Classification: Food additives, Food Additives -> ADJUVANT, CARRIER_SOLVENT -> JECFA Functional Classes, Cosmetics -> Humectant, Viscosity controlling, Solvent, SOLVENTS, Industry Uses: Processing aids not otherwise specified, Monomers, Surfactant (surface active agent), Plating agent, Heat transferring agent, Fuel, pH regulating agent, Anti-adhesive, cohesive, Anti-freeze agent, Binder, Other, Freeze-thaw additive, Lubricating agent, Processing aids, specific to petroleum production, Intermediate, Laboratory chemicals, Hydraulic fluids, Plasticizer, Refrigerants, Corrosion inhibitor, Filler, Diluent, Not Known or Reasonably Ascertainable, Catalyst, Emulsifier, Soil amendments (fertilizers), Consumer Uses: Processing aids, Adhesion, cohesion promoter, Coalescing agent, Insulators, Household Products: Cosmetics product ingredient: Ethylene glycol (Glycol), Also known as: 1, 2-ethanediol, glycol, ethylene alcohol, monoethylene glycol, Source: Ethylene glycol is produced synthetically from other chemicals. Various industrial applications use it. Ethylene glycol may be added to cosmetics to dissolve other ingredients or to thin or dilute the cosmetic. It may also be added as a component of fragrance or to keep a product moist., Potential health impacts: People may be exposed to ethylene glycol through ingestion or skin contact or absorption. High doses of ethylene glycol can cause central nervous system depression, gastrointestinal distress, kidney toxicity, and death. Inhaling ethylene glycol can cause irritation to the upper respiratory tract. Skin exposure to ethylene glycol can cause skin irritation. The National Toxicology Program (NTP) has not found sufficient evidence of reproductive or developmental effects., Product count: 56, Information on 908 consumer products that contain Ethylene glycol in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Hobby, Craft, • Home Maintenance, • Inside the Home, • Landscaping, Yard, • Personal Care, • Pesticides, Methods of Manufacturing:, Industrial production, is based on the hydrolysis of ethylene oxide obtained by direct oxidation of ethylene with air or oxygen. The ethylene oxide is therma.
Polyethylene Glycol 400 is a pharmaceutical intermediate or API compound with CAS registry number 107-21-1 and molecular formula C2H6O2 (molecular weight 62.07), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 107-21-1
Its molecular formula C2H6O2 comprises 2 C, 6 H, 2 O atoms.
Also known as: Polyethylene Glycol 400 · Ethylene glycol · PEG 1000 · Polyethylene glycol 200
Category: pharmaceutical intermediates and APIs
The CAS registry number of Polyethylene Glycol 400 is 107-21-1.
Molecular formula C2H6O2, molecular weight 62.07.
It is also registered under: Polyethylene Glycol 400, Ethylene glycol, PEG 1000, Polyethylene glycol 200.
Recorded applications: Uses: CIR ingredient: Ethylene Glycol, Ethylene glycol is used as antifreeze in cooling and heating systems, in hydraulic brake fluids, as an industrial humectant, as an ingredient of electrolytic condensers, as a solvent in the paint and plastics industries, in the formulations of printers' inks, stamp pad inks, and inks for ballpoint pens, as a softening agent for cellophane, and in the synthesis of safety explosives, plasticizers, synthetic fibers (Terylene, Dacron), and synthetic waxes., Used in antifreeze and deicing solutions for cars, boats, and aircraft, also used as a solvent for paints, plastics, photographic developing solutions, coolants, hydraulic fluids, and inks, [ATSDR ToxFAQs] Highest risk for exposure in deicing aircraft and runways, [Reference #2] Occupational exposure mainly through skin and eyes, but also inhalation if heated or aerosolized, 50% solution used to de-ice bridges, Has been used in adhesives, polishes, cosmetics, and pharmaceuticals, [ACGIH], Painting (Solvents) [Category: Paint], Working with Glues and Adhesives [Category: Other], Photographic Processing [Category: Other], Both oil base and water base fracturing fluids are being used in the fracturing industry. Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids. The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer., Hydraulic fracturing, Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground. These cracks in the rock then allow oil and natural gas to flow, increasing resource production. ... Chemical Name: Ethylene glycol, Chemical Purpose: Product stabilizer and, or winterizing agent, Product Function: Non-Emulsifier., For ethylene glycol (USEPA, OPP Pesticide Code: 042203) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., The active ingredient is no longer contained in any registered pesticide products ... "cancelled.", For more Uses (Complete) data for ETHYLENE GLYCOL (8 total), please visit the HSDB record page., Ethylene glycol is a useful industrial compound found in many consumer products. Examples include antifreeze, hydraulic brake fluids, some stamp pad inks, ballpoint pens, solvents, paints, films, and cosmetics. It can also be a pharmaceutical vehicle. Ethylene glycol has a sweet taste and is often ingested by accident or on purpose. Ethylene glycol breaks down into toxic compounds in the body. Ethylene glycol and its toxic byproducts first affect the central nervous system (CNS), then the heart, and finally the kidneys. Ingesting enough can cause death. Ethylene glycol is odorless., The major use of ethylene glycol is as a coolant or antifreeze in, for example, automobiles and personal computers. Ethylene glycol has become increasingly important in the plastics industry for the manufacture of polyester fibers and resins, including polyethylene terephthalate, which is used to make plastic bottles for soft drinks. (L1023), Use Classification: Food additives, Food Additives -> ADJUVANT, CARRIER_SOLVENT -> JECFA Functional Classes, Cosmetics -> Humectant, Viscosity controlling, Solvent, SOLVENTS, Industry Uses: Processing aids not otherwise specified, Monomers, Surfactant (surface active agent), Plating agent, Heat transferring agent, Fuel, pH regulating agent, Anti-adhesive, cohesive, Anti-freeze agent, Binder, Other, Freeze-thaw additive, Lubricating agent, Processing aids, specific to petroleum production, Intermediate, Laboratory chemicals, Hydraulic fluids, Plasticizer, Refrigerants, Corrosion inhibitor, Filler, Diluent, Not Known or Reasonably Ascertainable, Catalyst, Emulsifier, Soil amendments (fertilizers), Consumer Uses: Processing aids, Adhesion, cohesion promoter, Coalescing agent, Insulators, Household Products: Cosmetics product ingredient: Ethylene glycol (Glycol), Also known as: 1, 2-ethanediol, glycol, ethylene alcohol, monoethylene glycol, Source: Ethylene glycol is produced synthetically from other chemicals. Various industrial applications use it. Ethylene glycol may be added to cosmetics to dissolve other ingredients or to thin or dilute the cosmetic. It may also be added as a component of fragrance or to keep a product moist., Potential health impacts: People may be exposed to ethylene glycol through ingestion or skin contact or absorption. High doses of ethylene glycol can cause central nervous system depression, gastrointestinal distress, kidney toxicity, and death. Inhaling ethylene glycol can cause irritation to the upper respiratory tract. Skin exposure to ethylene glycol can cause skin irritation. The National Toxicology Program (NTP) has not found sufficient evidence of reproductive or developmental effects., Product count: 56, Information on 908 consumer products that contain Ethylene glycol in the following categories is provided:, • Auto Products, • Commercial, Institutional, • Hobby, Craft, • Home Maintenance, • Inside the Home, • Landscaping, Yard, • Personal Care, • Pesticides, Methods of Manufacturing:, Industrial production, is based on the hydrolysis of ethylene oxide obtained by direct oxidation of ethylene with air or oxygen. The ethylene oxide is therma.
Category: Pharma Excipients.
Independent reference data for Polyethylene Glycol 400 (CAS 107-21-1), compiled from public chemistry databases.
| CAS Registry Number | 107-21-1 |
|---|---|
| PubChem CID | 174 |
| Molecular formula | C2H6O2 |
| IUPAC name | ethane-1,2-diol |
| UNII (FDA) | FC72KVT52F |
| Molecular Weight | 62.07 |
|---|---|
| XLogP3 | -1.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 62.036779430 |
| Monoisotopic Mass | 62.036779430 |
| Topological Polar Surface Area | 40.5 |
| Heavy Atom Count | 4 |
| Boiling Point | 387.7 °F at 760 mmHg (NTP, 1992) |
|---|---|
| Boiling Point | 197.3 °C |
| Boiling Point | 197.00 to 198.00 °C. @ 760.00 mm Hg |
| Boiling Point | 197 °C |
| Boiling Point | 388 °F |
| Boiling Point | 197.3 °C @760 [mm Hg] |
| Melting Point | 9 °F (NTP, 1992) |
| Melting Point | -12.69 °C |
| Melting Point | 4 - 10 °C |
| Melting Point | -13 °C |
ETHYLENE GLYCOL; Ethane-1,2-diol; 107-21-1; 1,2-ethanediol; glycol; monoethylene glycol; 2-hydroxyethanol; 1,2-Dihydroxyethane; Glycol alcohol; Ethylene alcohol; Fridex; Tescol; Norkool; Ethylene dihydrate; Zerex; ethanediol
| Regulatory & Food Contact | FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS ADJUVANT; CARRIER_SOLVENT: Food Additives Addition polymers of ethylene oxide and water usually designated by a number roughly corresponding to the mole MACROGOL JECFA ADI: 0-10 mg/kg bw |
|---|---|
| GHS notification summary | 0.1% (3 / 8196) |
| GHS notification summary | 0.1% (3 / 8196) |
|---|---|
| Reported hazard statements | H302, H373 (24.8%), H315, H320, H332, H335, H336, H370 |
H302: Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Polyethylene glycol 200 · CAS 107-21-1 · C2H6O2. UNII FC72KVT52F. Boiling Point: 387.7 °F at 760 mmHg (NTP, 1992); Boiling Point: 197.3 °C; Boiling Point: 197.00 to 198.00 °C. @ 760.00 mm Hg.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
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