酚妥拉明（CAS 50-60-2）：分子式 C17H19N3O、分子量 281.35。
| CAS号 | 50-60-2 |
|---|---|
| 分子式 | C17H19N3O |
| 分子量 | 281.35 |
| 熔点 | 181 |
| LogP | 3.3 |
| 应用领域 | Uses: Treatment of hypertension and hypertensive emergencies、pheochromocytoma、vasospasm of Raynaud disease and frostbite、clonidine withdrawal syndrome、impotence、and peripheral vascular disease、To relieve pseudo-obstruction of the bowel in patients with pheochromocytoma、to prevent dermal necrosis after inadvertent extravasation of an alpha-receptor antagonist、for treatment of hypertensive crisis that follow the abrupt withdrawal of clonidine or that may result from the ingestion of tyramine-containing food during the use of nonselective MAO inhibitors.、THERAPEUTIC CATEGORY: Antihypertensive in treatment of pheochromocytoma、diagnostic aid (pheochromocytoma). In treatment of male erectile dysfunction.、MEDICATION、Use Classification: Pharmaceuticals、Methods of Manufacturing: m-(p-Toluidino)phenol is refluxed with 2-chloromethylimidazoline hydrochloride and the resulting phentolamine base treated with an equimolar protion of methanesulfonic acid.、Phentolamine mesylate、Formulations、Preparations: For injection、powder、lyophilized、for suspension: vials each containing 5 mg of phentolamine mesylate for injection、USP、and 25 mg of mannitol、inlyophilized form、Regitine (Novartis).、For injection、solution for submucosal use: 0.4 mg、1.7 mL solution per cartridge、OraVerse (Novalar).、Parenteral: For injection: 5 mg Phentolamine Mesylate for Injection (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name).、General Manufacturing Information: No longer widely used because of its side effects、which include arrhythmia and tachycardia、. |
登记用途：Uses: Treatment of hypertension and hypertensive emergencies、pheochromocytoma、vasospasm of Raynaud disease and frostbite、clonidine withdrawal syndrome、impotence、and peripheral vascular disease、To relieve pseudo-obstruction of the bowel in patients with pheochromocytoma、to prevent dermal necrosis after inadvertent extravasation of an alpha-receptor antagonist、for treatment of hypertensive crisis that follow the abrupt withdrawal of clonidine or that may result from the ingestion of tyramine-containing food during the use of nonselective MAO inhibitors.、THERAPEUTIC CATEGORY: Antihypertensive in treatment of pheochromocytoma、diagnostic aid (pheochromocytoma). In treatment of male erectile dysfunction.、MEDICATION、Use Classification: Pharmaceuticals、Methods of Manufacturing: m-(p-Toluidino)phenol is refluxed with 2-chloromethylimidazoline hydrochloride and the resulting phentolamine base treated with an equimolar protion of methanesulfonic acid.、Phentolamine mesylate、Formulations、Preparations: For injection、powder、lyophilized、for suspension: vials each containing 5 mg of phentolamine mesylate for injection、USP、and 25 mg of mannitol、inlyophilized form、Regitine (Novartis).、For injection、solution for submucosal use: 0.4 mg、1.7 mL solution per cartridge、OraVerse (Novalar).、Parenteral: For injection: 5 mg Phentolamine Mesylate for Injection (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name).、General Manufacturing Information: No longer widely used because of its side effects、which include arrhythmia and tachycardia、.。
酚妥拉明 是一种化工化合物，登记 CAS 号为 50-60-2，分子式 C17H19N3O（分子量 281.35）。
登记 CAS 号：50-60-2
其分子式 C17H19N3O 由 17 个碳、19 个氢、3 个氮、1 个氧 组成。
别名/同义词：酚妥拉明 · phentolamine
酚妥拉明 的 CAS 登记号为 50-60-2。
分子式 C17H19N3O，分子量 281.35。
别名/同义词：酚妥拉明、phentolamine。
登记用途：Uses: Treatment of hypertension and hypertensive emergencies、pheochromocytoma、vasospasm of Raynaud disease and frostbite、clonidine withdrawal syndrome、impotence、and peripheral vascular disease、To relieve pseudo-obstruction of the bowel in patients with pheochromocytoma、to prevent dermal necrosis after inadvertent extravasation of an alpha-receptor antagonist、for treatment of hypertensive crisis that follow the abrupt withdrawal of clonidine or that may result from the ingestion of tyramine-containing food during the use of nonselective MAO inhibitors.、THERAPEUTIC CATEGORY: Antihypertensive in treatment of pheochromocytoma、diagnostic aid (pheochromocytoma). In treatment of male erectile dysfunction.、MEDICATION、Use Classification: Pharmaceuticals、Methods of Manufacturing: m-(p-Toluidino)phenol is refluxed with 2-chloromethylimidazoline hydrochloride and the resulting phentolamine base treated with an equimolar protion of methanesulfonic acid.、Phentolamine mesylate、Formulations、Preparations: For injection、powder、lyophilized、for suspension: vials each containing 5 mg of phentolamine mesylate for injection、USP、and 25 mg of mannitol、inlyophilized form、Regitine (Novartis).、For injection、solution for submucosal use: 0.4 mg、1.7 mL solution per cartridge、OraVerse (Novalar).、Parenteral: For injection: 5 mg Phentolamine Mesylate for Injection (Available from one or more manufacturer、distributor、and、or repackager by generic (nonproprietary) name).、General Manufacturing Information: No longer widely used because of its side effects、which include arrhythmia and tachycardia、.。
酚妥拉明（CAS 50-60-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 50-60-2 |
|---|---|
| PubChem CID | 5775 |
| Molecular formula | C17H19N3O |
| IUPAC name | 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol |
| UNII (FDA) | Z468598HBV |
| Molecular Weight | 281.35 |
|---|---|
| XLogP3 | 2.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 281.152812238 |
| Monoisotopic Mass | 281.152812238 |
| Topological Polar Surface Area | 47.9 |
| Heavy Atom Count | 21 |
| Melting Point | 181 |
|---|---|
| Melting Point | 175 °C |
| Melting Point | 174.5 °C |
| Solubility | 2.72e-01 g/L |
| LogP | 3.3 |
phentolamine; 50-60-2; Regitin; Dibasin; Fentolamin; Fentolamina; Rogitine; Phentolaminum; C 7337 Ciba; Phentolamin; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; C 7337; DTXSID4023462; 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline; 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 2-((N-(m-Hydroxyphenyl)-p-toluidino)methyl)-2-imidazoline
| Reported hazard statements | H302 (100%), H315 (100%), H319 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
phentolamine · CAS 50-60-2 · C17H19N3O. UNII Z468598HBV. Melting Point: 181; Melting Point: 175 °C; Melting Point: 174.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: phentolamine