毛果芸香碱（CAS 92-13-7）：分子式 C11H16N2O2、分子量 208.26。
| CAS号 | 92-13-7 |
|---|---|
| 分子式 | C11H16N2O2 |
| 分子量 | 208.26 |
| 熔点 | 195-205 |
| LogP | -3.03 |
| 应用领域 | Uses: MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 75.1、For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjö、grens syndrome.、Methods of Manufacturing: TOTAL ALKALOIDS ARE EXTRACTED FROM...SUITABLE PILOCARPUS SPECIES、WITH ALC CONTAINING SMALL AMT OF HYDROCHLORIC ACID. SOLVENT DISTD OFF...RESINS ARE ALL DEPOSITED. ...FILTERED...EVAPORATED TO SMALL BULK. AMMONIA IS ADDED IN EXCESS & FREE ALKALOIDS EXTRACTED WITH CHLOROFORM.、PREOBRASHENSKI ET AL、BER 66、1187 (1933)、SAMOKH ALOV、MED PROM SSSR 11、NO 2、10 (1957)...、Formulations、Preparations: ADSORBOCARPINE (BURTON、PARSONS)...ALMOCARPINE (AYERST)...ISOPTO CARPINE (ALCON)...MI-PILO (BARNES-HIND)...MISTURA P (LEDERLE)...PILOCAR (SMP)...PILOCEL (SOFTCON PRODUCTS)...PILOMIOTON (SMP)...、HCL、PV CARPINE LIQUIFILM (ALLERGAN)...PILOFRIN LIQUIFILM (ALLERGAN)...、NITRATE、OCUSERT PILO-20、PILO-40、(ALZA)、General Manufacturing Information: 2(3H)-Furanone、3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-、(3S、4R)-: ACTIVE、PILOCARPINE、HAS CIS CONFIGURATION、ISOPILOCARPINE IS TRANS: ZAV'VANOL、DOKLADY ADAD NAUK SSSR 82、257 (1952). ABSOLUTE CONFIGURATION: HILL、BARCZA、TETRAHEDRON 22、2889 (1966).、INCOMPATIBILITIES: SILVER NITRATE、MERCURY BICHLORIDE、IODIDES、GOLD SALTS、TANNIN、CALOMEL、POTASSIUM PERMANGANATE、ALKALIES.、OCUSERT、...IS ELLIPTICALLY SHAPED UNIT...OF PILOCARPINE-CONTAINING RESERVOIR SURROUNDED BY PERMEABLE MEMBRANE. FOLLOWING PLACEMENT BY PT、DIFFERENT FORMS OF UNIT ARE DESIGNED TO RELEASE PILOCARPINE @ RATE OF EITHER 20 OR 40 UG、HR FOR 1 WK. INTRAOCULAR PRESSURE IS REDUCED CONTINUOUSLY...WITH...LESS TOTAL DRUG...、PILOCARPINE HYDROCHLORIDE & PILOCARPINE NITRATE ARE OFFICIAL IN USP BOTH AS SALTS & AS OPHTHALMIC SOLN. AVG ORAL OR HYPODERMIC DOSE OF PILOCARPINE、NOW RARELY USED、IS 5 TO 10 MG. DEVICE FOR ACHIEVING SUSTAINED RELEASE OF PILOCARPINE INTO CUL-DE-SAC OF EYE IS ALSO AVAIL (OCUSERT). |
登记用途：Uses: MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 75.1、For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjö、grens syndrome.、Methods of Manufacturing: TOTAL ALKALOIDS ARE EXTRACTED FROM...SUITABLE PILOCARPUS SPECIES、WITH ALC CONTAINING SMALL AMT OF HYDROCHLORIC ACID. SOLVENT DISTD OFF...RESINS ARE ALL DEPOSITED. ...FILTERED...EVAPORATED TO SMALL BULK. AMMONIA IS ADDED IN EXCESS & FREE ALKALOIDS EXTRACTED WITH CHLOROFORM.、PREOBRASHENSKI ET AL、BER 66、1187 (1933)、SAMOKH ALOV、MED PROM SSSR 11、NO 2、10 (1957)...、Formulations、Preparations: ADSORBOCARPINE (BURTON、PARSONS)...ALMOCARPINE (AYERST)...ISOPTO CARPINE (ALCON)...MI-PILO (BARNES-HIND)...MISTURA P (LEDERLE)...PILOCAR (SMP)...PILOCEL (SOFTCON PRODUCTS)...PILOMIOTON (SMP)...、HCL、PV CARPINE LIQUIFILM (ALLERGAN)...PILOFRIN LIQUIFILM (ALLERGAN)...、NITRATE、OCUSERT PILO-20、PILO-40、(ALZA)、General Manufacturing Information: 2(3H)-Furanone、3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-、(3S、4R)-: ACTIVE、PILOCARPINE、HAS CIS CONFIGURATION、ISOPILOCARPINE IS TRANS: ZAV'VANOL、DOKLADY ADAD NAUK SSSR 82、257 (1952). ABSOLUTE CONFIGURATION: HILL、BARCZA、TETRAHEDRON 22、2889 (1966).、INCOMPATIBILITIES: SILVER NITRATE、MERCURY BICHLORIDE、IODIDES、GOLD SALTS、TANNIN、CALOMEL、POTASSIUM PERMANGANATE、ALKALIES.、OCUSERT、...IS ELLIPTICALLY SHAPED UNIT...OF PILOCARPINE-CONTAINING RESERVOIR SURROUNDED BY PERMEABLE MEMBRANE. FOLLOWING PLACEMENT BY PT、DIFFERENT FORMS OF UNIT ARE DESIGNED TO RELEASE PILOCARPINE @ RATE OF EITHER 20 OR 40 UG、HR FOR 1 WK. INTRAOCULAR PRESSURE IS REDUCED CONTINUOUSLY...WITH...LESS TOTAL DRUG...、PILOCARPINE HYDROCHLORIDE & PILOCARPINE NITRATE ARE OFFICIAL IN USP BOTH AS SALTS & AS OPHTHALMIC SOLN. AVG ORAL OR HYPODERMIC DOSE OF PILOCARPINE、NOW RARELY USED、IS 5 TO 10 MG. DEVICE FOR ACHIEVING SUSTAINED RELEASE OF PILOCARPINE INTO CUL-DE-SAC OF EYE IS ALSO AVAIL (OCUSERT).。
毛果芸香碱 是一种化工化合物，登记 CAS 号为 92-13-7，分子式 C11H16N2O2（分子量 208.26）。
登记 CAS 号：92-13-7
其分子式 C11H16N2O2 由 11 个碳、16 个氢、2 个氮、2 个氧 组成。
别名/同义词：毛果芸香碱 · pilocarpine
毛果芸香碱 的 CAS 登记号为 92-13-7。
分子式 C11H16N2O2，分子量 208.26。
别名/同义词：毛果芸香碱、pilocarpine。
登记用途：Uses: MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 75.1、For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjö、grens syndrome.、Methods of Manufacturing: TOTAL ALKALOIDS ARE EXTRACTED FROM...SUITABLE PILOCARPUS SPECIES、WITH ALC CONTAINING SMALL AMT OF HYDROCHLORIC ACID. SOLVENT DISTD OFF...RESINS ARE ALL DEPOSITED. ...FILTERED...EVAPORATED TO SMALL BULK. AMMONIA IS ADDED IN EXCESS & FREE ALKALOIDS EXTRACTED WITH CHLOROFORM.、PREOBRASHENSKI ET AL、BER 66、1187 (1933)、SAMOKH ALOV、MED PROM SSSR 11、NO 2、10 (1957)...、Formulations、Preparations: ADSORBOCARPINE (BURTON、PARSONS)...ALMOCARPINE (AYERST)...ISOPTO CARPINE (ALCON)...MI-PILO (BARNES-HIND)...MISTURA P (LEDERLE)...PILOCAR (SMP)...PILOCEL (SOFTCON PRODUCTS)...PILOMIOTON (SMP)...、HCL、PV CARPINE LIQUIFILM (ALLERGAN)...PILOFRIN LIQUIFILM (ALLERGAN)...、NITRATE、OCUSERT PILO-20、PILO-40、(ALZA)、General Manufacturing Information: 2(3H)-Furanone、3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-、(3S、4R)-: ACTIVE、PILOCARPINE、HAS CIS CONFIGURATION、ISOPILOCARPINE IS TRANS: ZAV'VANOL、DOKLADY ADAD NAUK SSSR 82、257 (1952). ABSOLUTE CONFIGURATION: HILL、BARCZA、TETRAHEDRON 22、2889 (1966).、INCOMPATIBILITIES: SILVER NITRATE、MERCURY BICHLORIDE、IODIDES、GOLD SALTS、TANNIN、CALOMEL、POTASSIUM PERMANGANATE、ALKALIES.、OCUSERT、...IS ELLIPTICALLY SHAPED UNIT...OF PILOCARPINE-CONTAINING RESERVOIR SURROUNDED BY PERMEABLE MEMBRANE. FOLLOWING PLACEMENT BY PT、DIFFERENT FORMS OF UNIT ARE DESIGNED TO RELEASE PILOCARPINE @ RATE OF EITHER 20 OR 40 UG、HR FOR 1 WK. INTRAOCULAR PRESSURE IS REDUCED CONTINUOUSLY...WITH...LESS TOTAL DRUG...、PILOCARPINE HYDROCHLORIDE & PILOCARPINE NITRATE ARE OFFICIAL IN USP BOTH AS SALTS & AS OPHTHALMIC SOLN. AVG ORAL OR HYPODERMIC DOSE OF PILOCARPINE、NOW RARELY USED、IS 5 TO 10 MG. DEVICE FOR ACHIEVING SUSTAINED RELEASE OF PILOCARPINE INTO CUL-DE-SAC OF EYE IS ALSO AVAIL (OCUSERT).。
毛果芸香碱（CAS 92-13-7）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 92-13-7 |
|---|---|
| PubChem CID | 5910 |
| Molecular formula | C11H16N2O2 |
| IUPAC name | (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one |
| UNII (FDA) | 01MI4Q9DI3 |
| Molecular Weight | 208.26 |
|---|---|
| XLogP3 | 1.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 208.121177757 |
| Monoisotopic Mass | 208.121177757 |
| Topological Polar Surface Area | 44.1 |
| Heavy Atom Count | 15 |
| Melting Point | 195-205 |
|---|---|
| Melting Point | 34 °C |
| Solubility | 2.07e+00 g/L |
| LogP | -3.03 |
| LogP | 1.1 |
| LogP | 0.66 |
| Dissociation Constants | PK1= 7.15; PK2= 12.57 @ 20 °C |
pilocarpine; 92-13-7; Pilokarpin; Pilocarpol; Syncarpine; Ocusert pilo; Pilocarpin; Spersacarpine; Ocusert pilo-20; Ocusert Pilo-40; Ocusert P 20; ocucarpine; Pilocarpine muriate; Pilovisc; Pilocarpinum; DTXSID1021162
| Reported hazard statements | H300, H330, H310, H370 |
|---|
H300: Fatal if swallowed [Danger Acute toxicity, oral]
H330: Fatal if inhaled [Danger Acute toxicity, inhalation]
pilocarpine · CAS 92-13-7 · C11H16N2O2. UNII 01MI4Q9DI3. Melting Point: 195-205; Melting Point: 34 °C; Solubility: 2.07e+00 g/L.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: pilocarpine